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Rhoj Gene Detail
Summary
  • Symbol
    Rhoj
  • Name
    ras homolog family member J
  • Synonyms
    1110005O19Rik, Arhj, TC10L, TCL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931551
    NCBI Gene: 80837
  • Gene Overview
    MyGene.info: RHOJ
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:75308322-75401456 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      93135 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 32.63 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RHOJ, ras homolog family member J
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RHOJ, ras homolog family member J
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARHJ, RASL7B, TC10B, TCL
  • Links
    NCBI Gene ID: 57381
    neXtProt AC: NX_Q9H4E5
    UniProt: Q9H4E5

  • Chr Location
    14q23.2; chr14:63204127-63293512 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 4 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    5 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a slight delay in radial growth in the retina and empty basement membrane sleeves.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000027646 VEGA Gene Model | MGI Sequence Detail 93135 C57BL/6J ±  kb
    transcript OTTMUST00000068407 VEGA | MGI Sequence Detail 2350 Not Applicable  
    polypeptide OTTMUSP00000034579 VEGA | MGI Sequence Detail 214 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      784 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 64

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1914157, MGI:2145016
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:65771 Vignal E, et al., Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42. J Biol Chem. 2000 Nov 17;275(46):36457-64
    • Latest
      J:244004 Ruiz R, et al., The RhoJ-BAD signaling network: An Achilles' heel for BRAF mutant melanomas. PLoS Genet. 2017 Jul;13(7):e1006913

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory