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Sorcs2 Gene Detail
Summary
  • Symbol
    Sorcs2
  • Name
    sortilin-related VPS10 domain containing receptor 2
  • Synonyms
    mKIAA1329, VPS10 domain receptor protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932289
    NCBI Gene: 81840
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:36017180-36398139 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      380960 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 19.14 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SORCS2, sortilin related VPS10 domain containing receptor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SORCS2, sortilin related VPS10 domain containing receptor 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 57537
    neXtProt AC: NX_Q96PQ0
    UniProt: Q96PQ0

  • Chr Location
    4p16.1; chr4:7192607-7742837 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to reduced dopamine levels and dopamine metabolism, dopaminergic hyperinnervation of the frontal cortex, hyperactivity, abnormal behavioral response to amphetamine, and decreased induction of Schwann cell apoptosis following sciatic nerve injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000028018 VEGA Gene Model | MGI Sequence Detail 380960 C57BL/6J ±  kb
    transcript OTTMUST00000069382 VEGA | MGI Sequence Detail 5707 Not Applicable  
    polypeptide OTTMUSP00000035234 VEGA | MGI Sequence Detail 1159 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2449 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 57

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2141349
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 3
      Phenotypes 31
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:244563 Ma Q, et al., SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease. JCI Insight. 2017 May 04;2(9):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory