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Parva Gene Detail
Summary
  • Symbol
    Parva
  • Name
    parvin, alpha
  • Synonyms
    2010012A22Rik, 5430400F08Rik, actopaxin, CH-ILKBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931144
    NCBI Gene: 57342
  • Gene Overview
    MyGene.info: PARVA
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:112427706-112591688 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 58.76 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2003 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931144
protein coding gene Chr7:112427505-112591692 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032870
protein coding gene Chr7:115999277-116177830 (+)
A/J MGP_AJ_G0032853
protein coding gene Chr7:113113859-113274928 (+)
AKR/J MGP_AKRJ_G0032785
protein coding gene Chr7:115960500-116119585 (+)
BALB/cJ MGP_BALBcJ_G0032858
protein coding gene Chr7:112807791-112971225 (+)
C3H/HeJ MGP_C3HHeJ_G0032568
protein coding gene Chr7:115951804-116120615 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033364
protein coding gene Chr7:120740704-120906906 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030336
protein coding gene Chr7:114709740-114872084 (+)
CAST/EiJ MGP_CASTEiJ_G0031896
protein coding gene Chr7:107565895-107730840 (+)
CBA/J MGP_CBAJ_G0032541
protein coding gene Chr7:124712809-124896719 (+)
DBA/2J MGP_DBA2J_G0032693
protein coding gene Chr7:111196720-111357896 (+)
FVB/NJ MGP_FVBNJ_G0032646
protein coding gene Chr7:111045600-111205012 (+)
LP/J MGP_LPJ_G0032787
protein coding gene Chr7:117512352-117680403 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032678
protein coding gene Chr7:126317969-126485911 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033384
protein coding gene Chr7:114959629-115121910 (+)
PWK/PhJ MGP_PWKPhJ_G0031603
protein coding gene Chr7:104035915-104189865 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031451
protein coding gene Chr7:101708554-101874991 (+)
WSB/EiJ MGP_WSBEiJ_G0032009
protein coding gene Chr7:115820809-115988570 (+)



Homology
more
  • Human Ortholog
    PARVA, parvin alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PARVA, parvin alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CH-ILKBP, MXRA2
  • Links
    NCBI Gene ID: 55742
    neXtProt AC: NX_Q9NVD7
    UniProt: Q9NVD7

  • Chr Location
    11p15.3; chr11:12376441-12535356 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10077
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PARVA
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a null allele are growth retarded and die prior to E14.5 exhibiting abnormal cardiac morphogenesis, severe vascular defects, edema, microaneurysms, hemorrhage, and severe kidney dysgenesis or agenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57342 NCBI Gene Model | MGI Sequence Detail 163983 C57BL/6J ±  kb
    transcript NM_020606 RefSeq | MGI Sequence Detail 4450 C57BL/6  
    polypeptide Q9EPC1 UniProt | EBI | MGI Sequence Detail 372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 188
      cDNA 185
      Primer pair 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1914044, MGI:1923778, MGI:2141883, MGI:2142158
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 9
      Gene Ontology 12
      Phenotypes 14
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:249178 Fraccaroli A, et al., Endothelial alpha-parvin controls integrity of developing vasculature and is required for maintenance of cell-cell junctions. Circ Res. 2015 Jun 19;117(1):29-40

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory