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Ndst3
Gene Detail
Symbol

Name
ID
Ndst3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
MGI:1932544
Synonyms
4921531K01Rik, 4930511P15Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
54.58 cM, cytoband G3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:123526166-123690852 bp, - strand
From VEGA annotation of GRCm38

  164687 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3513  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: heparan sulfate N-sulfotransferase 3
Gene Tree: Ndst3

Human
homologs
Human Homolog NDST3, N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
NCBI Gene ID 9348
neXtProt AC  NX_O95803
Human Synonyms  HSST3
Human Chr (Location)  4q26; chr4:118033522-118258634 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knockout allele exhibit decreased anxiety-related behavior, cholesterol levels and CD8+ T cells due to moderate heparan-sulfate undersulfation.
 
Interactions
Ndst3 interacts with 401 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process metabolic process
Component Golgi apparatus, integral component of membrane, ...
Function 1-hydroxypyrene sulfotransferase activity, 1-phenanthrol sulfotransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (209)    Tissues (152)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 161
RT-PCR 48
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(9) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000025124 (Evidence)
Ensembl Gene ModelENSMUSG00000027977 (Evidence)
Entrez Gene83398 (Evidence)
DFCITC1588302, TC1650917, TC1589651, TC1617882
DoTSDT.97388711, DT.91340246, DT.94214100, DT.55266234, DT.91333778
NIA Mouse Gene IndexU024613
EC2.8.2.8, 2.8.2.-, 3.-.-.-
Consensus CDS ProjectCCDS17818.1
International Mouse Knockout Project StatusNdst3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025124 VEGA Gene Model | MGI Sequence Detail 164687 C57BL/6J ±  kb
transcript OTTMUST00000061799 VEGA | MGI Sequence Detail 5534 Not Applicable 
polypeptide OTTMUSP00000030393 VEGA | MGI Sequence Detail 873 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(17) UniProt(9)
Polymorphisms
SNPs within 2kb(2286 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021930 Heparan sulphate-N-deacetylase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000863 Sulfotransferase domain
Protein Ontology PR:000011065 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:178840 Dagalv A, et al., Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin. J Biol Chem. 2011 Dec 30;286(52):44433-40
All references(39)
Other
accession IDs
MGI:1918208, MGI:1921948

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory