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Lamtor2 Gene Detail
Summary
  • Symbol
    Lamtor2
  • Name
    late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
  • Synonyms
    2010111E04Rik, Mapbpip, P14, Rab25, Robld3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932697
    NCBI Gene: 83409
Location & Maps
more
  • Sequence Map
    Chr3:88549819-88553074 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3256 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.87 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LAMTOR2, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LAMTOR2, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ENDAP, HSPC003, MAPBPIP, MAPKSP1AP, p14, Ragulator2, ROBLD3
  • Links
    NCBI Gene ID: 28956
    neXtProt AC: NX_Q9Y2Q5

  • Chr Location
    1q22; chr1:156054726-156058510 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human LAMTOR2 associations

Human Disease Mouse Models
       Immunodeficiency Due to Defect in Mapbp-Interacting Protein   OMIM: 610798
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    51
  • Chemically induced (other)
    1
  • Gene trapped
    44
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Lamtor2
Embryos homozygous for a knock-out allele display severe developmental defects, are growth retarded and die prior to E10.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028880 VEGA Gene Model | MGI Sequence Detail 3256 C57BL/6J ±  kb
transcript OTTMUST00000071568 VEGA | MGI Sequence Detail 668 Not Applicable  
polypeptide OTTMUSP00000036705 VEGA | MGI Sequence Detail 125 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    7 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 80
    cDNA 80

    Microarray probesets 3
Other
Accession IDs
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MGI:1913801, MGI:2144920
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:61077 Bhartur SG, et al., Genomic structure of murine Rab11 family members. Biochem Biophys Res Commun. 2000 Mar 16;269(2):611-7
  • Latest
    J:216190 Sparber F, et al., The Late Endosomal Adaptor Molecule p14 (LAMTOR2) Regulates TGFbeta1-Mediated Homeostasis of Langerhans Cells. J Invest Dermatol. 2015 Jan;135(1):119-29

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory