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Ift122
Gene Detail
 Symbol
Name
ID
Ift122
intraflagellar transport 122
MGI:1932386
Synonyms C86139, sopb, Wdr10
Feature Type protein coding gene
Genetic Map
Chromosome 6
53.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:115853470-115926699 bp, + strand
From VEGA annotation of GRCm38

  73230 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12819  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ift122

Human
homologs
Human Homolog IFT122, intraflagellar transport 122
NCBI Gene ID 55764
neXtProt AC  NX_Q9HBG6
Human Synonyms  CED, CED1, SPG, WDR10, WDR10p, WDR140
Human Chr (Location)  3q21; chr3:129440036-129520507 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human IFT122
Alleles
and
phenotypes
All alleles(10) : Chemically induced (ENU)(1) Gene trapped(6) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null mutation display embryonic lethality during organogenesis with exencephaly, a ventralized caudal neural tube, preaxial polydactyly, abnormal cilia, and left-right patterning defects.
 
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process camera-type eye morphogenesis, cell projection organization, ...
Component cell, cell projection, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (72)    Tissues (7)    Images (20)
Theiler Stages: 23
Assay TypeResults
RNA in situ 72
cDNA source data(54)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(54) cDNA(54)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023171 (Evidence)
Ensembl Gene ModelENSMUSG00000030323 (Evidence)
Entrez Gene81896 (Evidence)
UniGene333335
DFCITC1574702, TC1595605, TC1598339, TC1605735
NIA Mouse Gene IndexU007300
Consensus CDS ProjectCCDS20445.1, CCDS51880.1
International Mouse Knockout Project StatusIft122
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023171 VEGA Gene Model | MGI Sequence Detail 73230 C57BL/6J ±  kb
transcript OTTMUST00000056043 VEGA | MGI Sequence Detail 3965 Not Applicable 
polypeptide OTTMUSP00000026893 VEGA | MGI Sequence Detail 1242 Not Applicable 

For the selected sequences
All sequences(116) RefSeq(10) UniProt(5)
Polymorphisms SNPs within 2kb(453 from dbSNP Build 137)    SNPs within 2kb including multiple locations(499)
Protein-related
information
ResourceIDDescription
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR001680 WD40 repeat
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000008931 intraflagellar transport protein 122
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:196508 Bay SN, et al., What are those cilia doing in the neural tube?. Cilia. 2012;1(1):19
All references(43)
Other
accession IDs
MGI:2141776, MGI:3578193

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory