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Dbr1 Gene Detail
Summary
  • Symbol
    Dbr1
  • Name
    debranching RNA lariats 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931520
    NCBI Gene: 83703
  • Gene Overview
    MyGene.info: DBR1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:99575775-99584461 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 51.86 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931520
protein coding gene Chr9:99575775-99584501 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035171
protein coding gene Chr9:100951489-100960601 (+)
A/J MGP_AJ_G0035152
protein coding gene Chr9:97390938-97399728 (+)
AKR/J MGP_AKRJ_G0035084
protein coding gene Chr9:99764007-99772709 (+)
BALB/cJ MGP_BALBcJ_G0035145
protein coding gene Chr9:97077688-97086402 (+)
C3H/HeJ MGP_C3HHeJ_G0034855
protein coding gene Chr9:100159152-100167898 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035665
protein coding gene Chr9:103841041-103849743 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032564
protein coding gene Chr9:95122627-95132851 (+)
CAST/EiJ MGP_CASTEiJ_G0034166
protein coding gene Chr9:99982242-99990974 (+)
CBA/J MGP_CBAJ_G0034823
protein coding gene Chr9:107407200-107415893 (+)
DBA/2J MGP_DBA2J_G0034985
protein coding gene Chr9:96899291-96908510 (+)
FVB/NJ MGP_FVBNJ_G0034933
protein coding gene Chr9:95721533-95730339 (+)
LP/J MGP_LPJ_G0035061
protein coding gene Chr9:101200000-101208732 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034972
protein coding gene Chr9:109306567-109315271 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035687
protein coding gene Chr9:100010099-100024022 (+)
PWK/PhJ MGP_PWKPhJ_G0033873
protein coding gene Chr9:97116811-97125537 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033708
protein coding gene Chr9:100072195-100080946 (+)
WSB/EiJ MGP_WSBEiJ_G0034286
protein coding gene Chr9:99895879-99905915 (+)



Homology
more
  • Human Ortholog
    DBR1, debranching RNA lariats 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DBR1, debranching RNA lariats 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 51163
    neXtProt AC: NX_Q9UK59
    UniProt: Q9UK59

  • Chr Location
    3q22.3; chr3:138160988-138174949 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9428
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DBR1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit impaired class switch recombination in B cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 83703 NCBI Gene Model | MGI Sequence Detail 8687 C57BL/6J ±  kb
transcript NM_031403 RefSeq | MGI Sequence Detail 2103 C57BL/6  
polypeptide Q923B1 UniProt | EBI | MGI Sequence Detail 550 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    cDNA 30

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143276
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:64827 Kim JW, et al., Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants. Nucleic Acids Res. 2000 Sep 15;28(18):3666-73
  • Latest
    J:223318 Zheng S, et al., Non-coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA. Cell. 2015 May 7;161(4):762-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory