Dnajb12 MGI Mouse Gene Detail - MGI:1931881 - DnaJ heat shock protein family (Hsp40) member B12

Symbol

Dnajb12
Name

DnaJ heat shock protein family (Hsp40) member B12
Synonyms

mDj10

Feature Type

protein coding gene
IDs

MGI:1931881
NCBI Gene: 56709
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr10:59715405-59735118 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 29.64 cM, cytoband B3
Mapping Data

3 experiments

SNPs within 2kb

44 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931881	protein coding gene	Chr10:59715378-59735124 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017261	protein coding gene	Chr10:59064841-59085340 (+)
A/J	MGP_AJ_G0017239	protein coding gene	Chr10:57336444-57356190 (+)
AKR/J	MGP_AKRJ_G0017197	protein coding gene	Chr10:58803879-58823625 (+)
BALB/cJ	MGP_BALBcJ_G0017199	protein coding gene	Chr10:57430242-57450331 (+)
C3H/HeJ	MGP_C3HHeJ_G0017022	protein coding gene	Chr10:58742915-58762894 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017657	protein coding gene	Chr10:61186551-61207589 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015348	protein coding gene	Chr10:54360670-54380405 (+)
CAST/EiJ	MGP_CASTEiJ_G0016593	protein coding gene	Chr10:58671348-58691909 (+)
CBA/J	MGP_CBAJ_G0016994	protein coding gene	Chr10:63361733-63384001 (+)
DBA/2J	MGP_DBA2J_G0017099	protein coding gene	Chr10:56646685-56667801 (+)
FVB/NJ	MGP_FVBNJ_G0017093	protein coding gene	Chr10:55883119-55902863 (+)
LP/J	MGP_LPJ_G0017174	protein coding gene	Chr10:59441166-59460894 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017121	protein coding gene	Chr10:65864845-65884911 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017695	protein coding gene	Chr10:58630025-58649758 (+)
PWK/PhJ	MGP_PWKPhJ_G0016376	protein coding gene	Chr10:56454019-56475317 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016159	protein coding gene	Chr10:57974450-57994326 (+)
WSB/EiJ	MGP_WSBEiJ_G0016657	protein coding gene	Chr10:58542908-58562644 (+)

Human Ortholog

DNAJB12, DnaJ heat shock protein family (Hsp40) member B12

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJB12, DnaJ heat shock protein family (Hsp40) member B12
Synonyms

DJ10
Links

HGNC:14891

NCBI Gene ID: 54788

neXtProt AC: NX_Q9NXW2

UniProt: Q9NXW2
Chr Location

10q22.1; chr10:72332830-72355149 (-) GRCh38

MGI Vertebrate Homology

Dnajb12 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DNAJB12
Gene Tree

Dnajb12

less

Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

4
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Dnajb12
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

19
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

759
Tissues

46
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnajb12

ZFIN dnajb12a

less

All Sequences

53
RefSeq

6
UniProt

3
CCDS

CCDS23867.1, CCDS88010.1

Ensembl

ENSMUSG00000020109 (Evidence)
NCBI Gene

56709

			Length	Strain/Species	Flank
genomic	56709	NCBI Gene Model \| MGI Sequence Detail	19714	C57BL/6J	± kb
transcript	NM_019965	RefSeq \| MGI Sequence Detail	3062	C57BL/6
polypeptide	Q9QYI4	UniProt \| EBI \| MGI Sequence Detail	376	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000031187 DnaJ homolog subfamily B member 12

(term hierarchy)
InterPro Domains

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR018253 DnaJ domain, conserved site

IPR015399 Domain of unknown function DUF1977, DnaJ-like

less

All nucleic 11

cDNA 11

Microarray probesets 4

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682

TSS for Dnajb12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93495	Chr10:59715391-59715435 (+)	8 bp
Tssr93496	Chr10:59715439-59715504 (+)	67 bp
Tssr93497	Chr10:59734857-59734861 (+)	19,454 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23