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Jdp2 Gene Detail
Summary
  • Symbol
    Jdp2
  • Name
    Jun dimerization protein 2
  • Synonyms
    Jundm2, TIF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932093
    NCBI Gene: 81703
Location & Maps
more
  • Sequence Map
    Chr12:85599105-85639878 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40774 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    JDP2, Jun dimerization protein 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    JDP2, Jun dimerization protein 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    JUNDM2
  • Links
    NCBI Gene ID: 122953
    neXtProt AC: NX_Q8WYK2

  • Chr Location
    14q24.3; chr14:75427806-75472701 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 4 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Targeted
    6
  • Genomic Mutations
    1 involving Jdp2
  • Incidental Mutations
    APF
Mice homozygous for a null allele exhibit increased white adipose tissue differentiation, short tail, and enhanced would healing due to increased cell proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034271 Ensembl Gene Model | MGI Sequence Detail 40774 C57BL/6J ±  kb
transcript ENSMUST00000177587 Ensembl | MGI Sequence Detail 1567 Not Applicable  
polypeptide ENSMUSP00000136823 Ensembl | MGI Sequence Detail 163 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    104 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000009210 jun dimerization protein 2
  • InterPro Domains
    IPR000837 AP-1 transcription factor
    IPR004827 Basic-leucine zipper domain
    IPR029819 Jun dimerization protein 2
Molecular
Reagents
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  • All nucleic 5
    cDNA 5

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:67261 Jin C, et al., Identification of mouse Jun dimerization protein 2 as a novel repressor of ATF-2. FEBS Lett. 2001 Jan 26;489(1):34-41
  • Latest
    J:210368 Yao C, et al., The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and plays an important role in osteoclastogenesis. J Biol Chem. 2014 Mar 7;289(10):6775-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory