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Klb
Gene Detail
Symbol

Name
ID
Klb
klotho beta
MGI:1932466
Synonyms
betaKlotho
Feature Type
protein coding gene
Genetic Map
Chromosome 5
33.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:65348386-65384003 bp, + strand
From VEGA annotation of GRCm38

  35618 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12820  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Klb

Human
homologs
Human Homolog KLB, klotho beta
NCBI Gene ID 152831
neXtProt AC  NX_Q86Z14
Human Synonyms  BKL
Human Chr (Location)  4p14; chr4:39406853-39451533 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(3) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display increased bile acid synthesis and excretion, resistance to gallstone formation, and slightly decreased body weight. Mice homozygous for a knock-out allele or a conditional allele activated in adipose tissue exhibit resistance to FGF21-induced metabolic disruptions.
 
Interactions
Klb interacts with 49 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Expression
Literature Summary: (4 records)
Data Summary: Results (45)    Tissues (31)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
Northern blot 17
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028376 (Evidence)
Ensembl Gene ModelENSMUSG00000029195 (Evidence)
Entrez Gene83379 (Evidence)
UniGene45274
DFCITC1592526, TC1584780
DoTSDT.55120357, DT.99640953
NIA Mouse Gene IndexU320501, U005626
Consensus CDS ProjectCCDS19306.1
International Mouse Knockout Project StatusKlb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028376 VEGA Gene Model | MGI Sequence Detail 35618 C57BL/6J ±  kb
transcript OTTMUST00000070328 VEGA | MGI Sequence Detail 3464 Not Applicable 
polypeptide OTTMUSP00000035820 VEGA | MGI Sequence Detail 1043 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(167 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013781 Glycoside hydrolase, catalytic domain
InterPro IPR001360 Glycoside hydrolase, family 1
InterPro IPR018120 Glycoside hydrolase, family 1, active site
InterPro IPR017853 Glycoside hydrolase, superfamily
Protein Ontology PR:000009348 beta-klotho
References
(Earliest) J:46369 Shiraki-Iida T, et al., Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Lett. 1998 Mar 6;424(1-2):6-10
(Latest) J:201889 Owen BM, et al., FGF21 contributes to neuroendocrine control of female reproduction. Nat Med. 2013 Sep;19(9):1153-6
All references(43)
Other
accession IDs
MGI:2141111

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory