Pgam2
Gene Detail

Symbol Name ID

Pgam2 phosphoglycerate mutase 2 MGI:1933118

Feature Type

protein coding gene

Genetic Map

Chromosome 11

3.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:5801640-5803733 bp, - strand From VEGA annotation of GRCm38   2094 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56228  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: cofactor-dependent phosphoglycerate mutase
Gene Tree: Pgam2

Human homologs

Human Homolog		PGAM2, phosphoglycerate mutase 2 (muscle)
NCBI Gene ID		5224
neXtProt AC		NX_P15259
Human Synonyms		GSD10, PGAMM, PGAM-M
Human Chr (Location)		7p13-p12; chr7:44102326-44105186 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PGAM2

Alleles and phenotypes

All alleles(5) : Targeted(1) Gene trapped(4)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	gluconeogenesis, glycolysis, ...
Component	cytosol, nucleus
Function	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity, bisphosphoglycerate 2-phosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (381)    Tissues (119)    Images (57)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	379
RT-PCR	2

cDNA source data(5)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(5) Primer pair(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005095 (Evidence)
Ensembl Gene Model	ENSMUSG00000020475 (Evidence)
Entrez Gene	56012 (Evidence)
DFCI	TC1578210, TC1679293
DoTS	DT.535537, DT.55283488, DT.94404635
NIA Mouse Gene Index	U032474
EC	3.1.3.13, 5.4.2.1, 5.4.2.4
Consensus CDS Project	CCDS24404.1
International Mouse Knockout Project Status	Pgam2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005095	VEGA Gene Model | MGI Sequence Detail	2094	C57BL/6J
transcript	OTTMUST00000011391	VEGA | MGI Sequence Detail	840	Not Applicable
polypeptide	OTTMUSP00000005308	VEGA | MGI Sequence Detail	253	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(27 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013078	Histidine phosphatase superfamily, clade-1
InterPro	IPR001345	Phosphoglycerate/bisphosphoglycerate mutase, active site
InterPro	IPR005952	Phosphoglycerate mutase 1
Protein Ontology	PR:000012593	phosphoglycerate mutase 2

References

(Earliest) J:68108 Zhang J, et al., Mouse phosphoglycerate mutase M and B isozymes: cDNA cloning, enzyme activity assay and mapping. Gene. 2001 Feb 21;264(2):273-9
(Latest) J:178379 Richard AF, et al., Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Dev Biol. 2011 Nov 15;359(2):303-20
All references(35)