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Fkbpl Gene Detail
Summary
  • Symbol
    Fkbpl
  • Name
    FK506 binding protein-like
  • Synonyms
    DIR1, NG7, Ppiase-X, WAF-1/CIP1 stabilizing protein 39, WISp39
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932127
    NCBI Gene: 56299
  • Gene Overview
    MyGene.info: FKBPL
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:34644764-34646324 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1561 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.22 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FKBPL, FK506 binding protein like
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FKBPL, FK506 binding protein like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DIR1, FKBP4, NG7, WISP39
  • Links
    NCBI Gene ID: 63943
    neXtProt AC: NX_Q9UIM3
    UniProt: Q9UIM3

  • Chr Location
    6p21.32; chr6:32128707-32130290 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to complete embryonic lethality. Heterozygotes develop normally but exhibit enhanced angiogenesis in various experimental and tumor disease models.
Gene Ontology
(GO)
Classifications
less
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037080 VEGA Gene Model | MGI Sequence Detail 1561 C57BL/6J ±  kb
transcript OTTMUST00000095427 VEGA | MGI Sequence Detail 1270 Not Applicable  
polypeptide OTTMUSP00000053247 VEGA | MGI Sequence Detail 347 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    Genomic 1
    cDNA 29
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Phenotypes 8
  • Earliest
    J:63110 Martin AM, et al., Immunol Today. 2000;21(7):Centerfold
  • Latest
    J:226964 Yakkundi A, et al., FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):845-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory