Rrbp1 MGI Mouse Gene Detail - MGI:1932395 - ribosome binding protein 1

Symbol

Rrbp1
Name

ribosome binding protein 1
Synonyms

1700087N07Rik, 5730465C04Rik, ES/130, mRRp0, mRRp10, mRRp15a, mRRp15b, mRRp16.8, mRRp1.8, mRRp2, mRRp41, mRRp47, mRRp5.4, p180

Feature Type

protein coding gene
IDs

MGI:1932395
NCBI Gene: 81910
Gene Overview

MyGene.info: RRBP1
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr2:143789315-143853183 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 70.89 cM
Mapping Data

3 experiments

SNPs within 2kb

509 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932395	protein coding gene	Chr2:143789315-143853216 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026579	protein coding gene	Chr2:147998331-148065046 (-)
A/J	MGP_AJ_G0026543	protein coding gene	Chr2:142021696-142084662 (-)
AKR/J	MGP_AKRJ_G0026517	protein coding gene	Chr2:146097739-146165810 (-)
BALB/cJ	MGP_BALBcJ_G0026555	protein coding gene	Chr2:142469210-142532729 (-)
C3H/HeJ	MGP_C3HHeJ_G0026298	protein coding gene	Chr2:146642810-146706340 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027000	protein coding gene	Chr2:152459842-152529774 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024377	protein coding gene	Chr2:136213440-136276667 (-)
CAST/EiJ	MGP_CASTEiJ_G0025759	protein coding gene	Chr2:146948038-147033461 (-)
CBA/J	MGP_CBAJ_G0026278	protein coding gene	Chr2:158007692-158073666 (-)
DBA/2J	MGP_DBA2J_G0026412	protein coding gene	Chr2:141314269-141377488 (-)
FVB/NJ	MGP_FVBNJ_G0026376	protein coding gene	Chr2:139901509-139964731 (-)
LP/J	MGP_LPJ_G0026516	protein coding gene	Chr2:148172370-148238817 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026396	protein coding gene	Chr2:162233792-162301793 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027055	protein coding gene	Chr2:146101248-146166458 (-)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0025296	protein coding gene	Chr2:145125521-145207468 (-)
WSB/EiJ	MGP_WSBEiJ_G0025832	protein coding gene	Chr2:147112031-147176104 (-)

Human Ortholog

RRBP1, ribosome binding protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RRBP1, ribosome binding protein 1
Synonyms

ES130, ES/130, hES, p180, RRp
Links

HGNC:10448

NCBI Gene ID: 6238

neXtProt AC: NX_Q9P2E9

UniProt: Q9P2E9
Chr Location

20p12.1; chr20:17613678-17682283 (-) GRCh38.p7

Alliance of Genome Resources

Rrbp1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RRBP1
Gene Tree

Rrbp1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

23
Radiation induced

1
Genomic Mutations

2 involving Rrbp1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

690
Tissues

17
cDNA Data

15
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rrbp1

ZFIN rrbp1a, rrbp1b

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Rrbp1 interacts with 138 markers (Mir1a-1, Mir1a-2, Mir9-1, ...) View All

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All Sequences

78
RefSeq

14
UniProt

5
CCDS

CCDS38252.1, CCDS38253.1

Ensembl

ENSMUSG00000027422 (Evidence)
NCBI Gene

81910

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027422	Ensembl Gene Model \| MGI Sequence Detail	63869	C57BL/6J	± kb
transcript	ENSMUST00000016072	Ensembl \| MGI Sequence Detail	5177	Not Applicable
polypeptide	ENSMUSP00000016072	Ensembl \| MGI Sequence Detail	1464	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014303 ribosome-binding protein 1

(term hierarchy)
InterPro Domains

IPR040248 Ribosome-binding protein 1

IPR007794 Ribosome receptor lysine/proline rich

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All nucleic 18

cDNA 16

Primer pair 2

Microarray probesets 6

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MGI:1920757, MGI:1926071

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 9
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:193640 Lo JC, et al., RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet. 2012;8(10):e1002969

TSS for Rrbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26586	Chr2:143853122-143853156 (-)	44 bp
Tssr26585	Chr2:143853092-143853117 (-)	78 bp
Tssr26584	Chr2:143852730-143852803 (-)	416 bp
Tssr26583	Chr2:143851122-143851138 (-)	2,053 bp
Tssr26582	Chr2:143832097-143832141 (-)	21,064 bp
Tssr26581	Chr2:143832039-143832070 (-)	21,128 bp
Tssr26580	Chr2:143831799-143831823 (-)	21,372 bp
Tssr26579	Chr2:143831592-143831613 (-)	21,580 bp
Tssr26578	Chr2:143831254-143831264 (-)	21,924 bp
Tssr26577	Chr2:143831014-143831028 (-)	22,162 bp
Tssr26576	Chr2:143830981-143830997 (-)	22,194 bp
Tssr26575	Chr2:143830922-143830937 (-)	22,253 bp
Tssr26574	Chr2:143830894-143830905 (-)	22,283 bp
Tssr26573	Chr2:143830372-143830395 (-)	22,799 bp
Tssr26572	Chr2:143825084-143825092 (-)	28,095 bp
Tssr26571	Chr2:143794185-143794201 (-)	58,990 bp
Tssr26570	Chr2:143790347-143790364 (-)	62,827 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/05/2021 MGI 6.17