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Trim2 Gene Detail
Summary
  • Symbol
    Trim2
  • Name
    tripartite motif-containing 2
  • Synonyms
    narf, neural activity-related ring finger protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933163
    NCBI Gene: 80890
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:84160439-84306877 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      146439 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 37.48 cM, cytoband F1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TRIM2, tripartite motif containing 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TRIM2, tripartite motif containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMT2R, RNF86
  • Links
    NCBI Gene ID: 23321
    neXtProt AC: NX_Q9C040
    UniProt: Q9C040

  • Chr Location
    4q31.3; chr4:153152281-153339322 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TRIM2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit tremors, ataxia and seizures associated with neurodegeneration of Purkinje cells, deep cerebellar nuclei and retinal ganglion cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000017469 VEGA Gene Model | MGI Sequence Detail 146439 C57BL/6J ±  kb
    transcript OTTMUST00000042446 VEGA | MGI Sequence Detail 3816 Not Applicable  
    polypeptide OTTMUSP00000019078 VEGA | MGI Sequence Detail 770 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      840 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Primer pair 1

      Microarray probesets 12
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:68594 Ohkawa N, et al., Molecular cloning and characterization of neural activity-related RING finger protein (NARF): a new member of the RBCC family is a candidate for the partner of myosin V. J Neurochem. 2001 Jul;78(1):75-87
    • Latest
      J:177231 Thompson S, et al., Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. J Biol Chem. 2011 Jun 3;286(22):19331-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory