Sil1
Gene Detail

Symbol Name ID

Sil1 endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae) MGI:1932040

Synonyms

1810057E01Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 18

18.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:35266400-35498925 bp, - strand From Ensembl annotation of GRCm38   232526 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32544  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Sil1

Human homologs

Human Homolog		SIL1, SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
NCBI Gene ID		64374
neXtProt AC		NX_Q9H173
Human Synonyms		BAP, MSS, ULG5
Human Chr (Location)		5q31; chr5:138282409-138534065 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SIL1

Alleles and phenotypes

All alleles(22) : Targeted(2) Gene trapped(19) Spontaneous(1)
 

Mice homozygous for a gene trapped allele or spontaneous mutation exhibit ataxia and Purkinje cell degeneration.

 
Human Diseases Modeled Using Mouse Sil1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Process	protein transport, transport
Component	endoplasmic reticulum

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (81)    Tissues (20)    Images (41)
Theiler Stages: 20, 23, 28

Assay Type	Results
Immunohistochemistry	14
RNA in situ	67

cDNA source data(68)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(68) cDNA(68)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000024357 (Evidence)
Entrez Gene	81500 (Evidence)
UniGene	291482
DFCI	TC1576410, TC1642134, TC1726855
DoTS	DT.489567, DT.91446863
NIA Mouse Gene Index	U038320
Consensus CDS Project	CCDS29140.1
International Mouse Knockout Project Status	Sil1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024357	Ensembl Gene Model | MGI Sequence Detail	232526	C57BL/6J
transcript	ENSMUST00000025215	Ensembl | MGI Sequence Detail	1695	Not Applicable
polypeptide	ENSMUSP00000025215	Ensembl | MGI Sequence Detail	465	Not Applicable

All sequences(31) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(728 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
Protein Ontology	PR:000014873	nucleotide exchange factor SIL1

References

(Earliest) J:66100 Tyson JR, et al., LHS1 and SIL1 provide a lumenal function that is essential for protein translocation into the endoplasmic reticulum. EMBO J. 2000 Dec 1;19(23):6440-52
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)

Other accession IDs

MGI:1923775, MGI:2147193, MGI:2182806