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Slc19a3
Gene Detail
Symbol

Name
ID
Slc19a3
solute carrier family 19, member 3
MGI:1931307
Synonyms
A230084E24Rik, ThTr2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
42.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:83012523-83038448 bp, - strand
From VEGA annotation of GRCm38

  25926 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23530  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

HCOP human homology predictions: SLC19A3
Protein SuperFamily: folate/thiamine transporter
Gene Tree: Slc19a3

Human
homologs
SLC19A3, solute carrier family 19 (thiamine transporter), member 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 80704
neXtProt AC: NX_Q9BZV2

Human Synonyms: BBGD, THMD2, THTR2

Human Chr (Location): 2q37; chr2:227685210-227718029 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC19A3

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit premature death within a year of age, impaired thiamin uptake, lethargy, cachexia, injured liver parenchyma, hepatic necrosis, liver and kidney inflammmation, and nephrosclerosis.
 
Interactions
Slc19a3 interacts with 210 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Expression
Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc19a3    NEW 
Molecular
reagents
All nucleic(9) cDNA(7) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000022622 (Evidence)
Ensembl Gene Model ENSMUSG00000038496 (Evidence)
Entrez Gene 80721 (Evidence)
UniGene 261542
DFCI TC1623692, TC1613767, TC1594743
DoTS DT.97408352, DT.40146868, DT.110921102
NIA Mouse Gene Index U021538
Consensus CDS Project CCDS15101.1
International Mouse Phenotyping Consortium Status Slc19a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022622 VEGA Gene Model | MGI Sequence Detail 25926 C57BL/6J ±  kb
transcript OTTMUST00000054192 VEGA | MGI Sequence Detail 2974 Not Applicable 
polypeptide OTTMUSP00000025828 VEGA | MGI Sequence Detail 488 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(202 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR002666 Reduced folate carrier
Protein Ontology PR:000014971 thiamine transporter 2
References
(Earliest) J:67224 Eudy JD, et al., Identification and characterization of the human and mouse SLC19A3 gene: A novel member of the reduced folate family of micronutrient transporter genes. Mol Genet Metab. 2000 Dec;71(4):581-90
(Latest) J:183439 Subramanian VS, et al., Relative contribution of THTR-1 and THTR-2 in thiamin uptake by pancreatic acinar cells: studies utilizing Slc19a2 and Slc19a3 knockout mouse models. Am J Physiol Gastrointest Liver Physiol. 2012 Mar;302(5):G572-8
All references(32)
Other
accession IDs
MGI:2138321

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory