About   Help   FAQ
Tnxb
Gene Detail
 Symbol
Name
ID
Tnxb
tenascin XB
MGI:1932137
Synonyms TN-MHC, Tnx
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:34670535-34719815 bp, + strand
From VEGA annotation of GRCm38

  49281 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49589  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Tnxb

Human
homologs
Human Homolog TNXB, tenascin XB
NCBI Gene ID 7148
neXtProt AC  NX_P22105
Human Synonyms  EDS3, HXBL, TENX, TNX, TN-X, TNXB1, TNXB2, TNXBS, XB, XBS
Human Chr (Location)  6p21.3; chr6:32041155-32109374 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human TNXB
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have stretchy skin, similar to patients with human Ehlers-Danlos syndrome.
 
Human Diseases Modeled Using Mouse Tnxb (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Tnxb interacts with 115 markers (Mir17, Mir20b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cell-matrix adhesion, collagen fibril organization, ...
Component extracellular matrix, extracellular region, ...
Function collagen binding, heparin binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (30)    Tissues (18)    Images (3)
Theiler Stages: 16, 17, 23, 28
Assay TypeResults
RNA in situ 14
Northern blot 16
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(22) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037253 (Evidence)
Ensembl Gene ModelENSMUSG00000033327 (Evidence)
Entrez Gene81877 (Evidence)
UniGene290527
DFCITC1597629, TC1774436
DoTSDT.102558962, DT.525221
NIA Mouse Gene IndexU017866
Consensus CDS ProjectCCDS28656.2
International Mouse Knockout Project StatusTnxb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037253 VEGA Gene Model | MGI Sequence Detail 49281 C57BL/6J ±  kb
transcript OTTMUST00000096074 VEGA | MGI Sequence Detail 12209 Not Applicable 
polypeptide OTTMUSP00000053640 VEGA | MGI Sequence Detail 4006 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(42) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(476 from dbSNP Build 137)    SNPs within 2kb including multiple locations(632)
Protein-related
information
ResourceIDDescription
InterPro IPR013111 EGF, extracellular
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000016524 tenascin-X
References (Earliest) J:36890 Saga Y, et al., Mice develop normally without tenascin. Genes Dev. 1992 Oct;6(10):1821-31
(Latest) J:189446 Bonod-Bidaud C, et al., In vivo evidence for a bridging role of a collagen V subtype at the epidermis-dermis interface. J Invest Dermatol. 2012 Jul;132(7):1841-9
All references(56)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-18691, MGI:101866

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory