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Lamtor2
Gene Detail
Symbol

Name
ID
Lamtor2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
MGI:1932697
Synonyms
2010111E04Rik, Mapbpip, P14, Rab25, Robld3
Feature Type
protein coding gene
Genetic Map
Chromosome 3
38.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:88549819-88553074 bp, - strand
From VEGA annotation of GRCm38

  3256 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8518  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LAMTOR2
Gene Tree: Lamtor2

Human
homologs
LAMTOR2, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 28956
neXtProt AC: NX_Q9Y2Q5

Human Synonyms: ENDAP, HSPC003, MAPBPIP, MAPKSP1AP, p14, Ragulator2, ROBLD3

Human Chr (Location): 1q22; chr1:156054726-156058510 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LAMTOR2

Mutations,
alleles, and
phenotypes
All mutations/alleles(49) : Gene trapped(44) Targeted(5)
 
Embryos homozygous for a knock-out allele display severe developmental defects, are growth retarded and die prior to E10.5.
 
Interactions
Lamtor2 interacts with 8 markers (Mir188, Mir204, Mir211, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process activation of MAPKK activity, cell growth, ...
Component endosome, extracellular exosome, ...
Function guanyl-nucleotide exchange factor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(80)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lamtor2    NEW 
Molecular
reagents
All nucleic(80) cDNA(80)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000028880 (Evidence)
Ensembl Gene Model ENSMUSG00000028062 (Evidence)
Entrez Gene 83409 (Evidence)
UniGene 41680
DFCI TC1665793, TC1578553
DoTS DT.50316412, DT.494215
NIA Mouse Gene Index U024258
PDB 1SKO, 1SZV, 1VET, 1VEU, 3CPT, 2ZL1
Consensus CDS Project CCDS17478.1
International Mouse Phenotyping Consortium Status Lamtor2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028880 VEGA Gene Model | MGI Sequence Detail 3256 C57BL/6J ±  kb
transcript OTTMUST00000071568 VEGA | MGI Sequence Detail 668 Not Applicable 
polypeptide OTTMUSP00000036705 VEGA | MGI Sequence Detail 125 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004942 Dynein light chain-related
Protein Ontology PR:000014150 ragulator complex protein LAMTOR2
References
(Earliest) J:61077 Bhartur SG, et al., Genomic structure of murine Rab11 family members. Biochem Biophys Res Commun. 2000 Mar 16;269(2):611-7
(Latest) J:216190 Sparber F, et al., The Late Endosomal Adaptor Molecule p14 (LAMTOR2) Regulates TGFbeta1-Mediated Homeostasis of Langerhans Cells. J Invest Dermatol. 2015 Jan;135(1):119-29
All references(43)
Other
accession IDs
MGI:1913801, MGI:2144920

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory