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Srcin1 Gene Detail
Summary
  • Symbol
    Srcin1
  • Name
    SRC kinase signaling inhibitor 1
  • Synonyms
    mKIAA1684, P140, p140Cap
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933179
    NCBI Gene: 56013
Location & Maps
more
  • Sequence Map
    Chr11:97509340-97576186 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      66847 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.00 cM, cytoband D
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SRCIN1, SRC kinase signaling inhibitor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SRCIN1, SRC kinase signaling inhibitor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    P140, SNIP
  • Links
    NCBI Gene ID: 80725
    neXtProt AC: NX_Q9C0H9

  • Chr Location
    17q12; chr17:38530024-38605930 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Gene trapped
    13
  • Targeted
    4
  • Genomic Mutations
    1 involving Srcin1
  • Incidental Mutations
Mice homozygous for a knock-out allele display abnormalities in object recognition memory and motor learning, dendritic spine disorganization, impaired synaptic plasticity, and reduced long term potentiation and long term depression.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Other Mouse Links
  • Other Vertebrate Links
    Xenbase srcin1
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002720 VEGA Gene Model | MGI Sequence Detail 66847 C57BL/6J ±  kb
transcript OTTMUST00000005390 VEGA | MGI Sequence Detail 7054 Not Applicable  
polypeptide OTTMUSP00000002552 VEGA | MGI Sequence Detail 1217 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    236 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000012187 src kinase signaling inhibitor 1
  • InterPro Domains
    IPR022782 Actin interacting protein 3, C-terminal
    IPR026727 SRC kinase signalling inhibitor 1
Molecular
Reagents
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  • All nucleic 18
    cDNA 18

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
  • Latest
    J:206962 Repetto D, et al., p140Cap regulates memory and synaptic plasticity through Src-mediated and citron-N-mediated actin reorganization. J Neurosci. 2014 Jan 22;34(4):1542-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory