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Rbm5 Gene Detail
Summary
  • Symbol
    Rbm5
  • Name
    RNA binding motif protein 5
  • Synonyms
    D030069N10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933204
    NCBI Gene: 83486
  • Gene Overview
    MyGene.info: RBM5
Location & Maps
more
  • Sequence Map
    Chr9:107740371-107770996 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30626 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RBM5, RNA binding motif protein 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RBM5, RNA binding motif protein 5
    Orthology source: HomoloGene
  • Synonyms
    G15, H37, LUCA15, RMB5
  • Links
    NCBI Gene ID: 10181
    neXtProt AC: NX_P52756

  • Chr Location
    3p21.3; chr3:50088908-50118964 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 21177
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: RBM5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    47
  • Chemically induced (ENU)
    1
  • Gene trapped
    46
  • Incidental Mutations
Mice homozygous for an ENU-induced allele exhibit male infertility with azoospermia, male germ cell apoptosis, round spermatid arrest and spermatid differentiation arrest.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043551 VEGA Gene Model | MGI Sequence Detail 30626 C57BL/6J ±  kb
transcript OTTMUST00000114281 VEGA | MGI Sequence Detail 3205 Not Applicable  
polypeptide OTTMUSP00000063790 VEGA | MGI Sequence Detail 815 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    99 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 268
    cDNA 267
    Primer pair 1

    Microarray probesets 10
Other
Accession IDs
less
MGI:2443530
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:66052 Lerman MI, et al., The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium [In Process Citation]. Cancer Res. 2000 Nov 1;60(21):6116-33
  • Latest
    J:223049 O'Bryan MK, et al., RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility. PLoS Genet. 2013;9(7):e1003628

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory