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Fgf16
Gene Detail
Symbol

Name
ID
Fgf16
fibroblast growth factor 16
MGI:1931627
Feature Type
protein coding gene
Genetic Map
Chromosome X
47.20 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:105764279-105774939 bp, + strand
From VEGA annotation of GRCm38

  10661 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11057  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FGF16
Protein SuperFamily: fibroblast growth factor
Gene Tree: Fgf16

Human
homologs
FGF16, fibroblast growth factor 16
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8823
neXtProt AC: NX_O43320

Human Synonyms: FGF-16, MF4

Human Chr (Location): Xq13; chrX:77447675-77456522 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from CvDC )
 
Males hemizygous for one null allele show reduced fetal cardiomyocyte proliferation and postnatal cardiomyocyte numbers. Males hemizygous for another null allele die in midgestation with craniofacial and heart defects including cardiac hemorrhage, chamber dilation, thin walls and poor trabeculation.
 
Interactions
Fgf16 interacts with 236 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (19 records)
Data Summary: Results (269)    Tissues (212)    Images (67)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 210
RT-PCR 59
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FGF16 ZFIN fgf16    NEW 
Molecular
reagents
All nucleic(13) cDNA(5) Primer pair(6) Other(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000018263 (Evidence)
Ensembl Gene Model ENSMUSG00000031230 (Evidence)
Entrez Gene 80903 (Evidence)
UniGene 154768
DFCI TC1624902, TC1725258
DoTS DT.91331229, DT.91334561
NIA Mouse Gene Index U020118
Consensus CDS Project CCDS30336.1
International Mouse Phenotyping Consortium Status Fgf16
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018263 VEGA Gene Model | MGI Sequence Detail 10661 C57BL/6J ±  kb
transcript OTTMUST00000044128 VEGA | MGI Sequence Detail 1645 Not Applicable 
polypeptide OTTMUSP00000019838 VEGA | MGI Sequence Detail 207 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007485 fibroblast growth factor 16
References
(Earliest) J:45662 Miyake A, et al., Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family. Biochem Biophys Res Commun. 1998 Feb 4;243(1):148-52
(Latest) J:215290 Matsumoto E, et al., Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16. Genes Cells. 2013 Jul;18(7):544-53
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory