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Inpp4a Gene Detail
Summary
  • Symbol
    Inpp4a
  • Name
    inositol polyphosphate-4-phosphatase, type I
  • Synonyms
    107kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931123
    NCBI Gene: 269180
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:37338946-37449817 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 15.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    942 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931123
protein coding gene Chr1:37338908-37449821 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015936
protein coding gene Chr1:35910507-36023572 (+)
A/J MGP_AJ_G0015920
protein coding gene Chr1:34926316-35037526 (+)
AKR/J MGP_AKRJ_G0015875
protein coding gene Chr1:35413888-35526676 (+)
BALB/cJ MGP_BALBcJ_G0015874
protein coding gene Chr1:34599276-34710431 (+)
C3H/HeJ MGP_C3HHeJ_G0015707
protein coding gene Chr1:35640144-35750780 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016327
protein coding gene Chr1:37498132-37612163 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014049
protein coding gene Chr1:31947360-32057027 (+)
CAST/EiJ MGP_CASTEiJ_G0015288
protein coding gene Chr1:35494884-35609798 (+)
CBA/J MGP_CBAJ_G0015679
protein coding gene Chr1:38512151-38625651 (+)
DBA/2J MGP_DBA2J_G0015780
protein coding gene Chr1:34251432-34361854 (+)
FVB/NJ MGP_FVBNJ_G0015782
protein coding gene Chr1:33775583-33895423 (+)
LP/J MGP_LPJ_G0015850
protein coding gene Chr1:36260753-36373413 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015802
protein coding gene Chr1:40713681-40827194 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016374
protein coding gene Chr1:35473294-35586288 (+)
PWK/PhJ MGP_PWKPhJ_G0015071
protein coding gene Chr1:34012919-34125355 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014853
protein coding gene Chr1:35403367-35522941 (+)
WSB/EiJ MGP_WSBEiJ_G0015350
protein coding gene Chr1:35423849-35540082 (+)



Homology
more
  • Human Ortholog
    INPP4A, inositol polyphosphate-4-phosphatase type I A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INPP4A, inositol polyphosphate-4-phosphatase type I A
  • Synonyms
    INPP4, TVAS1
  • Links
    NCBI Gene ID: 3631
    neXtProt AC: NX_Q96PE3
    UniProt: Q96PE3

  • Chr Location
    2q11.2; chr2:98444587-98594392 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a spontaneous mutation exhibit small size, ataxia, loss of cerebellar and hippocampal CA1 neurons, and death by 24 days of age from seizures and/or malnutrition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026113 Ensembl Gene Model | MGI Sequence Detail 110872 C57BL/6J ±  kb
    transcript ENSMUST00000137266 Ensembl | MGI Sequence Detail 2934 Not Applicable  
    polypeptide ENSMUSP00000121803 Ensembl | MGI Sequence Detail 977 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 6
      cDNA 9
      Primer pair 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2138728
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:66416 Vyas P, et al., Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13696-701
    • Latest
      J:339153 Tran DM, et al., Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity. Dis Model Mech. 2023 Jul 1;16(7)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory