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Selk Gene Detail
Summary
  • Symbol
    Selk
  • Name
    selenoprotein K
  • Synonyms
    1110001C03Rik, 30kDa, HSPC030
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931466
    NCBI Gene: 80795
Location & Maps
more
  • Sequence Map
    Chr14:29968308-29975074 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6767 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 18.36 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SELK, selenoprotein K
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SELK, selenoprotein K
    Orthology source: HomoloGene
  • Synonyms
    HSPC030, HSPC297, SelK
  • Links
    NCBI Gene ID: 58515
    neXtProt AC: NX_Q9Y6D0

  • Chr Location
    3p21.31; chr3:53885199-53891962 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    2
  • Targeted
    6
Mice homozygous for a knock-out allele exhibit impaired T cell, neutrophil, and macrophage calcium flux and increased susceptibility to viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020974 VEGA Gene Model | MGI Sequence Detail 6767 C57BL/6J ±  kb
transcript OTTMUST00000049602 VEGA | MGI Sequence Detail 1090 Not Applicable  
polypeptide OTTMUSP00000023011 VEGA | MGI Sequence Detail 94 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    41 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014609 selenoprotein K
  • InterPro Domains
    IPR024491 Selenoprotein SelK/SelG
Molecular
Reagents
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  • All nucleic 108
    cDNA 108

    Microarray probesets 3
Other
Accession IDs
less
MGI:1913387, MGI:2145576
References
more
  • Summaries
    All 38
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:216755 Fredericks GJ, et al., Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16478-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory