About   Help   FAQ
Nxf2
Gene Detail
Symbol

Name
ID
Nxf2
nuclear RNA export factor 2
MGI:1933192
Synonyms
4930455N06Rik, Nxf-b
Feature Type
protein coding gene
Genetic Map
Chromosome X
56.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
ChrX:134944526-134964754 bp, - strand
From VEGA annotation of GRCm38

  20229 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88604  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 3 dog

HCOP human homology predictions: NXF2, NXF2B
Gene Tree: Nxf2

Human
homologs
NXF2, nuclear RNA export factor 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 56001
neXtProt AC: NX_Q9GZY0

Human Synonyms: CT39, TAPL-2, TCP11X2

Human Chr (Location): Xq22.1; chrX:102247100-102326720 (+)  GRCh38.p2

  1 More Homolog(s):
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Nxf2 (2)
Incidental mutations (data from APF )
 
Male mice heterogyzous for the null allele exhibit reduced fertility associated with abnormal meiosis or reduced spermatogonia proliferation depending on strain background.
 
Interactions
Nxf2 interacts with 79 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process poly(A)+ mRNA export from nucleus, RNA export from nucleus
Component cell, intracellular, ...
Function mRNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (57)    Tissues (46)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 31
Western blot 11
RT-PCR 15
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(8) Primer pair(4)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000018751 (Evidence)
Ensembl Gene Model ENSMUSG00000009941 (Evidence)
Entrez Gene 83454 (Evidence)
UniGene 103155
DFCI TC1588240, TC1593388
DoTS DT.55268933, DT.91446642, DT.91446643, DT.91446645
NIA Mouse Gene Index U039708
Consensus CDS Project CCDS41125.1, CCDS72433.1, CCDS81173.1
International Mouse Phenotyping Consortium Status Nxf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018751 VEGA Gene Model | MGI Sequence Detail 20229 C57BL/6J ±  kb
transcript OTTMUST00000045097 VEGA | MGI Sequence Detail 2393 Not Applicable 
polypeptide OTTMUSP00000020272 VEGA | MGI Sequence Detail 691 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR030217 Nuclear RNA export factor
InterPro IPR015245 Nuclear RNA export factor Tap, RNA-binding domain
InterPro IPR002075 Nuclear transport factor 2
InterPro IPR018222 Nuclear transport factor 2, eukaryote
InterPro IPR012677 Nucleotide-binding alpha-beta plait domain
InterPro IPR005637 TAP C-terminal (TAP-C) domain
InterPro IPR009060 UBA-like
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:200621 Vanmarsenille L, et al., Generation and characterization of an Nxf7 knockout mouse to study NXF5 deficiency in a patient with intellectual disability. PLoS One. 2013;8(5):e64144
All references(35)
Other
accession IDs
MGI:1922121

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory