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Lamtor2
Gene Detail
 Symbol
Name
ID
Lamtor2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
MGI:1932697
Synonyms 2010111E04Rik, Mapbpip, P14, Rab25, Robld3
Feature Type protein coding gene
Genetic Map
Chromosome 3
38.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:88549819-88553074 bp, - strand
From VEGA annotation of GRCm38

  3256 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8518  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lamtor2

Human
homologs
Human Homolog LAMTOR2, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
NCBI Gene ID 28956
neXtProt AC  NX_Q9Y2Q5
Human Synonyms  ENDAP, HSPC003, MAPBPIP, MAPKSP1AP, p14, Ragulator2, ROBLD3
Human Chr (Location)  1q22; chr1:156054726-156058510 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LAMTOR2
Mutations,
alleles, and
phenotypes
All mutations/alleles(49) : Gene trapped(44) Targeted(5)
 
Embryos homozygous for a knock-out allele display severe developmental defects, are growth retarded and die prior to E10.5.
 
Interactions
Lamtor2 interacts with 8 markers (Mir188, Mir204, Mir211, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process activation of MAPKK activity, cell growth, ...
Component endosome, extracellular vesicular exosome, ...
Function guanyl-nucleotide exchange factor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(80)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(80) cDNA(80)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028880 (Evidence)
Ensembl Gene ModelENSMUSG00000028062 (Evidence)
Entrez Gene83409 (Evidence)
UniGene41680
DFCITC1578553, TC1665793
DoTSDT.494215, DT.50316412
NIA Mouse Gene IndexU024258
PDB1SKO, 1SZV, 1VET, 1VEU, 3CPT, 2ZL1
Consensus CDS ProjectCCDS17478.1
International Mouse Knockout Project StatusLamtor2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028880 VEGA Gene Model | MGI Sequence Detail 3256 C57BL/6J ±  kb
transcript OTTMUST00000071568 VEGA | MGI Sequence Detail 668 Not Applicable 
polypeptide OTTMUSP00000036705 VEGA | MGI Sequence Detail 125 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004942 Dynein light chain-related
Protein Ontology PR:000014150 ragulator complex protein LAMTOR2
References (Earliest) J:61077 Bhartur SG, et al., Genomic structure of murine Rab11 family members. Biochem Biophys Res Commun. 2000 Mar 16;269(2):611-7
(Latest) J:206480 Sparber F, et al., The late endosomal adaptor molecule p14 (LAMTOR2) represents a novel regulator of Langerhans cell homeostasis. Blood. 2014 Jan 9;123(2):217-27
All references(43)
Other
accession IDs
MGI:1913801, MGI:2144920

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory