About   Help   FAQ
Gene Detail
tripartite motif-containing 2
Synonyms narf, neural activity-related ring finger protein
Feature Type protein coding gene
Genetic Map
Chromosome 3
37.48 cM, cytoband F1
Detailed Genetic Map ± 1 cM

Mapping data(3)
Sequence Map
Chr3:84160439-84305446 bp, - strand
From VEGA annotation of GRCm38

  145008 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:22882  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tripartite motif protein 2
Gene Tree: Trim2

Human Homolog TRIM2, tripartite motif containing 2
NCBI Gene ID 23321
neXtProt AC  NX_Q9C040
Human Synonyms  CMT2R, RNF86
Human Chr (Location)  4q31.3; chr4:153153118-153339322 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TRIM2
alleles, and
All mutations/alleles(22) : Gene trapped(19) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a gene trapped allele exhibit tremors, ataxia and seizures associated with neurodegeneration of Purkinje cells, deep cerebellar nuclei and retinal ganglion cells.
Trim2 interacts with 468 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (24 annotations)
Process protein ubiquitination, regulation of neuron apoptotic process
Component cytoplasm, intracellular
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Literature Summary: (8 records)
Data Summary: Results (418)    Tissues (131)    Images (43)
Theiler Stages: 2, 3, 16, 19, 21, 23, 27, 28
Assay TypeResults
RNA in situ 382
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(23) cDNA(22) Primer pair(1)
Microarray probesets(12)
Other database
VEGA Gene ModelOTTMUSG00000017469 (Evidence)
Ensembl Gene ModelENSMUSG00000027993 (Evidence)
Entrez Gene80890 (Evidence)
DFCITC1574457, TC1593483, TC1602906, TC1610896, TC1662907, TC1704126, TC1713974, TC1753464
DoTSDT.101239300, DT.101252575, DT.101399449, DT.101738861, DT.111066645, DT.111066710, DT.111066748, DT.111066833, DT.60107560, DT.91333860, DT.91348934, DT.91371422, DT.97350381
Consensus CDS ProjectCCDS17437.2, CCDS71256.1, CCDS71257.1
International Mouse Knockout Project StatusTrim2
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017469 VEGA Gene Model | MGI Sequence Detail 145008 C57BL/6J ±  kb
transcript OTTMUST00000042446 VEGA | MGI Sequence Detail 3816 Not Applicable 
polypeptide OTTMUSP00000019078 VEGA | MGI Sequence Detail 770 Not Applicable 

For the selected sequences
All sequences(145) RefSeq(26) UniProt(9)
Polymorphisms SNPs within 2kb(847 from dbSNP Build 137)
InterPro IPR003649 B-box, C-terminal
InterPro IPR001298 Filamin/ABP280 repeat
InterPro IPR017868 Filamin/ABP280 repeat-like
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR001258 NHL repeat
InterPro IPR013017 NHL repeat, subgroup
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
InterPro IPR000315 Zinc finger, B-box
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
Protein Ontology PR:000016646 tripartite motif-containing protein 2
References (Earliest) J:68594 Ohkawa N, et al., Molecular cloning and characterization of neural activity-related RING finger protein (NARF): a new member of the RBCC family is a candidate for the partner of myosin V. J Neurochem. 2001 Jul;78(1):75-87
(Latest) J:177231 Thompson S, et al., Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. J Biol Chem. 2011 Jun 3;286(22):19331-9
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.19
The Jackson Laboratory