About   Help   FAQ
Nxf2 Gene Detail
Summary
  • Symbol
    Nxf2
  • Name
    nuclear RNA export factor 2
  • Synonyms
    4930455N06Rik, Nxf-b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933192
    NCBI Gene: 83454
Location & Maps
more
  • Sequence Map
    ChrX:134944526-134964754 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20229 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 56.31 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    NXF2, nuclear RNA export factor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NXF2, nuclear RNA export factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT39, TAPL-2, TCP11X2
  • Links
    NCBI Gene ID: 56001
    neXtProt AC: NX_Q9GZY0

  • Chr Location
    Xq22.1; chrX:102247100-102326720 (+)  GRCh38.p2

  • Human Ortholog
    NXF2B, nuclear RNA export factor 2B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA353J17.1, TCP11X1
  • Links
    NCBI Gene ID: 728343
    neXtProt AC: NX_Q9GZY0

  • Chr Location
    Xq22.1; chrX:102360395-102440008 (-)  GRCh38.p2

  • Human Ortholog
    NXF5, nuclear RNA export factor 5
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 55998
    neXtProt AC: NX_Q9H1B4

  • Chr Location
    Xq22; chrX:101832112-101857577 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Targeted
    6
  • Genomic Mutations
    2 involving Nxf2
  • Incidental Mutations
    APF
Male mice heterogyzous for the null allele exhibit reduced fertility associated with abnormal meiosis or reduced spermatogonia proliferation depending on strain background.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018751 VEGA Gene Model | MGI Sequence Detail 20229 C57BL/6J ±  kb
transcript OTTMUST00000045097 VEGA | MGI Sequence Detail 2393 Not Applicable  
polypeptide OTTMUSP00000020272 VEGA | MGI Sequence Detail 691 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    67 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 8
    Primer pair 4

    Microarray probesets 2
Other
Accession IDs
less
MGI:1922121
References
more
  • Summaries
    All 32
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:200621 Vanmarsenille L, et al., Generation and characterization of an Nxf7 knockout mouse to study NXF5 deficiency in a patient with intellectual disability. PLoS One. 2013;8(5):e64144

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory