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Srcin1 Gene Detail
Summary
  • Symbol
    Srcin1
  • Name
    SRC kinase signaling inhibitor 1
  • Synonyms
    mKIAA1684, P140, p140Cap
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933179
    NCBI Gene: 56013
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:97509340-97575126 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.00 cM, cytoband D
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    229 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933179
protein coding gene Chr11:97509340-97576186 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019033
protein coding gene Chr11:99942870-100018927 (-)
A/J MGP_AJ_G0019001
protein coding gene Chr11:95826685-95892738 (-)
AKR/J MGP_AKRJ_G0018971
protein coding gene Chr11:98806339-98872392 (-)
BALB/cJ MGP_BALBcJ_G0018974
protein coding gene Chr11:96315144-96382369 (-)
C3H/HeJ MGP_C3HHeJ_G0018788
protein coding gene Chr11:98921922-98988535 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019426
protein coding gene Chr11:103039083-103111204 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017057
protein coding gene Chr11:93286531-93353549 (-)
CAST/EiJ MGP_CASTEiJ_G0018341
protein coding gene Chr11:99782581-99851777 (-)
CBA/J MGP_CBAJ_G0018759
protein coding gene Chr11:107281100-107358458 (-)
DBA/2J MGP_DBA2J_G0018867
protein coding gene Chr11:95381991-95448440 (-)
FVB/NJ MGP_FVBNJ_G0018856
protein coding gene Chr11:94872267-94941455 (-)
LP/J MGP_LPJ_G0018937
protein coding gene Chr11:100451931-100528659 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018883
protein coding gene Chr11:107143430-107213879 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019466
protein coding gene Chr11:99102444-99171413 (-)
PWK/PhJ MGP_PWKPhJ_G0018113
protein coding gene Chr11:96364826-96431773 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017903
protein coding gene Chr11:98811570-98883772 (-)
WSB/EiJ MGP_WSBEiJ_G0018391
protein coding gene Chr11:99006357-99074670 (-)



Homology
more
  • Human Ortholog
    SRCIN1, SRC kinase signaling inhibitor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SRCIN1, SRC kinase signaling inhibitor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    P140, SNIP
  • Links
    NCBI Gene ID: 80725
    neXtProt AC: NX_Q9C0H9
    UniProt: Q9C0H9

  • Chr Location
    17q12; chr17:38530015-38607166 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10324
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SRCIN1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display abnormalities in object recognition memory and motor learning, dendritic spine disorganization, impaired synaptic plasticity, and reduced long term potentiation and long term depression.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56013 NCBI Gene Model | MGI Sequence Detail 65787 C57BL/6J ±  kb
transcript NM_018873 RefSeq | MGI Sequence Detail 6965 C57BL/6  
polypeptide Q9QWI6 UniProt | EBI | MGI Sequence Detail 1250 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR022782 Actin interacting protein 3-like, C-terminal
    IPR026727 SRC kinase signalling inhibitor 1
Molecular
Reagents
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  • All nucleic 18
    cDNA 18

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:253234 Li MY, et al., A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex. Neuron. 2017 Jun 21;94(6):1155-1172.e8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory