About   Help   FAQ
Hist1h1a Gene Detail
Summary
  • Symbol
    Hist1h1a
  • Name
    histone cluster 1, H1a
  • Synonyms
    H1.1, H1a, H1f1, H1var3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931523
    NCBI Gene: 80838
  • Member of
    Hist1 cluster
  • Gene Overview
    MyGene.info: HIST1H1A
Location & Maps
more
  • Sequence Map
    Chr13:23763717-23764358 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      642 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 9.91 cM, cytoband A3.2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HIST1H1A, histone cluster 1 H1 family member a
  • Vertebrate Orthologs
    3
  • Human Ortholog
    HIST1H1A, histone cluster 1 H1 family member a
    Orthology source: HGNC
  • Synonyms
    H1.1, H1A, H1F1, HIST1
  • Links
    NCBI Gene ID: 3024
    neXtProt AC: NX_Q02539

  • Chr Location
    6p21.3; chr6:26017032-26017812 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    14 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Hist1h1a
  • Incidental Mutations
Mice homozygous for a targeted null mutation are viable, fertile and do not exhibit any defects in the reproductive system or in spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000741 VEGA Gene Model | MGI Sequence Detail 642 C57BL/6J ±  kb
transcript OTTMUST00000001395 VEGA | MGI Sequence Detail 642 Not Applicable  
polypeptide OTTMUSP00000000668 VEGA | MGI Sequence Detail 213 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    43 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR005819 Histone H5
    IPR005818 Linker histone H1/H5, domain H15
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
less
  • All nucleic 3
    Genomic 1
    cDNA 2

    Microarray probesets 1
References
more
  • Summaries
    All 27
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:18166 Dong Y, et al., Isolation and characterization of two replication-dependent mouse H1 histone genes. Nucleic Acids Res. 1994 Apr 25;22(8):1421-8
  • Latest
    J:166749 Hammock EA, et al., Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain. Neural Dev. 2010;5(1):32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory