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Apobec3 Gene Detail
Summary
  • Symbol
    Apobec3
  • Name
    apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
  • Synonyms
    CEM15, Gm20117, MGC:7002, Rfv3, Rfv-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933111
    NCBI Gene: 80287
  • Gene Overview
    MyGene.info: APOBEC3B
Location & Maps
more
  • Sequence Map
    Chr15:79891659-79915906 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24248 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.85 cM, cytoband E2
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    APOBEC3B, apolipoprotein B mRNA editing enzyme catalytic subunit 3B
  • Vertebrate Orthologs
    6
  • Human Ortholog
    APOBEC3B, apolipoprotein B mRNA editing enzyme catalytic subunit 3B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A3B, APOBEC1L, ARCD3, ARP4, bK150C2.2, DJ742C19.2, PHRBNL
  • Links
    NCBI Gene ID: 9582
    neXtProt AC: NX_Q9UH17

  • Chr Location
    22q13.1-q13.2; chr22:38982399-38992779 (+)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    113
  • Chemically induced (other)
    1
  • Gene trapped
    107
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Apobec3
  • Incidental Mutations
Mice homozygous for a gene trapped allele display more rapid and extensive spread of viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042090 VEGA Gene Model | MGI Sequence Detail 24248 C57BL/6J ±  kb
transcript OTTMUST00000110378 VEGA | MGI Sequence Detail 1953 Not Applicable  
polypeptide OTTMUSP00000061562 VEGA | MGI Sequence Detail 440 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    436 from dbSNP Build 142
Protein
Information
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  • UniProt
    23 Sequences
  • Protein Ontology
    PR:000004573 DNA dC->dU-editing enzyme APOBEC-3
  • EC
  • InterPro Domains
    IPR016192 APOBEC/CMP deaminase, zinc-binding
    IPR013158 APOBEC-like, N-terminal
    IPR002125 Cytidine and deoxycytidylate deaminases, zinc-binding
    IPR016193 Cytidine deaminase-like
Molecular
Reagents
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  • All nucleic 16
    Genomic 1
    cDNA 14
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-13854, MGD-MRK-13857, MGI:5012302, MGI:97907
References
more
  • Summaries
    All 67
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 8
    Phenotypes 53
  • Earliest
    J:6107 Chesebro B, et al., Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex. Proc Natl Acad Sci U S A. 1979 Jan;76(1):425-9
  • Latest
    J:223250 Beck-Engeser GB, et al., APOBEC3 enzymes restrict marginal zone B cells. Eur J Immunol. 2015 Mar;45(3):695-704

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory