Cacng8 MGI Mouse Gene Detail - MGI:1932376 - calcium channel, voltage-dependent, gamma subunit 8

Symbol

Cacng8
Name

calcium channel, voltage-dependent, gamma subunit 8
Synonyms

TARP gamma 8

Feature Type

protein coding gene
IDs

MGI:1932376
NCBI Gene: 81905
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:3394042-3415605 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 1.98 cM
Mapping Data

1 experiment

SNPs within 2kb

180 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932376	protein coding gene	Chr7:3390683-3415648 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0031518	protein coding gene	Chr7:308775-335251 (+)
A/J	MGP_AJ_G0031493	protein coding gene	Chr7:299265-325521 (+)
AKR/J	MGP_AKRJ_G0031421	protein coding gene	Chr7:295174-320154 (+)
BALB/cJ	MGP_BALBcJ_G0031501	protein coding gene	Chr7:300609-326429 (+)
C3H/HeJ	MGP_C3HHeJ_G0031221	protein coding gene	Chr7:304953-331498 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031961	protein coding gene	Chr7:307668-340295 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029088	protein coding gene	Chr7:195838-221336 (+)
CAST/EiJ	MGP_CASTEiJ_G0030590	protein coding gene	Chr7:301728-329298 (+)
CBA/J	MGP_CBAJ_G0031181	protein coding gene	Chr7:408165-441897 (+)
DBA/2J	MGP_DBA2J_G0031338	protein coding gene	Chr7:291948-316965 (+)
FVB/NJ	MGP_FVBNJ_G0031290	protein coding gene	Chr7:287754-313907 (+)
LP/J	MGP_LPJ_G0031423	protein coding gene	Chr7:305755-334783 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031329	protein coding gene	Chr7:338093-366324 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031995	protein coding gene	Chr7:287332-314177 (+)
PWK/PhJ	MGP_PWKPhJ_G0030317	protein coding gene	Chr7:434286-460275 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030141	protein coding gene	Chr7:367363-391824 (+)
WSB/EiJ	MGP_WSBEiJ_G0030684	protein coding gene	Chr7:296395-325223 (+)

Human Ortholog

CACNG8, calcium voltage-gated channel auxiliary subunit gamma 8

Vertebrate Orthologs

7

Human Ortholog

CACNG8, calcium voltage-gated channel auxiliary subunit gamma 8
Orthology source: HomoloGene, HGNC
Links

HGNC:13628

NCBI Gene ID: 59283

neXtProt AC: NX_Q8WXS5

UniProt: Q8WXS5
Chr Location

19q13.42; chr19:53963036-53990215 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 12894
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: CACNG8
Gene Tree

Cacng8

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Phenotype Summary

10 phenotypes from 3 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Gene trapped

22
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Targeted null mutations of this gene result in altered hippocampal AMPA receptor number, distribution and synaptic plasticity. Mice homozygous for one knock-out allele exhibit significantly impaired long term potentiation in hippocampal CA1 synapses.

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All GO Annotations

53
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

61
Tissues

30
cDNA Data

4
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cacng8

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All Sequences

35
RefSeq

2
UniProt

3
CCDS

CCDS57471.1
UniGene

357990

Ensembl

ENSMUSG00000053395 (Evidence)
NCBI Gene

81905 (Evidence)

			Length	Strain/Species	Flank
genomic	81905	NCBI Gene Model \| MGI Sequence Detail	21564	C57BL/6J	± kb
transcript	NM_133190	RefSeq \| MGI Sequence Detail	1455	C57BL/6
polypeptide	Q8VHW2	UniProt \| EBI \| MGI Sequence Detail	423	Not Applicable

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UniProt

3 Sequences
InterPro Domains

IPR004031 PMP-22/EMP/MP20/Claudin superfamily

IPR008372 Voltage-dependent calcium channel, gamma-8 subunit

IPR008368 Voltage-dependent calcium channel, gamma subunit

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All nucleic 5

Genomic 1

cDNA 4

Microarray probesets 2

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 13
Earliest

J:67725 Burgess DL, et al., A Cluster of Three Novel Ca(2+) Channel gamma Subunit Genes on Chromosome 19q13.4: Evolution and Expression Profile of the gamma Subunit Gene Family. Genomics. 2001 Feb 1;71(3):339-50
Latest

J:261481 Sheng N, et al., LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3948-3953

TSS for Cacng8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64261	Chr7:3390181-3390231 (+)	-3,836 bp
Tssr64262	Chr7:3390316-3390337 (+)	-3,715 bp
Tssr64263	Chr7:3390469-3390479 (+)	-3,568 bp
Tssr64264	Chr7:3390629-3390707 (+)	-3,374 bp
Tssr64265	Chr7:3390785-3390861 (+)	-3,219 bp
Tssr64266	Chr7:3390879-3390899 (+)	-3,153 bp
Tssr64267	Chr7:3390909-3390920 (+)	-3,127 bp
Tssr64268	Chr7:3391019-3391040 (+)	-3,012 bp
Tssr64269	Chr7:3391098-3391115 (+)	-2,935 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/06/2018 MGI 6.13