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Inpp4a
Gene Detail
Symbol

Name
ID
Inpp4a
inositol polyphosphate-4-phosphatase, type I
MGI:1931123
Synonyms
107kDa
Feature Type
protein coding gene
Genetic Map
Chromosome 1
15.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:37299865-37410736 bp, + strand
From VEGA annotation of GRCm38

  110872 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2871  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: INPP4A
Protein SuperFamily: inositol-3,4-bisphosphate 4-phosphatase type I/II
Gene Tree: Inpp4a

Human
homologs
INPP4A, inositol polyphosphate-4-phosphatase, type I, 107kDa
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3631
neXtProt AC: NX_Q96PE3

Human Synonyms: INPP4, TVAS1

Human Chr (Location): 2q11.2; chr2:98444858-98594067 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a spontaneous mutation exhibit small size, ataxia, loss of cerebellar and hippocampal CA1 neurons, and death by 24 days of age from seizures and/or malnutrition.
 
Interactions
Inpp4a interacts with 333 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (188)    Tissues (152)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 184
RT-PCR 4
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase inpp4a    NEW 
Molecular
reagents
All nucleic(16) Genomic(6) cDNA(8) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000033181 (Evidence)
Ensembl Gene Model ENSMUSG00000026113 (Evidence)
Entrez Gene 269180 (Evidence)
DFCI TC1664222, TC1585735, TC1648546
DoTS DT.99539299, DT.91333777, DT.489135, DT.101224976
NIA Mouse Gene Index U042153, U209086
EC 3.1.3.66
Consensus CDS Project CCDS35539.1, CCDS35540.1, CCDS69879.1
International Mouse Phenotyping Consortium Status Inpp4a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033181 VEGA Gene Model | MGI Sequence Detail 110872 C57BL/6J ±  kb
transcript OTTMUST00000083030 VEGA | MGI Sequence Detail 2934 Not Applicable 
polypeptide OTTMUSP00000044558 VEGA | MGI Sequence Detail 977 Not Applicable 

For the selected sequences
All sequences(116) RefSeq(38) UniProt(12)
Polymorphisms
SNPs within 2kb(949 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
Protein Ontology PR:000009045 type I inositol 3,4-bisphosphate 4-phosphatase
References
(Earliest) J:66416 Vyas P, et al., Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13696-701
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)
Other
accession IDs
MGI:2138728

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory