Lamtor2
Gene Detail

Symbol Name ID

Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 MGI:1932697

Synonyms

2010111E04Rik, Mapbpip, P14, Rab25, Robld3

Feature Type

protein coding gene

Genetic Map

Chromosome 3

38.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:88549819-88553074 bp, - strand From VEGA annotation of GRCm38   3256 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8518  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lamtor2

Human homologs

Human Homolog		LAMTOR2, late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
NCBI Gene ID		28956
neXtProt AC		NX_Q9Y2Q5
Human Synonyms		ENDAP, HSPC003, MAPBPIP, MAPKSP1AP, p14, Ragulator2, ROBLD3
Human Chr (Location)		1q22; chr1:156024517-156028301 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LAMTOR2

Alleles and phenotypes

All alleles(48) : Targeted(4) Gene trapped(44)
 

Embryos homozygous for a knock-out allele display severe developmental defects, are growth retarded and die prior to E10.5.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	activation of MAPKK activity, cell growth, ...
Component	endosome, late endosome, ...
Function	guanyl-nucleotide exchange factor activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(80)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(80) cDNA(80)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000028880 (Evidence)
Ensembl Gene Model	ENSMUSG00000028062 (Evidence)
Entrez Gene	83409 (Evidence)
UniGene	41680
DFCI	TC1578553, TC1665793
DoTS	DT.494215, DT.50316412
NIA Mouse Gene Index	U024258
PDB	1SKO, 1SZV, 1VET, 1VEU, 3CPT, 2ZL1
Consensus CDS Project	CCDS17478.1
International Mouse Knockout Project Status	Lamtor2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028880	VEGA Gene Model | MGI Sequence Detail	3256	C57BL/6J
transcript	OTTMUST00000071568	VEGA | MGI Sequence Detail	668	Not Applicable
polypeptide	OTTMUSP00000036705	VEGA | MGI Sequence Detail	125	Not Applicable

All sequences(36) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(5 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004942	Dynein light chain-related
Protein Ontology	PR:000014150	ragulator complex protein LAMTOR2

References

(Earliest) J:61077 Bhartur SG, et al., Genomic structure of murine Rab11 family members. Biochem Biophys Res Commun. 2000 Mar 16;269(2):611-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)

Other accession IDs

MGI:1913801, MGI:2144920