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Apobec3
Gene Detail
Symbol

Name
ID
Apobec3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
MGI:1933111
Synonyms
CEM15, Gm20117, MGC:7002, Rfv3, Rfv-3
Feature Type
protein coding gene
Genetic Map
Chromosome 15
37.85 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr15:79891659-79915906 bp, + strand
From VEGA annotation of GRCm38

  24248 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:105420  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: APOBEC3B
Gene Tree: Apobec3

Human
homologs
APOBEC3B, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9582
neXtProt AC: NX_Q9UH17

Human Synonyms: A3B, APOBEC1L, ARCD3, ARP4, bK150C2.2, DJ742C19.2, PHRBNL

Human Chr (Location): 22q13.1-q13.2; chr22:38982399-38992779 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(111) : Gene trapped(107) Radiation induced(1) Spontaneous(1) Targeted(2)
Genomic Mutations involving Apobec3 (1)
Incidental mutations (data from CvDC )
 
Mice homozygous for a gene trapped allele display more rapid and extensive spread of viral infection.
 
Phenotype Images(2)
Interactions
Apobec3 interacts with 232 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (3 records)
Data Summary: Results (108)    Tissues (96)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 108
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(14) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000042090 (Evidence)
Ensembl Gene Model ENSMUSG00000009585 (Evidence)
Entrez Gene 80287 (Evidence)
DFCI TC1577500, TC1586612, TC1591167
EC 3.5.4.-
Consensus CDS Project CCDS27654.1, CCDS49669.1
International Mouse Phenotyping Consortium Status Apobec3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042090 VEGA Gene Model | MGI Sequence Detail 24248 C57BL/6J ±  kb
transcript OTTMUST00000110378 VEGA | MGI Sequence Detail 1953 Not Applicable 
polypeptide OTTMUSP00000061562 VEGA | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(111) RefSeq(8) UniProt(21)
Polymorphisms
SNPs within 2kb(439 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016192 APOBEC/CMP deaminase, zinc-binding
InterPro IPR007904 APOBEC-like, C-terminal
InterPro IPR013158 APOBEC-like, N-terminal
InterPro IPR016193 Cytidine deaminase-like
Protein Ontology PR:000004573 DNA dC->dU-editing enzyme APOBEC-3
References
(Earliest) J:6107 Chesebro B, et al., Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex. Proc Natl Acad Sci U S A. 1979 Jan;76(1):425-9
(Latest) J:219224 Warren CJ, et al., APOBEC3A functions as a restriction factor of human papillomavirus. J Virol. 2015 Jan;89(1):688-702
All references(67)
Other
accession IDs
MGD-MRK-13854, MGD-MRK-13857, MGI:5012302, MGI:97907

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory