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Nxf2
Gene Detail
 Symbol
Name
ID
Nxf2
nuclear RNA export factor 2
MGI:1933192
Synonyms 4930455N06Rik, Nxf-b
Feature Type protein coding gene
Genetic Map
Chromosome X
56.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
ChrX:134944526-134964754 bp, - strand
From VEGA annotation of GRCm38

  20229 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88604  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 3 dog

Gene Tree: Nxf2

Human
homologs
Human Homolog NXF2, nuclear RNA export factor 2
NCBI Gene ID 56001
neXtProt AC  NX_Q9GZY0
Human Synonyms  CT39, TAPL-2, TCP11X2
Human Chr (Location)  Xq22.1; chrX:102247100-102326720 (+)  GRCh38
Human Homolog NXF2B, nuclear RNA export factor 2B
NCBI Gene ID 728343
neXtProt AC  NX_Q9GZY0
Human Synonyms  bA353J17.1, TCP11X1
Human Chr (Location)  Xq22.1; chrX:102360395-102440008 (-)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Male mice heterogyzous for the null allele exhibit reduced fertility associated with abnormal meiosis or reduced spermatogonia proliferation depending on strain background.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process poly(A)+ mRNA export from nucleus, RNA export from nucleus
Component cell, intracellular, ...
Function mRNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (33)    Tissues (23)    Images (4)
Theiler Stages: 21, 26, 28
Assay TypeResults
RNA in situ 20
Western blot 11
RT-PCR 2
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(9) cDNA(7) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000018751 (Evidence)
Ensembl Gene ModelENSMUSG00000009941 (Evidence)
Entrez Gene83454 (Evidence)
UniGene103155
DFCITC1588240, TC1593388
DoTSDT.55268933, DT.91446642, DT.91446643, DT.91446645
NIA Mouse Gene IndexU039708
Consensus CDS ProjectCCDS41125.1, CCDS72433.1
International Mouse Knockout Project StatusNxf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018751 VEGA Gene Model | MGI Sequence Detail 20229 C57BL/6J ±  kb
transcript OTTMUST00000045097 VEGA | MGI Sequence Detail 2393 Not Applicable 
polypeptide OTTMUSP00000020272 VEGA | MGI Sequence Detail 691 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(8) UniProt(5)
Polymorphisms SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR015245 Nuclear RNA export factor Tap, RNA-binding domain
InterPro IPR002075 Nuclear transport factor 2
InterPro IPR018222 Nuclear transport factor 2, Eukaryote
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR005637 TAP C-terminal (TAP-C) domain
InterPro IPR009060 UBA-like
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:199138 Zhou J, et al., A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice. Biol Reprod. 2013 Jun;88(6):159
All references(35)
Other
accession IDs
MGI:1922121

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory