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Papolb
Gene Detail
 Symbol
Name
ID
Papolb
poly (A) polymerase beta (testis specific)
MGI:1932115
Synonyms Papola-ps, Papt, Plap-ps, TPAP
Feature Type protein coding gene
Genetic Map
Chromosome 5
81.53 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:142525838-142530076 bp, - strand
From VEGA annotation of GRCm38

  4239 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121622  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: poly(A) polymerase
Gene Tree: Papolb

Human
homologs
Human Homolog PAPOLB, poly(A) polymerase beta (testis specific)
NCBI Gene ID 56903
neXtProt AC  NX_Q9NRJ5
Human Synonyms  PAPT, TPAP
Human Chr (Location)  7p22.1; chr7:4857738-4861994 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit male infertility associated with reduced testes weight, smaller seminiferous tubules, and arrested spermiogenesis.
 
Interactions
Papolb interacts with 313 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process mRNA polyadenylation, mRNA processing, ...
Component cytoplasm, endoplasmic reticulum, ...
Function ATP binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (1)   
Theiler Stages: 28
Assay TypeResults
RT-PCR 3
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) Genomic(1) cDNA(4) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026090 (Evidence)
Ensembl Gene ModelENSMUSG00000074817 (Evidence)
Entrez Gene56522 (Evidence)
DFCITC1584910, TC1625080
DoTSDT.40137948, DT.60101968
NIA Mouse Gene IndexU026902
EC2.7.7.19
Consensus CDS ProjectCCDS39362.1
International Mouse Knockout Project StatusPapolb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026090 VEGA Gene Model | MGI Sequence Detail 4239 C57BL/6J ±  kb
transcript OTTMUST00000064413 VEGA | MGI Sequence Detail 4239 Not Applicable 
polypeptide OTTMUSP00000031979 VEGA | MGI Sequence Detail 642 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011068 Nucleotidyltransferase, class I, C-terminal-like
InterPro IPR002934 Nucleotidyl transferase domain
InterPro IPR014492 Poly(A) polymerase
InterPro IPR007012 Poly(A) polymerase, central domain
InterPro IPR007010 Poly(A) polymerase, RNA-binding domain
Protein Ontology PR:000012268 poly(A) polymerase beta
References (Earliest) J:33284 Zhao W, et al., Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Mol Cell Biol. 1996 May;16(5):2378-86
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Other
accession IDs
MGD-MRK-38345, MGI:109300, MGI:1931138

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory