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Letm1 Gene Detail
Summary
  • Symbol
    Letm1
  • Name
    leucine zipper-EF-hand containing transmembrane protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932557
    NCBI Gene: 56384
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:33897017-33940061 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1096 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932557
 protein coding gene Chr5:33897017-33940161 (-)
129S1/SvImJ ENSMUSG00200014103
 protein coding gene Chr5:29365653-29408804 (-)
A/J ENSMUSG00195045778
 protein coding gene Chr5:28843347-28886466 (-)
AKR/J ENSMUSG00220008514
 protein coding gene Chr5:28863781-28906897 (-)
BALB/cJ ENSMUSG00180036315
 protein coding gene Chr5:28646297-28689420 (-)
C3H/HeJ ENSMUSG00175048048
 protein coding gene Chr5:30625898-30669014 (-)
C57BL/6NJ ENSMUSG00215033258
 protein coding gene Chr5:29362806-29405951 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027121
 protein coding gene Chr5:28694059-28737974 (-)
CAST/EiJ ENSTCUG00005024161
 protein coding gene Chr5:28849232-28891432 (-)
CBA/J ENSMUSG00210047280
 protein coding gene Chr5:29593603-29636719 (-)
DBA/2J ENSMUSG00185016873
 protein coding gene Chr5:31458069-31500346 (-)
FVB/NJ ENSMUSG00205019177
 protein coding gene Chr5:28348845-28391978 (-)
JF1/MsJ ENSUMUG00000045619
 protein coding gene Chr5:36066606-36109517 (-)
LP/J ENSMUSG00230046589
 protein coding gene Chr5:36069329-36112476 (-)
NOD/ShiLtJ ENSMUSG00190014561
 protein coding gene Chr5:28622793-28665926 (-)
NZO/HlLtJ ENSMUSG00225016530
 protein coding gene Chr5:41275552-41318702 (-)
PWK/PhJ ENSLUMG00010045135
 protein coding gene Chr5:28761878-28804752 (-)
SPRET/EiJ ENSMSPG00010040834
 protein coding gene Chr5:29938219-29985584 (-)
WSB/EiJ ENSIUOG00005017712
 protein coding gene Chr5:31552898-31595165 (-)



Homology
more
  • Human Ortholog
    LETM1, leucine zipper and EF-hand containing transmembrane protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LETM1, leucine zipper and EF-hand containing transmembrane protein 1
  • Synonyms
    CONDMIM, KHE, Mdm38, SLC55A1
  • Links
    NCBI Gene ID: 3954
    UniProt: O95202

  • Chr Location
    4p16.3; chr4:1811479-1856232 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous deletion of this gene causes embryonic lethality prior to E6.5 while ~50% of heterozygotes die before E13.5. Surviving heterozygous mice show altered glucose metabolism, impaired control of brain ATP levels, and increased susceptibility to kainic acid-induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    8
  • cDNA Data
    15
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56384 NCBI Gene Model | MGI Sequence Detail 43045 C57BL/6J ±  kb
    transcript NM_019694 RefSeq | MGI Sequence Detail 5188 C57BL/6  
    polypeptide Q9Z2I0 UniProt | EBI | MGI Sequence Detail 738 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Other 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 13
      Phenotypes 27
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:348785 Zhang D, et al., Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos. J Cell Physiol. 2024 Mar 26;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory