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Cacng8 Gene Detail
Summary
  • Symbol
    Cacng8
  • Name
    calcium channel, voltage-dependent, gamma subunit 8
  • Synonyms
    TARP gamma 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932376
    NCBI Gene: 81905
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:3442558-3464782 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 1.98 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932376
 protein coding gene Chr7:3439199-3464782 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031518
 protein coding gene Chr7:308775-335251 (+)
A/J MGP_AJ_G0031493
 protein coding gene Chr7:299265-325521 (+)
AKR/J MGP_AKRJ_G0031421
 protein coding gene Chr7:295174-320154 (+)
BALB/cJ MGP_BALBcJ_G0031501
 protein coding gene Chr7:300609-326429 (+)
C3H/HeJ MGP_C3HHeJ_G0031221
 protein coding gene Chr7:304953-331498 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031961
 protein coding gene Chr7:307668-340295 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029088
 protein coding gene Chr7:195838-221336 (+)
CAST/EiJ MGP_CASTEiJ_G0030590
 protein coding gene Chr7:301728-329298 (+)
CBA/J MGP_CBAJ_G0031181
 protein coding gene Chr7:408165-441897 (+)
DBA/2J MGP_DBA2J_G0031338
 protein coding gene Chr7:291948-316965 (+)
FVB/NJ MGP_FVBNJ_G0031290
 protein coding gene Chr7:287754-313907 (+)
LP/J MGP_LPJ_G0031423
 protein coding gene Chr7:305755-334783 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031329
 protein coding gene Chr7:338093-366324 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031995
 protein coding gene Chr7:287332-314177 (+)
PWK/PhJ MGP_PWKPhJ_G0030317
 protein coding gene Chr7:434286-460275 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030141
 protein coding gene Chr7:367363-391824 (+)
WSB/EiJ MGP_WSBEiJ_G0030684
 protein coding gene Chr7:296395-325223 (+)



Homology
more
  • Human Ortholog
    CACNG8, calcium voltage-gated channel auxiliary subunit gamma 8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CACNG8, calcium voltage-gated channel auxiliary subunit gamma 8
  • Links
    NCBI Gene ID: 59283
    UniProt: Q8WXS5

  • Chr Location
    19q13.42; chr19:53962937-53990215 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cacng8 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted null mutations of this gene result in altered hippocampal AMPA receptor number, distribution and synaptic plasticity. Mice homozygous for one knock-out allele exhibit significantly impaired long term potentiation in hippocampal CA1 synapses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    30
  • cDNA Data
    4
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 81905 NCBI Gene Model | MGI Sequence Detail 22225 C57BL/6J ±  kb
    transcript NM_133190 RefSeq | MGI Sequence Detail 2376 C57BL/6  
    polypeptide Q8VHW2 UniProt | EBI | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000004957 voltage-dependent calcium channel gamma-8 subunit
      (term hierarchy)
    • PDB
      7LDD, 7LDE, 7LEP
    • InterPro Domains
      IPR004031 PMP-22/EMP/MP20/Claudin
      IPR008372 Voltage-dependent calcium channel, gamma-8 subunit
      IPR051072 Voltage-dependent calcium channel gamma subunit
      IPR008368 Voltage-dependent calcium channel, gamma subunit
    • GlyGen
      Q8VHW2 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 5
      Genomic 1
      cDNA 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 15
      Phenotypes 17
    • Earliest
      J:67725 Burgess DL, et al., A Cluster of Three Novel Ca(2+) Channel gamma Subunit Genes on Chromosome 19q13.4: Evolution and Expression Profile of the gamma Subunit Gene Family. Genomics. 2001 Feb 1;71(3):339-50
    • Latest
      J:336525 van der Spek SJF, et al., Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition. Cells. 2022 Nov 17;11(22)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory