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Papolb Gene Detail
Summary
  • Symbol
    Papolb
  • Name
    poly (A) polymerase beta (testis specific)
  • Synonyms
    Papola-ps, Papt, Plap-ps, TPAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932115
    NCBI Gene: 56522
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:142513495-142515831 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 81.53 cM, cytoband G2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932115
 protein coding gene Chr5:142511593-142515831 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030313
 protein coding gene Chr5:147765417-147769655 (-)
A/J MGP_AJ_G0030282
 protein coding gene Chr5:141440809-141445047 (-)
AKR/J MGP_AKRJ_G0030214
 protein coding gene Chr5:145850692-145854930 (-)
BALB/cJ MGP_BALBcJ_G0030299
 protein coding gene Chr5:142689070-142693308 (-)
C3H/HeJ MGP_C3HHeJ_G0030010
 protein coding gene Chr5:146674576-146678814 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030744
 protein coding gene Chr5:153181099-153185337 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027962
 protein coding gene Chr5:135259697-135263932 (-)
CAST/EiJ MGP_CASTEiJ_G0029415
 protein coding gene Chr5:146126516-146130753 (-)
CBA/J MGP_CBAJ_G0029980
 protein coding gene Chr5:159441224-159445462 (-)
DBA/2J MGP_DBA2J_G0030130
 protein coding gene Chr5:141216252-141220490 (-)
FVB/NJ MGP_FVBNJ_G0030085
 protein coding gene Chr5:140406317-140410555 (-)
LP/J MGP_LPJ_G0030216
 protein coding gene Chr5:148382144-148386382 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030116
 protein coding gene Chr5:161946314-161950552 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030784
 protein coding gene Chr5:145706497-145710735 (-)
PWK/PhJ MGP_PWKPhJ_G0029130
 protein coding gene Chr5:140284443-140288685 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028966
 protein coding gene Chr5:143444698-143448925 (-)
WSB/EiJ MGP_WSBEiJ_G0029489
 protein coding gene Chr5:146503094-146507332 (-)



Homology
more
  • Human Ortholog
    PAPOLB, poly(A) polymerase beta
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAPOLB, poly(A) polymerase beta
  • Synonyms
    PAPT, TPAP
  • Links
    NCBI Gene ID: 56903
    neXtProt AC: NX_Q9NRJ5
    UniProt: Q9NRJ5

  • Chr Location
    7p22.1; chr7:4857738-4862030 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit male infertility associated with reduced testes weight, smaller seminiferous tubules, and arrested spermiogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    4
  • cDNA Data
    5
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56522 NCBI Gene Model | MGI Sequence Detail 2337 C57BL/6J ±  kb
    transcript NM_019943 RefSeq | MGI Sequence Detail 2337 Not Specified  
    polypeptide Q9WVP6 UniProt | EBI | MGI Sequence Detail 642 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      Genomic 1
      cDNA 5
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38345, MGI:109300, MGI:1931138
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:33284 Zhao W, et al., Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Mol Cell Biol. 1996 May;16(5):2378-86
    • Latest
      J:319274 Kashiwabara SI, et al., PAPOLB/TPAP regulates spermiogenesis independently of chromatoid body-associated factors. J Reprod Dev. 2018 Feb 27;64(1):25-31
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory