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Nckipsd Gene Detail
Summary
  • Symbol
    Nckipsd
  • Name
    NCK interacting protein with SH3 domain
  • Synonyms
    AF3P21, DIP1, ORF1, SPIN90, Wasbp, WISH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931834
    NCBI Gene: 80987
  • Gene Overview
    MyGene.info: NCKIPSD
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108808346-108818453 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.63 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931834
protein coding gene Chr9:108808346-108818844 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035313
protein coding gene Chr9:110799360-110809837 (+)
A/J MGP_AJ_G0035292
protein coding gene Chr9:106732009-106742516 (+)
AKR/J MGP_AKRJ_G0035224
protein coding gene Chr9:109410738-109421234 (+)
BALB/cJ MGP_BALBcJ_G0035286
protein coding gene Chr9:106426363-106436870 (+)
C3H/HeJ MGP_C3HHeJ_G0034996
protein coding gene Chr9:109809676-109820171 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035806
protein coding gene Chr9:113820628-113831091 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032704
protein coding gene Chr9:104143799-104154188 (+)
CAST/EiJ MGP_CASTEiJ_G0034307
protein coding gene Chr9:109774948-109785436 (+)
CBA/J MGP_CBAJ_G0034964
protein coding gene Chr9:117842938-117853420 (+)
DBA/2J MGP_DBA2J_G0035125
protein coding gene Chr9:106187084-106197587 (+)
FVB/NJ MGP_FVBNJ_G0035073
protein coding gene Chr9:104953985-104964492 (+)
LP/J MGP_LPJ_G0035201
protein coding gene Chr9:110988060-110998528 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035112
protein coding gene Chr9:119397420-119407926 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035827
protein coding gene Chr9:109686271-109696778 (+)
PWK/PhJ MGP_PWKPhJ_G0034014
protein coding gene Chr9:106518490-106529015 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033849
protein coding gene Chr9:109749843-109760320 (+)
WSB/EiJ MGP_WSBEiJ_G0034428
protein coding gene Chr9:109578771-109589240 (+)



Homology
more
  • Human Ortholog
    NCKIPSD, NCK interacting protein with SH3 domain
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NCKIPSD, NCK interacting protein with SH3 domain
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AF3P21, DIP, DIP1, ORF1, SPIN90, VIP54, WASLBP, WISH
  • Links
    NCBI Gene ID: 51517
    neXtProt AC: NX_Q9NZQ3
    UniProt: Q9NZQ3

  • Chr Location
    3p21.31; chr3:48663814-48685941 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation exhibit altered protein composition of postsynaptic densities and actin cytoskeleton in hippocampal neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 80987 NCBI Gene Model | MGI Sequence Detail 10108 C57BL/6J ±  kb
transcript NM_030729 RefSeq | MGI Sequence Detail 2870 C57BL/6  
polypeptide Q9ESJ4 UniProt | EBI | MGI Sequence Detail 714 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 37

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:67259 Fukuoka M, et al., A novel neural wiskott-aldrich syndrome protein (n-wasp) binding protein, wish, induces arp2/3 complex activation independent of cdc42. J Cell Biol. 2001 Feb 5;152(3):471-82
  • Latest
    J:245726 You E, et al., SPIN90 Depletion and Microtubule Acetylation Mediate Stromal Fibroblast Activation in Breast Cancer Progression. Cancer Res. 2017 Sep 01;77(17):4710-4722

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory