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Pik3ap1 Gene Detail
Summary
  • Symbol
    Pik3ap1
  • Name
    phosphoinositide-3-kinase adaptor protein 1
  • Synonyms
    1810044J04Rik, BCAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933177
    NCBI Gene: 83490
  • Gene Overview
    MyGene.info: PIK3AP1
Location & Maps
more
  • Sequence Map
    Chr19:41274218-41385070 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      110853 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 34.61 cM, cytoband D1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PIK3AP1, phosphoinositide-3-kinase adaptor protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIK3AP1, phosphoinositide-3-kinase adaptor protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BCAP
  • Links
    NCBI Gene ID: 118788
    neXtProt AC: NX_Q6ZUJ8

  • Chr Location
    10q24.1; chr10:96593312-96720522 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (ENU)
    1
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for disruptions in this gene have abnormalities in B cell maturation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025017 Ensembl Gene Model | MGI Sequence Detail 110853 C57BL/6J ±  kb
transcript ENSMUST00000059672 Ensembl | MGI Sequence Detail 2615 Not Applicable  
polypeptide ENSMUSP00000052777 Ensembl | MGI Sequence Detail 811 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    975 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000012714 phosphoinositide 3-kinase adapter protein 1
  • InterPro Domains
    IPR017893 DBB domain
Molecular
Reagents
less
  • All nucleic 39
    cDNA 39

    Microarray probesets 4
Other
Accession IDs
less
MGI:1919285
References
more
  • Summaries
    All 32
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:66479 Okada T, et al., BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity. 2000 Dec;13(6):817-27
  • Latest
    J:185495 Arnold CN, et al., A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. Proc Natl Acad Sci U S A. 2012 Jul 3;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory