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Cacng8
Gene Detail
 Symbol
Name
ID
Cacng8
calcium channel, voltage-dependent, gamma subunit 8
MGI:1932376
Synonyms TARP gamma 8
Feature Type protein coding gene
Genetic Map
Chromosome 7
1.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:3390683-3415648 bp, + strand
From VEGA annotation of GRCm38

  24966 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12894  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Cacng8

Human
homologs
Human Homolog CACNG8, calcium channel, voltage-dependent, gamma subunit 8
NCBI Gene ID 59283
neXtProt AC  NX_Q8WXS5
Human Chr (Location)  19q13.4; chr19:53963036-53990215 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(30) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted null mutations of this gene result in altered hippocampal AMPA receptor number, distribution and synaptic plasticity. Mice homozygous for one knock-out allele exhibit significantly impaired long term potentiation in hippocampal CA1 synapses.
 
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex, cell junction, ...
Function calcium channel activity, voltage-gated ion channel activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (61)    Tissues (30)    Images (32)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 61
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) Genomic(1) cDNA(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000044343 (Evidence)
Ensembl Gene ModelENSMUSG00000053395 (Evidence)
Entrez Gene81905 (Evidence)
UniGene357990
DFCITC1692020
DoTSDT.91384268
NIA Mouse Gene IndexU041273
Consensus CDS ProjectCCDS57471.1
International Mouse Knockout Project StatusCacng8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044343 VEGA Gene Model | MGI Sequence Detail 24966 C57BL/6J ±  kb
transcript OTTMUST00000116707 VEGA | MGI Sequence Detail 1897 Not Applicable 
polypeptide OTTMUSP00000065084 VEGA | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(189 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004031 PMP-22/EMP/MP20/Claudin
InterPro IPR008372 Voltage-dependent calcium channel, gamma-8 subunit
InterPro IPR008368 Voltage-dependent calcium channel, gamma subunit
Protein Ontology PR:000004957 voltage-dependent calcium channel gamma-8 subunit
References (Earliest) J:67725 Burgess DL, et al., A Cluster of Three Novel Ca(2+) Channel gamma Subunit Genes on Chromosome 19q13.4: Evolution and Expression Profile of the gamma Subunit Gene Family. Genomics. 2001 Feb 1;71(3):339-50
(Latest) J:197912 Herring BE, et al., Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Neuron. 2013 Mar 20;77(6):1083-96
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory