Slc19a3
Gene Detail

Symbol Name ID

Slc19a3 solute carrier family 19, member 3 MGI:1931307

Synonyms

A230084E24Rik, ThTr2

Feature Type

protein coding gene

Genetic Map

Chromosome 1

42.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:83012523-83038448 bp, - strand From VEGA annotation of GRCm38   25926 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:100033  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle; 1 dog

Protein SuperFamily: folate/thiamine transporter
Gene Tree: Slc19a3

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele exhibit premature death within a year of age, impaired thiamin uptake, lethargy, cachexia, injured liver parenchyma, hepatic necrosis, liver and kidney inflammmation, and nephrosclerosis.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	thiamine transport, transport
Component	integral to membrane, integral to plasma membrane, ...
Function	folic acid binding, reduced folate carrier activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23

Assay Type	Results
RNA in situ	1

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(7) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000022622 (Evidence)
Ensembl Gene Model	ENSMUSG00000038496 (Evidence)
Entrez Gene	80721 (Evidence)
UniGene	261542
DFCI	TC1594743, TC1613767, TC1623692
DoTS	DT.110921102, DT.40146868, DT.97408352
NIA Mouse Gene Index	U021538
Consensus CDS Project	CCDS15101.1
International Mouse Knockout Project Status	Slc19a3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022622	VEGA Gene Model | MGI Sequence Detail	25926	C57BL/6J
transcript	OTTMUST00000054192	VEGA | MGI Sequence Detail	2974	Not Applicable
polypeptide	OTTMUSP00000025828	VEGA | MGI Sequence Detail	488	Not Applicable

All sequences(30) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(54 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
InterPro	IPR002666	Reduced folate carrier
Protein Ontology	PR:000014971	thiamine transporter 2

References

(Earliest) J:67224 Eudy JD, et al., Identification and characterization of the human and mouse SLC19A3 gene: A novel member of the reduced folate family of micronutrient transporter genes. Mol Genet Metab. 2000 Dec;71(4):581-90
(Latest) J:183439 Subramanian VS, et al., Relative contribution of THTR-1 and THTR-2 in thiamin uptake by pancreatic acinar cells: studies utilizing Slc19a2 and Slc19a3 knockout mouse models. Am J Physiol Gastrointest Liver Physiol. 2012 Mar;302(5):G572-8
All references(33)

Other accession IDs

MGI:2138321