Rab27b
Gene Detail

Symbol Name ID

Rab27b RAB27b, member RAS oncogene family MGI:1931295

Synonyms

2310021G14Rik, B130064M09Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 18

43.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr18:69979131-70141605 bp, - strand From VEGA annotation of GRCm38   162475 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20879  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: Ras-related protein Rab
Gene Tree: Rab27b

Human homologs

Human Homolog		RAB27B, RAB27B, member RAS oncogene family
NCBI Gene ID		5874
neXtProt AC		NX_O00194
Human Synonyms		C25KG
Human Chr (Location)		18q21.2; chr18:52495708-52562747 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Mice homozygous for one null allele exhibit impaired platelet aggregation.

 
Human Diseases Modeled Using Mouse Rab27b (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	multivesicular body sorting pathway, positive regulation of exocytosis, ...
Component	apical plasma membrane, Golgi apparatus, ...
Function	GDP binding, GTPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (298)    Tissues (30)    Images (23)
Theiler Stages: 23

Assay Type	Results
RNA in situ	298

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(22)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000028238 (Evidence)
Ensembl Gene Model	ENSMUSG00000024511 (Evidence)
Entrez Gene	80718 (Evidence)
UniGene	246753
DFCI	TC1579706, TC1595361, TC1597917, TC1614610, TC1645351
DoTS	DT.101338851, DT.40151575, DT.87039508, DT.91431696, DT.94187064, DT.94187071, DT.97412236
PDB	2IEY, 2IEZ, 2ZET, 2IF0
Consensus CDS Project	CCDS29331.1
International Mouse Knockout Project Status	Rab27b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028238	VEGA Gene Model | MGI Sequence Detail	162475	C57BL/6J
transcript	OTTMUST00000069968	VEGA | MGI Sequence Detail	6891	Not Applicable
polypeptide	OTTMUSP00000035599	VEGA | MGI Sequence Detail	218	Not Applicable

All sequences(56) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(545 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001806	Small GTPase superfamily
InterPro	IPR003579	Small GTPase superfamily, Rab type
InterPro	IPR005225	Small GTP-binding protein domain
Protein Ontology	PR:000013601	ras-related protein Rab-27B

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:175669 Chiang L, et al., Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. Am J Physiol Cell Physiol. 2011 Aug;301(2):C507-21
All references(43)

Other accession IDs

MGI:1916874, MGI:2445187