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Egln3
Gene Detail
Symbol

Name
ID
Egln3
egl-9 family hypoxia-inducible factor 3
MGI:1932288
Synonyms
2610021G09Rik, Hif-p4h-3, Phd3, SM-20
Feature Type
protein coding gene
Genetic Map
Chromosome 12
22.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:54178981-54203860 bp, - strand
From VEGA annotation of GRCm38

  24880 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32531  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Egln3

Human
homologs
Human Homolog EGLN3, egl-9 family hypoxia-inducible factor 3
NCBI Gene ID 112399
neXtProt AC  NX_Q9H6Z9
Human Synonyms  HIFP4H3, HIFPH3, PHD3
Human Chr (Location)  14q13.1; chr14:33924215-33951078 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display decreased apoptosis in SCG neurons, reduced adrenal medullary secretory capacity, abnormal adrenal medulla morphology, reduced circulating adrenaline and noradrenaline levels, and reduced systolic blood pressure.
 
Interactions
Egln3 interacts with 228 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process apoptotic process, cellular response to DNA damage stimulus, ...
Component cytoplasm, cytosol, ...
Function dioxygenase activity, iron ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (17)    Tissues (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
cDNA source data(106)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(106) cDNA(106)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000034921 (Evidence)
Ensembl Gene ModelENSMUSG00000035105 (Evidence)
Entrez Gene112407 (Evidence)
UniGene133037
DFCITC1574967, TC1589921
DoTSDT.101135364, DT.490642, DT.94197711
NIA Mouse Gene IndexU033945
EC1.14.11.29
Consensus CDS ProjectCCDS25908.1
International Mouse Knockout Project StatusEgln3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034921 VEGA Gene Model | MGI Sequence Detail 24880 C57BL/6J ±  kb
transcript OTTMUST00000088785 VEGA | MGI Sequence Detail 2662 Not Applicable 
polypeptide OTTMUSP00000048435 VEGA | MGI Sequence Detail 239 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(128 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005123 Oxoglutarate/iron-dependent dioxygenase
InterPro IPR006620 Prolyl 4-hydroxylase, alpha subunit
Protein Ontology PR:000006936 egl nine homolog 3
References
(Earliest) J:60099 Moschella MC, et al., SM-20 is a novel growth factor-responsive gene regulated during skeletal muscle development and differentiation. Gene Expr. 1999;8(1):59-66
(Latest) J:208042 Duan LJ, et al., Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver. Am J Pathol. 2014 Apr;184(4):1240-50
All references(64)
Other
accession IDs
MGI:1919408, MGI:2144852, MGI:2144873

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory