Tnxb
Gene Detail

Symbol Name ID

Tnxb tenascin XB MGI:1932137

Synonyms

TN-MHC, Tnx

Feature Type

protein coding gene

Genetic Map

Chromosome 17

18.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:34670535-34719815 bp, + strand From VEGA annotation of GRCm38   49281 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49589  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Tnxb

Human homologs

Human Homolog		TNXB, tenascin XB
NCBI Gene ID		7148
neXtProt AC		NX_P22105
Human Synonyms		EDS3, HXBL, TENX, TNX, TN-X, TNXB1, TNXB2, TNXBS, XB, XBS
Human Chr (Location)		6p21.3; chr6:32008932-32077151 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human TNXB

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous null mice have stretchy skin, similar to patients with human Ehlers-Danlos syndrome.

 
Human Diseases Modeled Using Mouse Tnxb (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	cell-cell adhesion, cell-matrix adhesion, ...
Component	extracellular matrix, extracellular region, ...
Function	collagen binding, heparin binding

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (30)    Tissues (18)    Images (3)
Theiler Stages: 16, 17, 23, 28

Assay Type	Results
RNA in situ	14
Northern blot	16

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(1) cDNA(22) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000037253 (Evidence)
Ensembl Gene Model	ENSMUSG00000033327 (Evidence)
Entrez Gene	81877 (Evidence)
UniGene	290527
DFCI	TC1597629, TC1774436
DoTS	DT.102558962, DT.525221
NIA Mouse Gene Index	U017866
Consensus CDS Project	CCDS28656.2
International Mouse Knockout Project Status	Tnxb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037253	VEGA Gene Model | MGI Sequence Detail	49281	C57BL/6J
transcript	OTTMUST00000096074	VEGA | MGI Sequence Detail	12209	Not Applicable
polypeptide	OTTMUSP00000053640	VEGA | MGI Sequence Detail	4006	Not Applicable

All sequences(32) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(277 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular
InterPro	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro	IPR014715	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro	IPR020837	Fibrinogen, conserved site
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
Protein Ontology	PR:000016524	tenascin-X

References

(Earliest) J:36890 Saga Y, et al., Mice develop normally without tenascin. Genes Dev. 1992 Oct;6(10):1821-31
(Latest) J:189446 Bonod-Bidaud C, et al., In vivo evidence for a bridging role of a collagen V subtype at the epidermis-dermis interface. J Invest Dermatol. 2012 Jul;132(7):1841-9
All references(56)

Other accession IDs

MGD-MRK-18691, MGI:101866