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Cxcl16 Gene Detail
Summary
  • Symbol
    Cxcl16
  • Name
    chemokine (C-X-C motif) ligand 16
  • Synonyms
    0910001K24Rik, Scavenger Receptor, SR-PSOX, SR-PSOX/CXCL16
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932682
    NCBI Gene: 66102
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70454232-70459984 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.99 cM, cytoband B4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932682
protein coding gene Chr11:70453983-70459984 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018596
protein coding gene Chr11:70988059-70994141 (-)
A/J MGP_AJ_G0018564
protein coding gene Chr11:68294231-68299834 (-)
AKR/J MGP_AKRJ_G0018533
protein coding gene Chr11:70342993-70350022 (-)
BALB/cJ MGP_BALBcJ_G0018536
protein coding gene Chr11:68613571-68619185 (-)
C3H/HeJ MGP_C3HHeJ_G0018349
protein coding gene Chr11:70365166-70371946 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018987
protein coding gene Chr11:73127907-73133642 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016632
protein coding gene Chr11:65219714-65226365 (-)
CAST/EiJ MGP_CASTEiJ_G0017904
protein coding gene Chr11:70621736-70627397 (-)
CBA/J MGP_CBAJ_G0018321
protein coding gene Chr11:76403453-76409104 (-)
DBA/2J MGP_DBA2J_G0018431
protein coding gene Chr11:67877918-67883912 (-)
FVB/NJ MGP_FVBNJ_G0018421
protein coding gene Chr11:67522408-67528446 (-)
LP/J MGP_LPJ_G0018501
protein coding gene Chr11:71559069-71564692 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018444
protein coding gene Chr11:76989778-76996995 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019029
protein coding gene Chr11:70607389-70613130 (-)
PWK/PhJ MGP_PWKPhJ_G0017678
protein coding gene Chr11:68516637-68522863 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017468
protein coding gene Chr11:70414071-70421078 (-)
WSB/EiJ MGP_WSBEiJ_G0017958
protein coding gene Chr11:70267737-70273294 (-)



Homology
more
  • Human Ortholog
    CXCL16, C-X-C motif chemokine ligand 16
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CXCL16, C-X-C motif chemokine ligand 16
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CXCLG16, SRPSOX, SR-PSOX
  • Links
    NCBI Gene ID: 58191
    neXtProt AC: NX_Q9H2A7
    UniProt: Q9H2A7

  • Chr Location
    17p13.2; chr17:4733529-4739928 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased NK T cells, decreased secretion and serum levels of IL4 and IFN-gamma, and decreased inhibition of B16 melanoma cell growth by alpha-galactosylceramide treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66102 NCBI Gene Model | MGI Sequence Detail 5753 C57BL/6J ±  kb
    transcript NR_151497 RefSeq | MGI Sequence Detail 1692 C57BL/6  
    polypeptide Q8BSU2 UniProt | EBI | MGI Sequence Detail 246 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1913352, MGI:2144468, MGI:2144594
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:263080 Sakuma Y, et al., Chemokine CXCL16 mediates acinar cell necrosis in cerulein induced acute pancreatitis in mice. Sci Rep. 2018 Jun 11;8(1):8829

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory