Cacng8 MGI Mouse Gene Detail - MGI:1932376 - calcium channel, voltage-dependent, gamma subunit 8

Cacng8 Gene Detail

Symbol

Cacng8
Name

calcium channel, voltage-dependent, gamma subunit 8
Synonyms

TARP gamma 8

Feature Type

protein coding gene
IDs

MGI:1932376
NCBI Gene: 81905

Sequence Map

Chr7:3390683-3415648 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

24966 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 1.98 cM
Mapping Data

1 experiment

Human Ortholog

CACNG8, calcium voltage-gated channel auxiliary subunit gamma 8

Vertebrate Orthologs

7

Human Ortholog

CACNG8, calcium voltage-gated channel auxiliary subunit gamma 8
Orthology source: HomoloGene, HGNC
Links

HGNC:13628

NCBI Gene ID: 59283

neXtProt AC: NX_Q8WXS5

UniProt: Q8WXS5
Chr Location

19q13.42; chr19:53963036-53990215 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 12894
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: CACNG8
Gene Tree

Cacng8

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Phenotype Summary

10 phenotypes from 3 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Gene trapped

30
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

Targeted null mutations of this gene result in altered hippocampal AMPA receptor number, distribution and synaptic plasticity. Mice homozygous for one knock-out allele exhibit significantly impaired long term potentiation in hippocampal CA1 synapses.

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All GO Annotations

25
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

61
Tissues

30
cDNA Data

3
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cacng8

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All Sequences

22
RefSeq

2
UniProt

3
CCDS

CCDS57471.1
UniGene

357990

			Length	Strain/Species	Flank
genomic	OTTMUSG00000044343	VEGA Gene Model \| MGI Sequence Detail	24966	C57BL/6J	± kb
transcript	OTTMUST00000116707	VEGA \| MGI Sequence Detail	1897	Not Applicable
polypeptide	OTTMUSP00000065084	VEGA \| MGI Sequence Detail	423	Not Applicable

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SNPs within 2kb

189 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000004957 voltage-dependent calcium channel gamma-8 subunit

(term hierarchy)
InterPro Domains

IPR004031 PMP-22/EMP/MP20/Claudin superfamily

IPR008372 Voltage-dependent calcium channel, gamma-8 subunit

IPR008368 Voltage-dependent calcium channel, gamma subunit

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All nucleic 4

Genomic 1

cDNA 3

Microarray probesets 2

Summaries

All 35

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 13
Earliest

J:67725 Burgess DL, et al., A Cluster of Three Novel Ca(2+) Channel gamma Subunit Genes on Chromosome 19q13.4: Evolution and Expression Profile of the gamma Subunit Gene Family. Genomics. 2001 Feb 1;71(3):339-50
Latest

J:240979 Kato AS, et al., Forebrain-selective AMPA-receptor antagonism guided by TARP gamma-8 as an antiepileptic mechanism. Nat Med. 2016 Dec;22(12):1496-1501

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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