Nop58 MGI Mouse Gene Detail - MGI:1933184

Symbol

Nop58
Name

NOP58 ribonucleoprotein
Synonyms

MSSP, Nol5, SIK similar protein

Feature Type

protein coding gene
IDs

MGI:1933184
NCBI Gene: 55989
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:59724165-59751352 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 30.38 cM, cytoband C2
Mapping Data

2 experiments

SNPs within 2kb

616 from dbSNP Build 142
Strain Annotations

39

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933184	protein coding gene	Chr1:59724130-59758203 (+)
129S1/SvImJ	ENSMUSGG00200054884	protein coding gene	Chr1:57223253-57230927 (+)
129S1/SvImJ	ENSMUSG00200018236	protein coding gene	Chr1:57234169-57234268 (+)
129S1/SvImJ	ENSMUSGG00200054663	protein coding gene	Chr1:57236607-57244958 (+)
A/J	ENSMUSGG00195054934	protein coding gene	Chr1:56762490-56770164 (+)
A/J	ENSMUSG00195028164	protein coding gene	Chr1:56773410-56773509 (+)
A/J	ENSMUSGG00195054931	protein coding gene	Chr1:56775848-56784199 (+)
AKR/J	ENSMUSG00220036368	protein coding gene	Chr1:56857936-56858035 (+)
AKR/J	ENSMUSGG00220054654	protein coding gene	Chr1:56860393-56868746 (+)
AKR/J	ENSMUSGG00220054833	protein coding gene	Chr1:56847021-56854692 (+)
BALB/cJ	ENSMUSGG00180055355	protein coding gene	Chr1:56997054-57004726 (+)
BALB/cJ	ENSMUSGG00180055567	protein coding gene	Chr1:57010421-57018774 (+)
BALB/cJ	ENSMUSG00180013146	protein coding gene	Chr1:57007964-57008063 (+)
C3H/HeJ	ENSMUSGG00175054575	protein coding gene	Chr1:57139902-57147576 (+)
C3H/HeJ	ENSMUSG00175000822	protein coding gene	Chr1:57150820-57150919 (+)
C3H/HeJ	ENSMUSGG00175054576	protein coding gene	Chr1:57153258-57161609 (+)
C57BL/6NJ	ENSMUSGG00215055646	protein coding gene	Chr1:57085132-57093483 (+)
C57BL/6NJ	ENSMUSG00215028029	protein coding gene	Chr1:57082694-57082793 (+)
C57BL/6NJ	ENSMUSGG00215055709	protein coding gene	Chr1:57071774-57079448 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014181	protein coding gene	Chr1:53801281-53828648 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSGG00210054925	protein coding gene	Chr1:56838276-56846627 (+)
CBA/J	ENSMUSG00210036219	protein coding gene	Chr1:56835838-56835937 (+)
CBA/J	ENSMUSGG00210054714	protein coding gene	Chr1:56824918-56832592 (+)
DBA/2J	ENSMUSG00185037593	protein coding gene	Chr1:57955532-57955631 (+)
DBA/2J	ENSMUSGG00185057339	protein coding gene	Chr1:57944612-57952286 (+)
DBA/2J	ENSMUSGG00185057605	protein coding gene	Chr1:57957970-57966321 (+)
FVB/NJ	ENSMUSGG00205054277	protein coding gene	Chr1:56785727-56793401 (+)
FVB/NJ	ENSMUSGG00205054276	protein coding gene	Chr1:56799083-56807434 (+)
FVB/NJ	ENSMUSG00205017995	protein coding gene	Chr1:56796645-56796744 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSGG00230055841	protein coding gene	Chr1:57945154-57952828 (+)
LP/J	ENSMUSG00230028950	protein coding gene	Chr1:57956070-57956169 (+)
LP/J	ENSMUSGG00230055588	protein coding gene	Chr1:57958508-57966859 (+)
NOD/ShiLtJ	ENSMUSG00190036392	protein coding gene	Chr1:56989018-56989117 (+)
NOD/ShiLtJ	ENSMUSGG00190054931	protein coding gene	Chr1:56991475-56999828 (+)
NOD/ShiLtJ	ENSMUSGG00190054607	protein coding gene	Chr1:56978109-56985780 (+)
NZO/HlLtJ	ENSMUSG00225007699	protein coding gene	Chr1:61152615-61160631 (+)
NZO/HlLtJ	ENSMUSGG00225055499	protein coding gene	Chr1:61163666-61163765 (+)
NZO/HlLtJ	ENSMUSGG00225055498	protein coding gene	Chr1:61166315-61174879 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010023347	protein coding gene	Chr1:58357123-58391608 (+)
WSB/EiJ	no annotation

Human Ortholog

NOP58, NOP58 ribonucleoprotein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NOP58, NOP58 ribonucleoprotein
Synonyms

HSPC120, NOP5, NOP5/NOP58
Links

HGNC:29926

NCBI Gene ID: 51602

UniProt: Q9Y2X3
Chr Location

2q33.1; chr2:202265725-202303666 (+) GRCh38

MGI Vertebrate Homology

Nop58 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NOP58
Gene Tree

Nop58

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

201
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

194
Radiation induced

1
Genomic Mutations

2 involving Nop58
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

96 strains or lines available

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All GO Annotations

40
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

602
Tissues

5
cDNA Data

129
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nop58

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All Sequences

114
RefSeq

26
UniProt

10
CCDS

CCDS35587.1

Ensembl

ENSMUSG00000026020 (Evidence)
NCBI Gene

55989

			Length	Strain/Species	Flank
genomic	55989	NCBI Gene Model \| MGI Sequence Detail	27188	C57BL/6J	± kb
transcript	NM_001420739	RefSeq \| MGI Sequence Detail	2911	C57BL/6
polypeptide	Q6DFW4	UniProt \| EBI \| MGI Sequence Detail	536	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000011325 nucleolar protein 58

(term hierarchy)
InterPro Domains

IPR042239 Nop, C-terminal domain

IPR002687 Nop domain

IPR036070 Nop domain superfamily

IPR012976 NOSIC

IPR012974 Nucleolar protein 58/56, N-terminal

IPR045056 Nucleolar protein Nop56/Nop58
GlyGen

Q6DFW4 1 site, 1 O-linked glycan (1 site)

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All nucleic 130

cDNA 129

Primer pair 1

Microarray probesets 3

Summaries

All 49

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 15
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:380828 Al Adhami H, et al., Systematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells. Nucleic Acids Res. 2023 Apr 24;51(7):3130-3149

TSS for Nop58:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6885	Chr1:59724108-59724182 (+)	-20 bp
Tssr6886	Chr1:59728703-59728707 (+)	4,540 bp
Tssr6887	Chr1:59737219-59737234 (+)	13,062 bp
Tssr6888	Chr1:59744801-59744814 (+)	20,643 bp
Tssr6889	Chr1:59744818-59744852 (+)	20,670 bp
Tssr6890	Chr1:59746158-59746197 (+)	22,013 bp
Tssr6891	Chr1:59748159-59748199 (+)	24,014 bp
Tssr6892	Chr1:59749676-59749708 (+)	25,527 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24