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Ndst4 Gene Detail
Summary
  • Symbol
    Ndst4
  • Name
    N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
  • Synonyms
    4930439H17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932545
    NCBI Gene: 64580
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:125404076-125728899 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      324824 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 54.68 cM, cytoband H1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NDST4, N-deacetylase and N-sulfotransferase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NDST4, N-deacetylase and N-sulfotransferase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NDST-4, N-HSST, NHSST4, N-HSST 4
  • Links
    NCBI Gene ID: 64579
    neXtProt AC: NX_Q9H3R1
    UniProt: Q9H3R1

  • Chr Location
    4q26; chr4:114824122-115114098 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a phenotype restricted to the colonic epithelium that includes an increased number of colon goblet cells, a decreased number of colonocytes, and increased apoptosis of colonic epithelial cells in the proximal colon.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000025050 VEGA Gene Model | MGI Sequence Detail 324824 C57BL/6J ±  kb
    transcript OTTMUST00000061638 VEGA | MGI Sequence Detail 7417 Not Applicable  
    polypeptide OTTMUSP00000030274 VEGA | MGI Sequence Detail 872 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      4268 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 8
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1921219
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:252046 Jao TM, et al., Alteration of colonic epithelial cell differentiation in mice deficient for glucosaminyl N-deacetylase/N-sulfotransferase 4. Oncotarget. 2016 Dec 20;7(51):84938-84950

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory