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Cacng8 Gene Detail
Summary
  • Symbol
    Cacng8
  • Name
    calcium channel, voltage-dependent, gamma subunit 8
  • Synonyms
    TARP gamma 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932376
    NCBI Gene: 81905
  • Alliance
    gene page
Location & Maps
more
  • Genetic Map
    Chromosome 7, 1.98 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CACNG8, calcium voltage-gated channel auxiliary subunit gamma 8
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CACNG8, calcium voltage-gated channel auxiliary subunit gamma 8
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 59283
    neXtProt AC: NX_Q8WXS5
    UniProt: Q8WXS5

  • Chr Location
    19q13.42; chr19:53963036-53990215 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted null mutations of this gene result in altered hippocampal AMPA receptor number, distribution and synaptic plasticity. Mice homozygous for one knock-out allele exhibit significantly impaired long term potentiation in hippocampal CA1 synapses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    53
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    61
  • Tissues
    30
  • cDNA Data
    4
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000044343 VEGA Gene Model | MGI Sequence Detail 24966 C57BL/6J ±  kb
    transcript OTTMUST00000116707 VEGA | MGI Sequence Detail 1897 Not Applicable  
    polypeptide OTTMUSP00000065084 VEGA | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      189 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR004031 PMP-22/EMP/MP20/Claudin superfamily
      IPR008372 Voltage-dependent calcium channel, gamma-8 subunit
      IPR008368 Voltage-dependent calcium channel, gamma subunit
    Molecular
    Reagents
    less
    • All nucleic 5
      Genomic 1
      cDNA 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:67725 Burgess DL, et al., A Cluster of Three Novel Ca(2+) Channel gamma Subunit Genes on Chromosome 19q13.4: Evolution and Expression Profile of the gamma Subunit Gene Family. Genomics. 2001 Feb 1;71(3):339-50
    • Latest
      J:253355 Park J, et al., CaMKII Phosphorylation of TARPgamma-8 Is a Mediator of LTP and Learning and Memory. Neuron. 2016 Oct 5;92(1):75-83
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/16/2018
    MGI 6.12     		The Jackson Laboratory