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Parva
Gene Detail
 Symbol
Name
ID
Parva
parvin, alpha
MGI:1931144
Synonyms 2010012A22Rik, 5430400F08Rik, actopaxin, CH-ILKBP
Feature Type protein coding gene
Genetic Map
Chromosome 7
58.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:112427505-112591692 bp, + strand
From VEGA annotation of GRCm38

  164188 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10077  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: parvin
Gene Tree: Parva

Human
homologs
Human Homolog PARVA, parvin, alpha
NCBI Gene ID 55742
neXtProt AC  NX_Q9NVD7
Human Synonyms  CH-ILKBP, MXRA2
Human Chr (Location)  11p15.3; chr11:12376441-12535356 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(10) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a null allele are growth retarded and die prior to E14.5 exhibiting abnormal cardiac morphogenesis, severe vascular defects, edema, microaneurysms, hemorrhage, and severe kidney dysgenesis or agenesis.
 
Interactions
Parva interacts with 413 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process actin cytoskeleton organization, actin cytoskeleton reorganization, ...
Component actin cytoskeleton, cell junction, ...
Function actin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (126)    Tissues (115)    Images (19)
Theiler Stages: 10, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 104
Northern blot 20
RT-PCR 2
cDNA source data(184)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(187) cDNA(184) Primer pair(3)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000024812 (Evidence)
Ensembl Gene ModelENSMUSG00000030770 (Evidence)
Entrez Gene57342 (Evidence)
UniGene143763
DFCITC1575498, TC1690739
DoTSDT.101198456, DT.101322007, DT.490717, DT.94148269, DT.94250691
Consensus CDS ProjectCCDS40091.1
International Mouse Knockout Project StatusParva
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024812 VEGA Gene Model | MGI Sequence Detail 164188 C57BL/6J ±  kb
transcript OTTMUST00000061109 VEGA | MGI Sequence Detail 2222 Not Applicable 
polypeptide OTTMUSP00000029905 VEGA | MGI Sequence Detail 372 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(2033 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001715 Calponin homology domain
Protein Ontology PR:000012303 alpha-parvin
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:199658 Moik D, et al., Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice. J Biol Chem. 2013 Jun 28;288(26):18863-71
All references(50)
Other
accession IDs
MGI:1914044, MGI:1923778, MGI:2141883, MGI:2142158

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory