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Fkbpl Gene Detail
Summary
  • Symbol
    Fkbpl
  • Name
    FK506 binding protein-like
  • Synonyms
    DIR1, NG7, Ppiase-X, WAF-1/CIP1 stabilizing protein 39, WISp39
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932127
    NCBI Gene: 56299
  • Gene Overview
    MyGene.info: FKBPL
Location & Maps
more
  • Sequence Map
    Chr17:34644764-34646324 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1561 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.22 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FKBPL, FK506 binding protein like
  • Vertebrate Orthologs
    7
  • Human Ortholog
    FKBPL, FK506 binding protein like
    Orthology source: HomoloGene
  • Synonyms
    DIR1, FKBP4, NG7, WISP39
  • Links
    NCBI Gene ID: 63943
    neXtProt AC: NX_Q9UIM3

  • Chr Location
    6p21.3; chr6:32128707-32130308 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    9
  • Targeted
    2
  • Incidental Mutations
Homozygous inactivation of this gene leads to complete embryonic lethality. Heterozygotes develop normally but exhibit enhanced angiogenesis in various experimental and tumor disease models.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037080 VEGA Gene Model | MGI Sequence Detail 1561 C57BL/6J ±  kb
transcript OTTMUST00000095427 VEGA | MGI Sequence Detail 1270 Not Applicable  
polypeptide OTTMUSP00000053247 VEGA | MGI Sequence Detail 347 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007546 FK506-binding protein-like
  • InterPro Domains
    IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
    IPR011990 Tetratricopeptide-like helical domain
    IPR019734 Tetratricopeptide repeat
    IPR001440 Tetratricopeptide repeat 1
    IPR013026 Tetratricopeptide repeat-containing domain
Molecular
Reagents
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  • All nucleic 31
    Genomic 1
    cDNA 29
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:63110 Martin AM, et al., Immunol Today. 2000;21(7):Centerfold
  • Latest
    J:226964 Yakkundi A, et al., FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):845-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory