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Nxf2 Gene Detail
Summary
  • Symbol
    Nxf2
  • Name
    nuclear RNA export factor 2
  • Synonyms
    4930455N06Rik, Nxf-b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933192
    NCBI Gene: 83454
  • Alliance
Location & Maps
more
  • Sequence Map
    ChrX:134944526-134964754 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20229 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 56.31 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    NXF2, nuclear RNA export factor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NXF2, nuclear RNA export factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT39, TAPL-2, TCP11X2
  • Links
    NCBI Gene ID: 56001
    neXtProt AC: NX_Q9GZY0
    UniProt: Q5H9J9, Q9GZY0

  • Chr Location
    Xq22.1; chrX:102247100-102326720 (+)  GRCh38.p7

  • Human Ortholog
    NXF2B, nuclear RNA export factor 2B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA353J17.1
  • Links
    NCBI Gene ID: 728343
    neXtProt AC: NX_Q9GZY0
    UniProt: Q9GZY0

  • Chr Location
    Xq22.1; chrX:102360395-102440008 (-)  GRCh38.p7

  • Human Ortholog
    NXF5, nuclear RNA export factor 5
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 55998
    neXtProt AC: NX_Q9H1B4
    UniProt: Q9H1B4

  • Chr Location
    Xq22.1; chrX:101832112-101857577 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice heterogyzous for the null allele exhibit reduced fertility associated with abnormal meiosis or reduced spermatogonia proliferation depending on strain background.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000018751 VEGA Gene Model | MGI Sequence Detail 20229 C57BL/6J ±  kb
    transcript OTTMUST00000045097 VEGA | MGI Sequence Detail 2393 Not Applicable  
    polypeptide OTTMUSP00000020272 VEGA | MGI Sequence Detail 691 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      67 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR032710 NTF2-like domain superfamily
      IPR030217 Nuclear RNA export factor
      IPR015245 Nuclear RNA export factor Tap, RNA-binding domain
      IPR002075 Nuclear transport factor 2
      IPR018222 Nuclear transport factor 2, eukaryote
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR005637 TAP C-terminal (TAP-C) domain
      IPR009060 UBA-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 8
      Primer pair 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1922121
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:210663 Zhou J, et al., Respiratory failure, cleft palate and epilepsy in the mouse model of human Xq22.1 deletion syndrome. Hum Mol Genet. 2014 Jul 15;23(14):3823-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory