About   Help   FAQ
Dnajb1 Gene Detail
Summary
  • Symbol
    Dnajb1
  • Name
    DnaJ heat shock protein family (Hsp40) member B1
  • Synonyms
    0610007I11Rik, Hsp40
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931874
    NCBI Gene: 81489
  • Gene Overview
    MyGene.info: DNAJB1
Location & Maps
more
  • Sequence Map
    Chr8:83608175-83611902 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3728 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 40.22 cM, cytoband C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DNAJB1, DnaJ heat shock protein family (Hsp40) member B1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNAJB1, DnaJ heat shock protein family (Hsp40) member B1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Hdj1, Hsp40, HSPF1, RSPH16B, Sis1
  • Links
    NCBI Gene ID: 3337
    neXtProt AC: NX_P25685

  • Chr Location
    19p13.2; chr19:14514764-14529711 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    33 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Dnajb1
  • Incidental Mutations
Mice homozygous for a knock-out allele are viable, fertile, and overtly normal; however, homozygous null peritoneal macrophages display impaired thermotolerance in the early (but not in the late) phase after mild heat treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005483 Ensembl Gene Model | MGI Sequence Detail 3728 C57BL/6J ±  kb
transcript ENSMUST00000005620 Ensembl | MGI Sequence Detail 2263 Not Applicable  
polypeptide ENSMUSP00000005620 Ensembl | MGI Sequence Detail 340 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    37 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 4
Other
Accession IDs
less
MGI:1915569
References
more
  • Summaries
    All 33
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 33
  • Earliest
    J:67976 Hata M, et al., Cloning and expression of murine Hsp40 gene: differences in initiation sites between heat-induced and constitutive transcripts. DNA Seq. 2000;11(3-4):213-23
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory