Homozygous null mice display increased bile acid synthesis and excretion, resistance to gallstone formation, and slightly decreased body weight. Mice homozygous for a knock-out allele or a conditional allele activated in adipose tissue exhibit resistance to FGF21-induced metabolic disruptions.
|Process||carbohydrate metabolic process, fibroblast growth factor receptor signaling pathway, ...|
|Component||integral component of membrane, membrane, ...|
|Function||fibroblast growth factor binding, fibroblast growth factor receptor binding, ...|
|InterPro||IPR013781||Glycoside hydrolase, catalytic domain|
|InterPro||IPR001360||Glycoside hydrolase, family 1|
|InterPro||IPR018120||Glycoside hydrolase, family 1, active site|
|InterPro||IPR017853||Glycoside hydrolase superfamily|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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