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Cacng8 Gene Detail
Summary
  • Symbol
    Cacng8
  • Name
    calcium channel, voltage-dependent, gamma subunit 8
  • Synonyms
    TARP gamma 8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932376
    NCBI Gene: 81905
Location & Maps
more
Homology
more
  • Human Ortholog
    CACNG8, calcium channel, voltage-dependent, gamma subunit 8
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CACNG8, calcium channel, voltage-dependent, gamma subunit 8
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 59283
    neXtProt AC: NX_Q8WXS5

  • Chr Location
    19q13.4; chr19:53963036-53990215 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    34
  • Gene trapped
    30
  • Targeted
    4
  • Incidental Mutations
Targeted null mutations of this gene result in altered hippocampal AMPA receptor number, distribution and synaptic plasticity. Mice homozygous for one knock-out allele exhibit significantly impaired long term potentiation in hippocampal CA1 synapses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044343 VEGA Gene Model | MGI Sequence Detail 24966 C57BL/6J ±  kb
transcript OTTMUST00000116707 VEGA | MGI Sequence Detail 1897 Not Applicable  
polypeptide OTTMUSP00000065084 VEGA | MGI Sequence Detail 423 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    189 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000004957 voltage-dependent calcium channel gamma-8 subunit
  • InterPro Domains
    IPR004031 PMP-22/EMP/MP20/Claudin superfamily
    IPR008372 Voltage-dependent calcium channel, gamma-8 subunit
    IPR008368 Voltage-dependent calcium channel, gamma subunit
Molecular
Reagents
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  • All nucleic 4
    Genomic 1
    cDNA 3

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:67725 Burgess DL, et al., A Cluster of Three Novel Ca(2+) Channel gamma Subunit Genes on Chromosome 19q13.4: Evolution and Expression Profile of the gamma Subunit Gene Family. Genomics. 2001 Feb 1;71(3):339-50
  • Latest
    J:197912 Herring BE, et al., Cornichon proteins determine the subunit composition of synaptic AMPA receptors. Neuron. 2013 Mar 20;77(6):1083-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory