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Tnxb Gene Detail
Summary
  • Symbol
    Tnxb
  • Name
    tenascin XB
  • Synonyms
    TN-MHC, Tnx
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932137
    NCBI Gene: 81877
  • Gene Overview
    MyGene.info: TNXB
Location & Maps
more
  • Sequence Map
    Chr17:34670535-34719815 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49281 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TNXB, tenascin XB
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TNXB, tenascin XB
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EDS3, HXBL, TENX, TNX, TN-X, TNXB1, TNXB2, TNXBS, VUR8, XB, XBS
  • Links
    NCBI Gene ID: 7148
    neXtProt AC: NX_P22105

  • Chr Location
    6p21.3; chr6:32041155-32109374 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Tnxb mouse models; 2 with human TNXB associations

Human Disease Mouse Models
       Ehlers-Danlos Syndrome Due to Tenascin-X Deficiency   OMIM: 606408 View 1 model
       Vesicoureteral Reflux 8; VUR8   OMIM: 615963
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous null mice have stretchy skin, similar to patients with human Ehlers-Danlos syndrome.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037253 VEGA Gene Model | MGI Sequence Detail 49281 C57BL/6J ±  kb
transcript OTTMUST00000096074 VEGA | MGI Sequence Detail 12209 Not Applicable  
polypeptide OTTMUSP00000053640 VEGA | MGI Sequence Detail 4006 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR013111 EGF-like domain, extracellular
    IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
    IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
    IPR020837 Fibrinogen, conserved site
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR033081 Tenascin-X
Molecular
Reagents
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  • All nucleic 25
    Genomic 1
    cDNA 22
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-18691, MGI:101866
References
more
  • Summaries
    All 54
    Developmental Gene Expression 8
    Diseases 2
    Gene Ontology 12
    Phenotypes 13
  • Earliest
    J:36890 Saga Y, et al., Mice develop normally without tenascin. Genes Dev. 1992 Oct;6(10):1821-31
  • Latest
    J:215800 Alcaraz LB, et al., Tenascin-X promotes epithelial-to-mesenchymal transition by activating latent TGF-beta. J Cell Biol. 2014 May 12;205(3):409-28

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory