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Rab27b Gene Detail
Summary
  • Symbol
    Rab27b
  • Name
    RAB27B, member RAS oncogene family
  • Synonyms
    2310021G14Rik, B130064M09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931295
    NCBI Gene: 80718
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:69979131-70141605 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 43.89 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1124 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931295
protein coding gene Chr18:69979131-70141633 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024540
protein coding gene Chr18:70430323-70601651 (-)
A/J MGP_AJ_G0024507
protein coding gene Chr18:67363152-67517661 (-)
AKR/J MGP_AKRJ_G0024478
protein coding gene Chr18:69316972-69481437 (-)
BALB/cJ MGP_BALBcJ_G0024507
protein coding gene Chr18:67508814-67666250 (-)
C3H/HeJ MGP_C3HHeJ_G0024275
protein coding gene Chr18:69440697-69606066 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024953
protein coding gene Chr18:72256302-72418004 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022384
protein coding gene Chr18:66677911-66827135 (-)
CAST/EiJ MGP_CASTEiJ_G0023748
protein coding gene Chr18:69564224-69729654 (-)
CBA/J MGP_CBAJ_G0024244
protein coding gene Chr18:74721799-74893613 (-)
DBA/2J MGP_DBA2J_G0024374
protein coding gene Chr18:66983655-67143603 (-)
FVB/NJ MGP_FVBNJ_G0024340
protein coding gene Chr18:66348015-66507809 (-)
LP/J MGP_LPJ_G0024458
protein coding gene Chr18:70297586-70458338 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024370
protein coding gene Chr18:75964622-76133300 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025001
protein coding gene Chr18:69501285-69665678 (-)
PWK/PhJ MGP_PWKPhJ_G0023492
protein coding gene Chr18:67338261-67494500 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023296
protein coding gene Chr18:69657804-69813701 (-)
WSB/EiJ MGP_WSBEiJ_G0023811
protein coding gene Chr18:69439222-69599708 (-)



Homology
more
  • Human Ortholog
    RAB27B, RAB27B, member RAS oncogene family
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RAB27B, RAB27B, member RAS oncogene family
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C25KG
  • Links
    NCBI Gene ID: 5874
    neXtProt AC: NX_O00194
    UniProt: O00194

  • Chr Location
    18q21.2; chr18:54717842-54895516 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Rab27b mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit impaired platelet aggregation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024511 Ensembl Gene Model | MGI Sequence Detail 162475 C57BL/6J ±  kb
transcript ENSMUST00000121693 Ensembl | MGI Sequence Detail 6891 Not Applicable  
polypeptide ENSMUSP00000114094 Ensembl | MGI Sequence Detail 218 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 6
Other
Accession IDs
less
MGI:1916874, MGI:2445187
References
more
  • Summaries
    All 57
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 8
    Phenotypes 17
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:270948 Sekine Y, et al., Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration. Cell Rep. 2018 Apr 10;23(2):415-428

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory