Egln3
Gene Detail

Symbol Name ID

Egln3 egl-9 family hypoxia-inducible factor 3 MGI:1932288

Synonyms

2610021G09Rik, Hif-p4h-3, Phd3, SM-20

Feature Type

protein coding gene

Genetic Map

Chromosome 12

22.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:54178981-54203860 bp, - strand From VEGA annotation of GRCm38   24880 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32531  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Egln3

Human homologs

Human Homolog		EGLN3, egl-9 family hypoxia-inducible factor 3
NCBI Gene ID		112399
neXtProt AC		NX_Q9H6Z9
Human Synonyms		HIFP4H3, HIFPH3, PHD3
Human Chr (Location)		14q13.1; chr14:33924215-33951078 (-)  GRCh38

Alleles and phenotypes

All alleles(8) : Gene trapped(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mice display decreased apoptosis in SCG neurons, reduced adrenal medullary secretory capacity, abnormal adrenal medulla morphology, reduced circulating adrenaline and noradrenaline levels, and reduced systolic blood pressure.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	apoptotic process, cellular response to DNA damage stimulus, ...
Component	cytoplasm, cytosol, ...
Function	dioxygenase activity, iron ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (17)    Tissues (11)   
Theiler Stages: 11, 13, 15, 17, 20, 22, 24

Assay Type	Results
Immunohistochemistry	17

cDNA source data(106)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(106) cDNA(106)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000034921 (Evidence)
Ensembl Gene Model	ENSMUSG00000035105 (Evidence)
Entrez Gene	112407 (Evidence)
UniGene	133037
DFCI	TC1574967, TC1589921
DoTS	DT.101135364, DT.490642, DT.94197711
NIA Mouse Gene Index	U033945
EC	1.14.11.29
Consensus CDS Project	CCDS25908.1
International Mouse Knockout Project Status	Egln3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034921	VEGA Gene Model | MGI Sequence Detail	24880	C57BL/6J
transcript	OTTMUST00000088785	VEGA | MGI Sequence Detail	2662	Not Applicable
polypeptide	OTTMUSP00000048435	VEGA | MGI Sequence Detail	239	Not Applicable

All sequences(31) RefSeq(2) UniProt(1)

Polymorphisms

SNPs within 2kb(128 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR005123	Oxoglutarate/iron-dependent dioxygenase
InterPro	IPR006620	Prolyl 4-hydroxylase, alpha subunit
Protein Ontology	PR:000006936	egl nine homolog 3

References

(Earliest) J:60099 Moschella MC, et al., SM-20 is a novel growth factor-responsive gene regulated during skeletal muscle development and differentiation. Gene Expr. 1999;8(1):59-66
(Latest) J:208042 Duan LJ, et al., Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver. Am J Pathol. 2014 Apr;184(4):1240-50
All references(61)

Other accession IDs

MGI:1919408, MGI:2144852, MGI:2144873