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Hist1h1e Gene Detail
Summary
  • Symbol
    Hist1h1e
  • Name
    histone cluster 1, H1e
  • Synonyms
    H1-4, H1e, H1f4, H1s-4, H1var2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931527
    NCBI Gene: 50709
  • Member of
    Hist1 cluster
  • Gene Overview
    MyGene.info: HIST1H1E
Location & Maps
more
  • Sequence Map
    Chr13:23621755-23622502 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      748 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 9.83 cM, cytoband A3.2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HIST1H1E, histone cluster 1 H1 family member e
  • Vertebrate Orthologs
    2
  • Human Ortholog
    HIST1H1E, histone cluster 1 H1 family member e
    Orthology source: HGNC
  • Synonyms
    dJ221C16.5, H1.4, H1E, H1F4, H1s-4
  • Links
    NCBI Gene ID: 3008
    neXtProt AC: NX_P10412

  • Chr Location
    6p21.3; chr6:26156331-26157115 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    22 phenotypes from multigenic genotypes
    12 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Hist1h1e
  • Incidental Mutations
    APF
Homozygotes for targeted null mutations are normal, but Hist1h1e/Hist1h1c double knockout males are significantly smaller than normal. The Hist1h1e/Hist1h1d/Hist1h1e triple knockout is lethal by embryonic day 12.5, and heterozygotes are underrepresented.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000564 VEGA Gene Model | MGI Sequence Detail 748 C57BL/6J ±  kb
transcript OTTMUST00000001151 VEGA | MGI Sequence Detail 748 Not Applicable  
polypeptide OTTMUSP00000000532 VEGA | MGI Sequence Detail 219 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    23 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 3
    Genomic 1
    cDNA 1
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:18166 Dong Y, et al., Isolation and characterization of two replication-dependent mouse H1 histone genes. Nucleic Acids Res. 1994 Apr 25;22(8):1421-8
  • Latest
    J:223052 Cao K, et al., High-resolution mapping of h1 linker histone variants in embryonic stem cells. PLoS Genet. 2013;9(4):e1003417

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory