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Phip
Gene Detail
Symbol

Name
ID
Phip
pleckstrin homology domain interacting protein
MGI:1932404
Synonyms
2810004D21Rik, 4632404O06Rik, Ndrp, Wdr11
Feature Type
protein coding gene
Genetic Map
Chromosome 9
45.18 cM, cytoband E3.1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:82866159-82975516 bp, - strand
From VEGA annotation of GRCm38

  109358 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41209  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PHIP
Gene Tree: Phip

Human
homologs
PHIP, pleckstrin homology domain interacting protein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 55023
neXtProt AC: NX_Q8WWQ0

Human Synonyms: BRWD2, DCAF14, ndrp, WDR11

Human Chr (Location): 6q14; chr6:78934419-79078294 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Gene trapped(40) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trapped allele exhibit postnatal and premature lethality associated with reduced body size, small myocardial cells and hepatocytes, hypoglycemia, increased insulin sensitivity, and reduced cell growth.
 
Interactions
Phip interacts with 502 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cytoskeleton organization, insulin receptor signaling pathway, ...
Component cell, extracellular exosome, ...
Function insulin receptor binding, lysine-acetylated histone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (98)    Tissues (82)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 98
cDNA source data(26)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase phip ; ZFIN phip    NEW 
Molecular
reagents
All nucleic(32) cDNA(31) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000044899 (Evidence)
Ensembl Gene Model ENSMUSG00000032253 (Evidence)
Entrez Gene 83946 (Evidence)
DFCI TC1578032, TC1585338, TC1599021, TC1600172, TC1605421, TC1614551, TC1630496, TC1685508
DoTS DT.101380825, DT.110588357, DT.531701, DT.55202943, DT.55282219, DT.91333414
NIA Mouse Gene Index U031140
Consensus CDS Project CCDS40706.1
International Mouse Phenotyping Consortium Status Phip
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044899 VEGA Gene Model | MGI Sequence Detail 109358 C57BL/6J ±  kb
transcript OTTMUST00000118006 VEGA | MGI Sequence Detail 10756 Not Applicable 
polypeptide OTTMUSP00000065911 VEGA | MGI Sequence Detail 1821 Not Applicable 

For the selected sequences
All sequences(110) RefSeq(9) UniProt(10)
Polymorphisms
SNPs within 2kb(433 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001487 Bromodomain
InterPro IPR018359 Bromodomain, conserved site
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR028738 PH-interacting protein
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000012657 PH-interacting protein
References
(Earliest) J:66427 Farhang-Fallah J, et al., Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein. J Biol Chem. 2000 Dec 22;275(51):40492-7
(Latest) J:196086 Appler JM, et al., Gata3 is a critical regulator of cochlear wiring. J Neurosci. 2013 Feb 20;33(8):3679-91
All references(46)
Other
accession IDs
MGI:1917187, MGI:1921594, MGI:1926949, MGI:1933643

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory