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Klb
Gene Detail
Symbol

Name
ID
Klb
klotho beta
MGI:1932466
Synonyms
betaKlotho
Feature Type
protein coding gene
Genetic Map
Chromosome 5
33.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:65348411-65384020 bp, + strand
From NCBI annotation of GRCm38

  35610 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12820  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: KLB
Gene Tree: Klb

Human
homologs
KLB, klotho beta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 152831
neXtProt AC: NX_Q86Z14

Human Synonyms: BKL

Human Chr (Location): 4p14; chr4:39406853-39451533 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(3) Radiation induced(1) Targeted(7)
Genomic Mutations involving Klb (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display increased bile acid synthesis and excretion, resistance to gallstone formation, and slightly decreased body weight. Mice homozygous for a knock-out allele or a conditional allele activated in adipose tissue exhibit resistance to FGF21-induced metabolic disruptions.
 
Phenotype Images(4)
Interactions
Klb interacts with 49 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (45)    Tissues (31)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
Northern blot 17
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase klb    NEW 
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000029195 (Evidence)
Entrez Gene 83379 (Evidence)
UniGene 45274
DFCI TC1584780, TC1592526
DoTS DT.55120357, DT.99640953
NIA Mouse Gene Index U005626, U320501
Consensus CDS Project CCDS19306.1
International Mouse Phenotyping Consortium Status Klb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 83379 NCBI Gene Model | MGI Sequence Detail 35610 C57BL/6J ±  kb
transcript NM_031180 RefSeq | MGI Sequence Detail 3439 C57BL/6 
polypeptide Q99N32 UniProt | EBI | MGI Sequence Detail 1043 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(167 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013781 Glycoside hydrolase, catalytic domain
InterPro IPR001360 Glycoside hydrolase, family 1
InterPro IPR018120 Glycoside hydrolase, family 1, active site
InterPro IPR017853 Glycoside hydrolase superfamily
Protein Ontology PR:000009348 beta-klotho
Graphical View of Protein Domain Structure
References
(Earliest) J:46369 Shiraki-Iida T, et al., Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Lett. 1998 Mar 6;424(1-2):6-10
(Latest) J:215567 Owen BM, et al., FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss. Cell Metab. 2014 Oct 7;20(4):670-7
All references(42)
Other
accession IDs
MGI:2141111

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory