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Siglece Gene Detail
Summary
  • Symbol
    Siglece
  • Name
    sialic acid binding Ig-like lectin E
  • Synonyms
    mSiglec-E, Siglec5, Siglecl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932475
    NCBI Gene: 83382
  • Gene Overview
    MyGene.info: SIGLEC9
Location & Maps
more
  • Sequence Map
    Chr7:43651070-43660161 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9092 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.25 cM, cytoband B2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SIGLEC12, sialic acid binding Ig like lectin 12 (gene/pseudogene)
  • Vertebrate Orthologs
    4
  • Human Ortholog
    SIGLEC12, sialic acid binding Ig like lectin 12 (gene/pseudogene)
    Orthology source: HGNC
  • Synonyms
    S2V, SIGLECL1, Siglec-XII, SLG
  • Links
    NCBI Gene ID: 89858
    neXtProt AC: NX_Q96PQ1

  • Chr Location
    19q13.41; chr19:51491227-51501789 (-)  GRCh38.p2

  • Human Ortholog
    SIGLEC9, sialic acid binding Ig like lectin 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD329, CDw329, FOAP-9, OBBP-LIKE, siglec-9
  • Links
    NCBI Gene ID: 27180
    neXtProt AC: NX_Q9Y336

  • Chr Location
    19q13.41; chr19:51124880-51141020 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele or a knock-in allele that destroys the sialic acid binding site exhibit increased neutrophil and macrophage recruitment in an LPS-induced model of acute lung ariway inflammation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058306 VEGA Gene Model | MGI Sequence Detail 9092 C57BL/6J ±  kb
transcript OTTMUST00000143182 VEGA | MGI Sequence Detail 1849 Not Applicable  
polypeptide OTTMUSP00000074652 VEGA | MGI Sequence Detail 467 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    127 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR013106 Immunoglobulin V-set domain
Molecular
Reagents
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  • All nucleic 8
    Genomic 1
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:67541 Yu Z, et al., mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2. Biochem J. 2001 Feb 1;353(Pt 3):483-92
  • Latest
    J:220809 Schwarz F, et al., Siglec receptors impact mammalian lifespan by modulating oxidative stress. Elife. 2015;4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory