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Sil1
Gene Detail
Symbol

Name
ID
Sil1
endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)
MGI:1932040
Synonyms
1810057E01Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 18
18.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:35266400-35498925 bp, - strand
From Ensembl annotation of GRCm38

  232526 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32544  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SIL1
Gene Tree: Sil1

Human
homologs
SIL1, SIL1 nucleotide exchange factor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 64374
neXtProt AC: NX_Q9H173

Human Synonyms: BAP, MSS, ULG5

Human Chr (Location): 5q31; chr5:138946720-139198376 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SIL1

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(19) Spontaneous(1) Targeted(2)
Incidental mutations (data from CvDC )
 
Mice homozygous for a gene trapped allele or spontaneous mutation exhibit ataxia and Purkinje cell degeneration.
 
Human Diseases Modeled in Mice Using Sil1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Sil1 interacts with 41 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process protein transport, transport
Component endoplasmic reticulum, extracellular space
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (81)    Tissues (20)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 67
cDNA source data(67)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sil1    NEW 
Molecular
reagents
All nucleic(67) cDNA(67)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000024357 (Evidence)
Entrez Gene 81500 (Evidence)
UniGene 291482
DFCI TC1642134, TC1576410, TC1726855
DoTS DT.91446863, DT.489567
NIA Mouse Gene Index U038320
Consensus CDS Project CCDS29140.1
International Mouse Phenotyping Consortium Status Sil1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024357 Ensembl Gene Model | MGI Sequence Detail 232526 C57BL/6J ±  kb
transcript ENSMUST00000025215 Ensembl | MGI Sequence Detail 1695 Not Applicable 
polypeptide ENSMUSP00000025215 Ensembl | MGI Sequence Detail 465 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(1195 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
Protein Ontology PR:000014873 nucleotide exchange factor SIL1
References
(Earliest) J:66100 Tyson JR, et al., LHS1 and SIL1 provide a lumenal function that is essential for protein translocation into the endoplasmic reticulum. EMBO J. 2000 Dec 1;19(23):6440-52
(Latest) J:213749 Ittner AA, et al., The nucleotide exchange factor SIL1 is required for glucose-stimulated insulin secretion from mouse pancreatic beta cells in vivo. Diabetologia. 2014 Jul;57(7):1410-9
All references(34)
Disease annotation references (1)
Other
accession IDs
MGI:1923775, MGI:2147193, MGI:2182806

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory