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Sorcs2 Gene Detail
Summary
  • Symbol
    Sorcs2
  • Name
    sortilin-related VPS10 domain containing receptor 2
  • Synonyms
    mKIAA1329, VPS10 domain receptor protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932289
    NCBI Gene: 81840
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:36017180-36398139 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 19.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2449 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932289
protein coding gene Chr5:36017180-36398163 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029486
protein coding gene Chr5:34333363-34726970 (-)
A/J MGP_AJ_G0029453
protein coding gene Chr5:33208832-33589548 (-)
AKR/J MGP_AKRJ_G0029402
protein coding gene Chr5:34477114-34857316 (-)
BALB/cJ MGP_BALBcJ_G0029463
protein coding gene Chr5:33719292-34099228 (-)
C3H/HeJ MGP_C3HHeJ_G0029185
protein coding gene Chr5:34488956-34876351 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029917
protein coding gene Chr5:36227146-36620943 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027154
protein coding gene Chr5:30959640-31331637 (-)
CAST/EiJ MGP_CASTEiJ_G0028594
protein coding gene Chr5:33589598-33982768 (-)
CBA/J MGP_CBAJ_G0029153
protein coding gene Chr5:37101439-37512925 (-)
DBA/2J MGP_DBA2J_G0029301
protein coding gene Chr5:33349374-33729002 (-)
FVB/NJ MGP_FVBNJ_G0029260
protein coding gene Chr5:32822136-33207203 (-)
LP/J MGP_LPJ_G0029386
protein coding gene Chr5:34768412-35178890 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029290
protein coding gene Chr5:37871850-38270867 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029950
protein coding gene Chr5:33971314-34359429 (-)
PWK/PhJ MGP_PWKPhJ_G0028319
protein coding gene Chr5:32518497-32900345 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028150
protein coding gene Chr5:33419334-33825580 (-)
WSB/EiJ MGP_WSBEiJ_G0028675
protein coding gene Chr5:34033469-34437684 (-)



Homology
more
  • Human Ortholog
    SORCS2, sortilin related VPS10 domain containing receptor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SORCS2, sortilin related VPS10 domain containing receptor 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 57537
    neXtProt AC: NX_Q96PQ0
    UniProt: Q96PQ0

  • Chr Location
    4p16.1; chr4:7192607-7742837 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to reduced dopamine levels and dopamine metabolism, dopaminergic hyperinnervation of the frontal cortex, hyperactivity, abnormal behavioral response to amphetamine, and decreased induction of Schwann cell apoptosis following sciatic nerve injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029093 Ensembl Gene Model | MGI Sequence Detail 380960 C57BL/6J ±  kb
    transcript ENSMUST00000037370 Ensembl | MGI Sequence Detail 5707 Not Applicable  
    polypeptide ENSMUSP00000041828 Ensembl | MGI Sequence Detail 1159 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 59

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2141349
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 3
      Phenotypes 32
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:262532 Boggild S, et al., Highly segregated localization of the functionally related vps10p receptors sortilin and SorCS2 during neurodevelopment. J Comp Neurol. 2018 Jun 1;526(8):1267-1286

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory