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Trim2
Gene Detail
Symbol

Name
ID
Trim2
tripartite motif-containing 2
MGI:1933163
Synonyms
narf, neural activity-related ring finger protein
Feature Type
protein coding gene
Genetic Map
Chromosome 3
37.48 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:84160439-84305446 bp, - strand
From VEGA annotation of GRCm38

  145008 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22882  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tripartite motif protein 2
Gene Tree: Trim2

Human
homologs
Human Homolog TRIM2, tripartite motif containing 2
NCBI Gene ID 23321
neXtProt AC  NX_Q9C040
Human Synonyms  CMT2R, RNF86
Human Chr (Location)  4q31.3; chr4:153153118-153339322 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TRIM2
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(19) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit tremors, ataxia and seizures associated with neurodegeneration of Purkinje cells, deep cerebellar nuclei and retinal ganglion cells.
 
Interactions
Trim2 interacts with 468 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (418)    Tissues (131)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 382
RT-PCR 36
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(12)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017469 VEGA Gene Model | MGI Sequence Detail 145008 C57BL/6J ±  kb
transcript OTTMUST00000042446 VEGA | MGI Sequence Detail 3816 Not Applicable 
polypeptide OTTMUSP00000019078 VEGA | MGI Sequence Detail 770 Not Applicable 

For the selected sequences
All sequences(153) RefSeq(26) UniProt(17)
Polymorphisms
SNPs within 2kb(847 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003649 B-box, C-terminal
InterPro IPR001298 Filamin/ABP280 repeat
InterPro IPR017868 Filamin/ABP280 repeat-like
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR001258 NHL repeat
InterPro IPR013017 NHL repeat, subgroup
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
InterPro IPR000315 Zinc finger, B-box
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000016646 tripartite motif-containing protein 2
References
(Earliest) J:68594 Ohkawa N, et al., Molecular cloning and characterization of neural activity-related RING finger protein (NARF): a new member of the RBCC family is a candidate for the partner of myosin V. J Neurochem. 2001 Jul;78(1):75-87
(Latest) J:177231 Thompson S, et al., Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. J Biol Chem. 2011 Jun 3;286(22):19331-9
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory