Cacng8
Gene Detail

Symbol

Name
ID

Cacng8
calcium channel, voltage-dependent, gamma subunit 8
MGI:1932376

Synonyms

TARP gamma 8

Feature Type

protein coding gene

Genetic Map

Chromosome 7
1.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:3390683-3415648 bp, + strand From VEGA annotation of GRCm38   24966 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:12894  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Cacng8

Human
homologs

Human Homolog		CACNG8, calcium channel, voltage-dependent, gamma subunit 8
NCBI Gene ID		59283
neXtProt AC		NX_Q8WXS5
Human Chr (Location)		19q13.4; chr19:53963036-53990215 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(34) : Gene trapped(30) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Targeted null mutations of this gene result in altered hippocampal AMPA receptor number, distribution and synaptic plasticity. Mice homozygous for one knock-out allele exhibit significantly impaired long term potentiation in hippocampal CA1 synapses.

 

Gene Ontology
(GO)
classifications

All GO classifications: (21 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex, cell junction, ...
Function	calcium channel activity, voltage-gated ion channel activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (61)    Tissues (30)    Images (32)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	61

cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(4) Genomic(1) cDNA(3)
Microarray probesets(2)

Other database
links

VEGA Gene Model	OTTMUSG00000044343 (Evidence)
Ensembl Gene Model	ENSMUSG00000053395 (Evidence)
Entrez Gene	81905 (Evidence)
UniGene	357990
DFCI	TC1692020
DoTS	DT.91384268
NIA Mouse Gene Index	U041273
Consensus CDS Project	CCDS57471.1
International Mouse Knockout Project Status	Cacng8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000044343	VEGA Gene Model | MGI Sequence Detail	24966	C57BL/6J
transcript	OTTMUST00000116707	VEGA | MGI Sequence Detail	1897	Not Applicable
polypeptide	OTTMUSP00000065084	VEGA | MGI Sequence Detail	423	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

SNPs within 2kb(189 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR004031	PMP-22/EMP/MP20/Claudin
InterPro	IPR008372	Voltage-dependent calcium channel, gamma-8 subunit
InterPro	IPR008368	Voltage-dependent calcium channel, gamma subunit
Protein Ontology	PR:000004957	voltage-dependent calcium channel gamma-8 subunit

References

(Earliest) J:67725 Burgess DL, et al., A Cluster of Three Novel Ca(2+) Channel gamma Subunit Genes on Chromosome 19q13.4: Evolution and Expression Profile of the gamma Subunit Gene Family. Genomics. 2001 Feb 1;71(3):339-50
(Latest) J:197912 Herring BE, et al., Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Neuron. 2013 Mar 20;77(6):1083-96
All references(36)