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Phip
Gene Detail
 Symbol
Name
ID
Phip
pleckstrin homology domain interacting protein
MGI:1932404
Synonyms 2810004D21Rik, 4632404O06Rik, Ndrp, Wdr11
Feature Type protein coding gene
Genetic Map
Chromosome 9
45.18 cM, cytoband E3.1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:82866159-82975489 bp, - strand
From NCBI annotation of GRCm38

  109331 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41209  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Phip

Human
homologs
Human Homolog PHIP, pleckstrin homology domain interacting protein
NCBI Gene ID 55023
neXtProt AC  NX_Q8WWQ0
Human Synonyms  BRWD2, DCAF14, ndrp, WDR11
Human Chr (Location)  6q14; chr6:78934419-79078294 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Gene trapped(42) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit postnatal and premature lethality associated with reduced body size, small myocardial cells and hepatocytes, hypoglycemia, increased insulin sensitivity, and reduced cell growth.
 
Interactions
Phip interacts with 503 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cytoskeleton organization, insulin receptor signaling pathway, ...
Component cell, extracellular vesicular exosome, ...
Function insulin receptor binding, lysine-acetylated histone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (98)    Tissues (74)    Images (19)
Theiler Stages: 11, 13, 17, 19, 21, 23, 28
Assay TypeResults
RNA in situ 98
cDNA source data(26)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) cDNA(31) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000032253 (Evidence)
Entrez Gene83946 (Evidence)
DFCITC1578032, TC1585338, TC1599021, TC1600172, TC1605421, TC1614551, TC1630496, TC1685508
DoTSDT.101380825, DT.110588357, DT.531701, DT.55202943, DT.55282219, DT.91333414
NIA Mouse Gene IndexU031140
Consensus CDS ProjectCCDS40706.1
International Mouse Knockout Project StatusPhip
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 83946 NCBI Gene Model | MGI Sequence Detail 109331 C57BL/6J ±  kb
transcript NM_001081216 RefSeq | MGI Sequence Detail 10729 Not Specified 
polypeptide Q8VDD9 UniProt | EBI | MGI Sequence Detail 1821 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(11) UniProt(7)
Polymorphisms SNPs within 2kb(433 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001487 Bromodomain
InterPro IPR018359 Bromodomain, conserved site
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000012657 PH-interacting protein
Graphical View of Protein Domain Structure
References (Earliest) J:66427 Farhang-Fallah J, et al., Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein. J Biol Chem. 2000 Dec 22;275(51):40492-7
(Latest) J:196086 Appler JM, et al., Gata3 is a critical regulator of cochlear wiring. J Neurosci. 2013 Feb 20;33(8):3679-91
All references(45)
Other
accession IDs
MGI:1917187, MGI:1921594, MGI:1926949, MGI:1933643

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory