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Apobec3
Gene Detail
 Symbol
Name
ID
Apobec3
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
MGI:1933111
Synonyms CEM15, Gm20117, MGC:7002, Rfv3, Rfv-3
Feature Type protein coding gene
Genetic Map
Chromosome 15
37.85 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr15:79891659-79915906 bp, + strand
From VEGA annotation of GRCm38

  24248 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:105420  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Apobec3

Human
homologs
Human Homolog APOBEC3B, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
NCBI Gene ID 9582
neXtProt AC  NX_Q9UH17
Human Synonyms  A3B, APOBEC1L, ARCD3, ARP4, bK150C2.2, DJ742C19.2, PHRBNL
Human Chr (Location)  22q13.1-q13.2; chr22:38982399-38992779 (+)  GRCh38
Alleles
and
phenotypes
All alleles(111) : Gene trapped(107) Spontaneous(1) Targeted(2)
 
Mice homozygous for a gene trapped allele display more rapid and extensive spread of viral infection.
 
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process defense response to virus, hematopoietic progenitor cell differentiation, ...
Component cytoplasm, nucleus
Function 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity, archaeal-specific GTP cyclohydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (108)    Tissues (96)    Images (28)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 108
cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(12) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000042090 (Evidence)
Ensembl Gene ModelENSMUSG00000009585 (Evidence)
Entrez Gene80287 (Evidence)
DFCITC1577500, TC1586612, TC1591167
EC3.5.4.-
Consensus CDS ProjectCCDS27654.1, CCDS49669.1
International Mouse Knockout Project StatusApobec3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042090 VEGA Gene Model | MGI Sequence Detail 24248 C57BL/6J ±  kb
transcript OTTMUST00000110378 VEGA | MGI Sequence Detail 1953 Not Applicable 
polypeptide OTTMUSP00000061562 VEGA | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(113) RefSeq(12) UniProt(21)
Polymorphisms SNPs within 2kb(439 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016192 APOBEC/CMP deaminase, zinc-binding
InterPro IPR007904 APOBEC-like, C-terminal
InterPro IPR013158 APOBEC-like, N-terminal
InterPro IPR016193 Cytidine deaminase-like
Protein Ontology PR:000004573 DNA dC->dU-editing enzyme APOBEC-3
References (Earliest) J:6107 Chesebro B, et al., Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex. Proc Natl Acad Sci U S A. 1979 Jan;76(1):425-9
(Latest) J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17
All references(65)
Other
accession IDs
MGD-MRK-13854, MGD-MRK-13857, MGI:5012302, MGI:97907

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory