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Rab27b
Gene Detail
 Symbol
Name
ID
Rab27b
RAB27B, member RAS oncogene family
MGI:1931295
Synonyms 2310021G14Rik, B130064M09Rik
Feature Type protein coding gene
Genetic Map
Chromosome 18
43.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:69979131-70141605 bp, - strand
From VEGA annotation of GRCm38

  162475 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20879  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab27b

Human
homologs
Human Homolog RAB27B, RAB27B, member RAS oncogene family
NCBI Gene ID 5874
neXtProt AC  NX_O00194
Human Synonyms  C25KG
Human Chr (Location)  18q21.2; chr18:54717866-54895516 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one null allele exhibit impaired platelet aggregation.
 
Human Diseases Modeled Using Mouse Rab27b (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Rab27b interacts with 459 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process GTP catabolic process, multivesicular body sorting pathway, ...
Component apical plasma membrane, extracellular vesicular exosome, ...
Function GDP binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (298)    Tissues (30)    Images (23)
Theiler Stages: 23
Assay TypeResults
RNA in situ 298
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(22)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000028238 (Evidence)
Ensembl Gene ModelENSMUSG00000024511 (Evidence)
Entrez Gene80718 (Evidence)
UniGene246753
DFCITC1579706, TC1595361, TC1597917, TC1614610, TC1645351
DoTSDT.101338851, DT.40151575, DT.87039508, DT.91431696, DT.94187064, DT.94187071, DT.97412236
PDB2IEY, 2IEZ, 2ZET, 2IF0
Consensus CDS ProjectCCDS29331.1
International Mouse Knockout Project StatusRab27b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028238 VEGA Gene Model | MGI Sequence Detail 162475 C57BL/6J ±  kb
transcript OTTMUST00000069968 VEGA | MGI Sequence Detail 6891 Not Applicable 
polypeptide OTTMUSP00000035599 VEGA | MGI Sequence Detail 218 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(10) UniProt(4)
Polymorphisms SNPs within 2kb(1128 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003579 Small GTPase superfamily, Rab type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000013601 ras-related protein Rab-27B
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211540 Singh RK, et al., Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion. FEBS J. 2013 Feb;280(3):892-903
All references(46)
Disease annotation references (1)
Other
accession IDs
MGI:1916874, MGI:2445187

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory