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Pycard
Gene Detail
 Symbol
Name
ID
Pycard
PYD and CARD domain containing
MGI:1931465
Synonyms 9130417A21Rik, Asc, TMS-1
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.88 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:127992103-127993867 bp, - strand
From VEGA annotation of GRCm38

  1765 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8307  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 8 western clawed frog

Gene Tree: Pycard

Human
homologs
Human Homolog PYCARD, PYD and CARD domain containing
NCBI Gene ID 29108
neXtProt AC  NX_Q9ULZ3
Human Synonyms  ASC, CARD5, TMS, TMS1, TMS-1
Human Chr (Location)  16p11.2; chr16:31201486-31202776 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene display abnormalities in interleukin production and secretion as well as increased resistance lethal effects of lipopolysaccharide.
 
Interactions
Pycard interacts with 107 markers (Mir15b, Mir26a-2, Mir26b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (82 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of innate immune response, ...
Component AIM2 inflammasome complex, cytoplasm, ...
Function ion channel binding, peptidase activator activity involved in apoptotic process, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (52)    Tissues (23)    Images (14)
Theiler Stages: 15, 16, 21, 22, 23, 28
Assay TypeResults
RNA in situ 42
Northern blot 10
cDNA source data(50)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) cDNA(50) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000025367 (Evidence)
Ensembl Gene ModelENSMUSG00000030793 (Evidence)
Entrez Gene66824 (Evidence)
UniGene24163
DFCITC1577872, TC1642670, TC1651134, TC1774929
DoTSDT.101377720, DT.103585944, DT.492485, DT.55257323, DT.94282864
Consensus CDS ProjectCCDS21888.1
International Mouse Knockout Project StatusPycard
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025367 VEGA Gene Model | MGI Sequence Detail 1765 C57BL/6J ±  kb
transcript OTTMUST00000062448 VEGA | MGI Sequence Detail 1405 Not Applicable 
polypeptide OTTMUSP00000030782 VEGA | MGI Sequence Detail 193 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001315 Caspase Recruitment
InterPro IPR004020 DAPIN domain
InterPro IPR011029 Death-like domain
Protein Ontology PR:000013514 apoptosis-associated speck-like protein containing a CARD
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211688 Wynosky-Dolfi MA, et al., Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome. J Exp Med. 2014 Apr 7;211(4):653-68
All references(235)
Other
accession IDs
MGI:1914074

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory