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Tnxb Gene Detail
Summary
  • Symbol
    Tnxb
  • Name
    tenascin XB
  • Synonyms
    TN-MHC, Tnx
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932137
    NCBI Gene: 81877
  • Gene Overview
    MyGene.info: TNXB
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr17:34670535-34719815 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    13
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932137
protein coding gene Chr17:34660401-34719815 (.)
129S1/SvImJ no annotation
A/J MGP_AJ_G0023549
protein coding gene Chr17:33558724-33593775 (+)
AKR/J MGP_AKRJ_G0023514
protein coding gene Chr17:33971507-34070969 (+)
BALB/cJ MGP_BALBcJ_G0023553
protein coding gene Chr17:33713620-33772194 (+)
C3H/HeJ MGP_C3HHeJ_G0023313
protein coding gene Chr17:34372318-34456882 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023993
protein coding gene Chr17:36081758-36233660 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021472
protein coding gene Chr17:31448006-31517888 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0023291
protein coding gene Chr17:37588924-37653805 (+)
DBA/2J MGP_DBA2J_G0023419
protein coding gene Chr17:32842871-32929679 (+)
FVB/NJ MGP_FVBNJ_G0023386
protein coding gene Chr17:32768899-32825091 (+)
LP/J MGP_LPJ_G0023497
protein coding gene Chr17:35014423-35088412 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023409
protein coding gene Chr17:36486978-36517776 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024036
protein coding gene Chr17:34303690-34358667 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TNXB, tenascin XB
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TNXB, tenascin XB
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EDS3, EDSCLL, EDSCLL1, HXBL, TENX, TNX, TN-X, TNXB1, TNXB2, TNXBS, VUR8, XB, XBS
  • Links
    NCBI Gene ID: 7148
    neXtProt AC: NX_P22105
    UniProt: P22105

  • Chr Location
    6p21.33-p21.32; chr6:32041155-32109374 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TNXB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice have stretchy skin, similar to patients with human Ehlers-Danlos syndrome.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033327 Ensembl Gene Model | MGI Sequence Detail 49281 C57BL/6J ±  kb
    transcript ENSMUST00000087399 Ensembl | MGI Sequence Detail 12209 Not Applicable  
    polypeptide ENSMUSP00000084661 Ensembl | MGI Sequence Detail 4006 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 23
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18691, MGI:101866
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 9
      Gene Ontology 13
      Phenotypes 16
    • Earliest
      J:36890 Saga Y, et al., Mice develop normally without tenascin. Genes Dev. 1992 Oct;6(10):1821-31
    • Latest
      J:260894 Hashimoto K, et al., Wound healing-related properties detected in an experimental model with a collagen gel contraction assay are affected in the absence of tenascin-X. Exp Cell Res. 2018 Feb 1;363(1):102-113

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory