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Pik3ap1 Gene Detail
Summary
  • Symbol
    Pik3ap1
  • Name
    phosphoinositide-3-kinase adaptor protein 1
  • Synonyms
    1810044J04Rik, BCAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933177
    NCBI Gene: 83490
  • Gene Overview
    MyGene.info: PIK3AP1
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:41274218-41385070 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 34.61 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    975 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933177
protein coding gene Chr19:41272541-41385070 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025122
protein coding gene Chr19:40538503-40659126 (-)
A/J MGP_AJ_G0025099
protein coding gene Chr19:38589168-38704406 (-)
AKR/J MGP_AKRJ_G0025067
protein coding gene Chr19:39867825-39982494 (-)
BALB/cJ MGP_BALBcJ_G0025093
protein coding gene Chr19:38640818-38758335 (-)
C3H/HeJ MGP_C3HHeJ_G0024853
protein coding gene Chr19:40004085-40121709 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025537
protein coding gene Chr19:41622035-41740408 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022950
protein coding gene Chr19:37955552-38068174 (-)
CAST/EiJ MGP_CASTEiJ_G0024318
protein coding gene Chr19:39646622-39763406 (-)
CBA/J MGP_CBAJ_G0024833
protein coding gene Chr19:43638908-43765279 (-)
DBA/2J MGP_DBA2J_G0024965
protein coding gene Chr19:38450868-38562611 (-)
FVB/NJ MGP_FVBNJ_G0024926
protein coding gene Chr19:38210969-38325004 (-)
LP/J MGP_LPJ_G0025051
protein coding gene Chr19:40549108-40664696 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024957
protein coding gene Chr19:43292755-43411483 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025594
protein coding gene Chr19:39893537-40012819 (-)
PWK/PhJ MGP_PWKPhJ_G0024068
protein coding gene Chr19:38311197-38423874 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023871
protein coding gene Chr19:38627481-38742688 (-)
WSB/EiJ MGP_WSBEiJ_G0024388
protein coding gene Chr19:40061280-40177342 (-)



Homology
more
  • Human Ortholog
    PIK3AP1, phosphoinositide-3-kinase adaptor protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIK3AP1, phosphoinositide-3-kinase adaptor protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCAP
  • Links
    NCBI Gene ID: 118788
    neXtProt AC: NX_Q6ZUJ8
    UniProt: Q6ZUJ8

  • Chr Location
    10q24.1; chr10:96593312-96720522 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have abnormalities in B cell maturation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025017 Ensembl Gene Model | MGI Sequence Detail 110853 C57BL/6J ±  kb
transcript ENSMUST00000059672 Ensembl | MGI Sequence Detail 2615 Not Applicable  
polypeptide ENSMUSP00000052777 Ensembl | MGI Sequence Detail 811 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 40
    cDNA 40

    Microarray probesets 4
Other
Accession IDs
less
MGI:1919285
References
more
  • Summaries
    All 39
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:66479 Okada T, et al., BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity. 2000 Dec;13(6):817-27
  • Latest
    J:266280 Singh MD, et al., B cell adaptor for PI3-kinase (BCAP) modulates CD8(+) effector and memory T cell differentiation. J Exp Med. 2018 Sep 3;215(9):2429-2443

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory