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Rad54l2 Gene Detail
Summary
  • Symbol
    Rad54l2
  • Name
    RAD54 like 2 (S. cerevisiae)
  • Synonyms
    Arip4, G630026H09Rik, Srisnf2l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933196
    NCBI Gene: 81000
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:106688082-106789194 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 57.98 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    575 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933196
protein coding gene Chr9:106688080-106789213 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035243
protein coding gene Chr9:108507135-108620092 (-)
A/J MGP_AJ_G0035222
protein coding gene Chr9:104573401-104680480 (-)
AKR/J MGP_AKRJ_G0035154
protein coding gene Chr9:107181158-107286343 (-)
BALB/cJ MGP_BALBcJ_G0035216
protein coding gene Chr9:104261650-104368971 (-)
C3H/HeJ MGP_C3HHeJ_G0034926
protein coding gene Chr9:107597980-107703718 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035736
protein coding gene Chr9:111496060-111607789 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032634
protein coding gene Chr9:102060165-102167838 (-)
CAST/EiJ MGP_CASTEiJ_G0034237
protein coding gene Chr9:107517889-107624544 (-)
CBA/J MGP_CBAJ_G0034894
protein coding gene Chr9:115451753-115580017 (-)
DBA/2J MGP_DBA2J_G0035055
protein coding gene Chr9:104038556-104140795 (-)
FVB/NJ MGP_FVBNJ_G0035003
protein coding gene Chr9:102818085-102922925 (-)
LP/J MGP_LPJ_G0035131
protein coding gene Chr9:108718983-108832487 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035042
protein coding gene Chr9:117021711-117133240 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035757
protein coding gene Chr9:107443901-107553694 (-)
PWK/PhJ MGP_PWKPhJ_G0033944
protein coding gene Chr9:104347771-104454127 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033779
protein coding gene Chr9:107520641-107629810 (-)
WSB/EiJ MGP_WSBEiJ_G0034358
protein coding gene Chr9:107347673-107456380 (-)



Homology
more
  • Human Ortholog
    RAD54L2, RAD54 like 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAD54L2, RAD54 like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARIP4, HSPC325, SRISNF2L
  • Links
    NCBI Gene ID: 23132
    neXtProt AC: NX_Q9Y4B4
    UniProt: Q9Y4B4

  • Chr Location
    3p21.2; chr3:51538683-51668660 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null embryos show delayed growth, reduced cell proliferation, increased apoptosis and die by E11.5. At E9.5-E10.5, most major organs are smaller and the neural tube is shrunk in some cases. Mutant MEFs cease to grow after 2-3 passages showing increased apoptosis and reduced DNA synthesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040661 Ensembl Gene Model | MGI Sequence Detail 101113 C57BL/6J ±  kb
    transcript ENSMUST00000046502 Ensembl | MGI Sequence Detail 9305 Not Applicable  
    polypeptide ENSMUSP00000045454 Ensembl | MGI Sequence Detail 1467 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • EC
    • InterPro Domains
      IPR001650 Helicase, C-terminal
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR000330 SNF2-related, N-terminal domain
    Molecular
    Reagents
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    • All nucleic 65
      cDNA 64
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2442051
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 3
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory