About   Help   FAQ
Siglece Gene Detail
Summary
  • Symbol
    Siglece
  • Name
    sialic acid binding Ig-like lectin E
  • Synonyms
    mSiglec-E, Siglec5, Siglecl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932475
    NCBI Gene: 83382
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43651070-43660161 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.25 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932475
protein coding gene Chr7:43651070-43660176 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032135
protein coding gene Chr7:43679630-43688517 (-)
A/J MGP_AJ_G0032120
protein coding gene Chr7:42778031-42786835 (-)
AKR/J MGP_AKRJ_G0032050
protein coding gene Chr7:44157247-44166215 (-)
BALB/cJ MGP_BALBcJ_G0032125
protein coding gene Chr7:42895088-42904279 (-)
C3H/HeJ MGP_C3HHeJ_G0031841
protein coding gene Chr7:44659388-44668599 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032609
protein coding gene Chr7:45877013-45887311 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029632
protein coding gene Chr7:44908775-44917911 (-)
CAST/EiJ MGP_CASTEiJ_G0031171
protein coding gene Chr7:35833962-35846382 (-)
CBA/J MGP_CBAJ_G0031810
protein coding gene Chr7:47328852-47344247 (-)
DBA/2J MGP_DBA2J_G0031959
protein coding gene Chr7:42585961-42595148 (-)
FVB/NJ MGP_FVBNJ_G0031920
protein coding gene Chr7:42297959-42306945 (-)
LP/J MGP_LPJ_G0032038
protein coding gene Chr7:44410183-44419177 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031956
protein coding gene Chr7:46267189-46275994 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032629
protein coding gene Chr7:43281685-43290762 (-)
PWK/PhJ MGP_PWKPhJ_G0030892
protein coding gene Chr7:36029253-36038340 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030731
protein coding gene Chr7:31330767-31339583 (-)
WSB/EiJ MGP_WSBEiJ_G0031285
protein coding gene Chr7:43827898-43837273 (-)



Homology
more
  • Human Ortholog
    SIGLEC12, sialic acid binding Ig like lectin 12 (gene/pseudogene)
  • Vertebrate Orthologs
    4
  • Human Ortholog
    SIGLEC12, sialic acid binding Ig like lectin 12 (gene/pseudogene)
    Orthology source: HGNC
  • Synonyms
    S2V, SIGLECL1, Siglec-XII, SLG
  • Links
    NCBI Gene ID: 89858
    neXtProt AC: NX_Q96PQ1
    UniProt: Q96PQ1

  • Chr Location
    19q13.41; chr19:51491227-51501789 (-)  GRCh38.p7

  • Human Ortholog
    SIGLEC9, sialic acid binding Ig like lectin 9
    Orthology source: HomoloGene
  • Synonyms
    CD329, CDw329, FOAP-9, OBBP-LIKE, siglec-9
  • Links
    NCBI Gene ID: 27180
    neXtProt AC: NX_Q9Y336
    UniProt: Q9Y336

  • Chr Location
    19q13.41; chr19:51124880-51140480 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele or a knock-in allele that destroys the sialic acid binding site exhibit increased neutrophil and macrophage recruitment in an LPS-induced model of acute lung ariway inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030474 Ensembl Gene Model | MGI Sequence Detail 9092 C57BL/6J ±  kb
    transcript ENSMUST00000032667 Ensembl | MGI Sequence Detail 1849 Not Applicable  
    polypeptide ENSMUSP00000032667 Ensembl | MGI Sequence Detail 467 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
      IPR003599 Immunoglobulin subtype
      IPR003598 Immunoglobulin subtype 2
      IPR013106 Immunoglobulin V-set domain
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 1
      cDNA 8

      Microarray probesets 2
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:67541 Yu Z, et al., mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2. Biochem J. 2001 Feb 1;353(Pt 3):483-92
    • Latest
      J:264224 Schwarz F, et al., Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. EMBO J. 2017 Mar 15;36(6):751-760

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory