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Ift122 Gene Detail
Summary
  • Symbol
    Ift122
  • Name
    intraflagellar transport 122
  • Synonyms
    C86139, sopb, Wdr10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932386
    NCBI Gene: 81896
Location & Maps
more
  • Sequence Map
    Chr6:115853470-115926699 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      73230 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IFT122, intraflagellar transport 122
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IFT122, intraflagellar transport 122
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CED, CED1, SPG, WDR10, WDR10p, WDR140
  • Links
    NCBI Gene ID: 55764
    neXtProt AC: NX_Q9HBG6

  • Chr Location
    3q21; chr3:129440036-129520507 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IFT122 associations

Human Disease Mouse Models
       Cranioectodermal Dysplasia 1; CED1   OMIM: 218330
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 3 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    1
  • Gene trapped
    6
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Ift122
  • Incidental Mutations
Homozygotes for a null mutation display embryonic lethality during organogenesis with exencephaly, a ventralized caudal neural tube, preaxial polydactyly, abnormal cilia, and left-right patterning defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023171 VEGA Gene Model | MGI Sequence Detail 73230 C57BL/6J ±  kb
transcript OTTMUST00000139896 VEGA | MGI Sequence Detail 3765 Not Applicable  
polypeptide OTTMUSP00000073384 VEGA | MGI Sequence Detail 1241 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    403 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000008931 intraflagellar transport protein 122
  • InterPro Domains
    IPR011990 Tetratricopeptide-like helical domain
    IPR001680 WD40 repeat
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
    IPR013083 Zinc finger, RING/FYVE/PHD-type
Molecular
Reagents
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  • All nucleic 54
    cDNA 54

    Microarray probesets 4
Other
Accession IDs
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MGI:2141776, MGI:3578193
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 13
    Phenotypes 15
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:217609 Goggolidou P, et al., ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis. Development. 2014 Oct;141(20):3966-77

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory