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Prrt1 Gene Detail
Summary
  • Symbol
    Prrt1
  • Name
    proline-rich transmembrane protein 1
  • Synonyms
    G5b, NG5, SynDIG4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932118
    NCBI Gene: 260297
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34629533-34633126 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932118
protein coding gene Chr17:34629533-34633134 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023584
protein coding gene Chr17:34709504-34713162 (+)
A/J MGP_AJ_G0023546
protein coding gene Chr17:33527592-33531196 (+)
AKR/J MGP_AKRJ_G0023511
protein coding gene Chr17:33945703-33950822 (+)
BALB/cJ MGP_BALBcJ_G0023550
protein coding gene Chr17:33675431-33679627 (+)
C3H/HeJ MGP_C3HHeJ_G0023310
protein coding gene Chr17:34339780-34343142 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023990
protein coding gene Chr17:36034886-36038484 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021469
protein coding gene Chr17:31416144-31419741 (+)
CAST/EiJ MGP_CASTEiJ_G0022810
protein coding gene Chr17:34412623-34416914 (+)
CBA/J MGP_CBAJ_G0023288
protein coding gene Chr17:37557812-37561408 (+)
DBA/2J MGP_DBA2J_G0023416
protein coding gene Chr17:32817841-32821458 (+)
FVB/NJ MGP_FVBNJ_G0023383
protein coding gene Chr17:32721968-32725556 (+)
LP/J MGP_LPJ_G0023494
protein coding gene Chr17:34981282-34984879 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023406
protein coding gene Chr17:36445758-36449376 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024033
protein coding gene Chr17:34254799-34258372 (+)
PWK/PhJ MGP_PWKPhJ_G0022558
protein coding gene Chr17:31746834-31750425 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022375
protein coding gene Chr17:32240271-32245664 (+)
WSB/EiJ MGP_WSBEiJ_G0022871
protein coding gene Chr17:34349568-34352929 (+)



Homology
more
  • Human Ortholog
    PRRT1, proline rich transmembrane protein 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    PRRT1, proline rich transmembrane protein 1
    Orthology source: HGNC
  • Synonyms
    C6orf31, DSPD1, IFITMD7, NG5
  • Links
    NCBI Gene ID: 80863
    neXtProt AC: NX_Q99946
    UniProt: Q99946

  • Chr Location
    6p21.32; chr6:32148363-32151943 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced mEPSC, reduced LTP, impaired spatial learning, decreased object recognition and increased exploration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015476 Ensembl Gene Model | MGI Sequence Detail 3594 C57BL/6J ±  kb
transcript ENSMUST00000015620 Ensembl | MGI Sequence Detail 1940 Not Applicable  
polypeptide ENSMUSP00000015620 Ensembl | MGI Sequence Detail 306 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 11
    Genomic 1
    cDNA 10

    Microarray probesets 1
References
more
  • Summaries
    All 23
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:63110 Martin AM, et al., Immunol Today. 2000;21(7):Centerfold
  • Latest
    J:260353 Matt L, et al., SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function. Cell Rep. 2018 Feb 27;22(9):2246-2253

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory