About   Help   FAQ
Inpp4a
Gene Detail
 Symbol
Name
ID
Inpp4a
inositol polyphosphate-4-phosphatase, type I
MGI:1931123
Synonyms 107kDa
Feature Type protein coding gene
Genetic Map
Chromosome 1
15.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:37299865-37410736 bp, + strand
From VEGA annotation of GRCm38

  110872 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2871  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: inositol-3,4-bisphosphate 4-phosphatase type I/II
Gene Tree: Inpp4a

Human
homologs
Human Homolog INPP4A, inositol polyphosphate-4-phosphatase, type I, 107kDa
NCBI Gene ID 3631
neXtProt AC  NX_Q96PE3
Human Synonyms  INPP4, TVAS1
Human Chr (Location)  2q11.2; chr2:98444858-98591598 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a spontaneous mutation exhibit small size, ataxia, loss of cerebellar and hippocampal CA1 neurons, and death by 24 days of age from seizures and/or malnutrition.
 
Interactions
Inpp4a interacts with 334 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process dephosphorylation, phosphatidylinositol-3-phosphate biosynthetic process, ...
Function hydrolase activity, phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (188)    Tissues (152)    Images (28)
Theiler Stages: 22, 23, 26, 28
Assay TypeResults
RNA in situ 184
RT-PCR 4
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(6) cDNA(8) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000033181 (Evidence)
Ensembl Gene ModelENSMUSG00000026113 (Evidence)
Entrez Gene269180 (Evidence)
DFCITC1585735, TC1648546, TC1664222
DoTSDT.101224976, DT.489135, DT.91333777, DT.99539299
NIA Mouse Gene IndexU042153, U209086
EC3.1.3.66
Consensus CDS ProjectCCDS35539.1, CCDS35540.1, CCDS69879.1
International Mouse Knockout Project StatusInpp4a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033181 VEGA Gene Model | MGI Sequence Detail 110872 C57BL/6J ±  kb
transcript OTTMUST00000083030 VEGA | MGI Sequence Detail 2934 Not Applicable 
polypeptide OTTMUSP00000044558 VEGA | MGI Sequence Detail 977 Not Applicable 

For the selected sequences
All sequences(107) RefSeq(38) UniProt(11)
Polymorphisms SNPs within 2kb(949 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
Protein Ontology PR:000009045 type I inositol 3,4-bisphosphate 4-phosphatase
References (Earliest) J:66416 Vyas P, et al., Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13696-701
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(38)
Other
accession IDs
MGI:2138728

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory