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Noc2l Gene Detail
Summary
  • Symbol
    Noc2l
  • Name
    NOC2 like nucleolar associated transcriptional repressor
  • Synonyms
    NIR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931051
    NCBI Gene: 57741
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:156320376-156332073 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, Syntenic
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    208 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931051
 protein coding gene Chr4:156319112-156332073 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029253
 protein coding gene Chr4:160609056-160620113 (+)
A/J MGP_AJ_G0029218
 protein coding gene Chr4:153842005-153854240 (+)
AKR/J MGP_AKRJ_G0029166
 protein coding gene Chr4:158034291-158047449 (+)
BALB/cJ MGP_BALBcJ_G0029234
 protein coding gene Chr4:154318744-154330502 (+)
C3H/HeJ MGP_C3HHeJ_G0028955
 protein coding gene Chr4:158610347-158624503 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029683
 protein coding gene Chr4:166311526-166322616 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026926
 protein coding gene Chr4:146119018-146131020 (+)
CAST/EiJ MGP_CASTEiJ_G0028367
 protein coding gene Chr4:156031655-156040419 (+)
CBA/J MGP_CBAJ_G0028917
 protein coding gene Chr4:171373164-171388212 (+)
DBA/2J MGP_DBA2J_G0029066
 protein coding gene Chr4:153862207-153874072 (+)
FVB/NJ MGP_FVBNJ_G0029029
 protein coding gene Chr4:153112661-153124145 (+)
LP/J MGP_LPJ_G0029156
 protein coding gene Chr4:160570246-160583097 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029056
 protein coding gene Chr4:174133140-174147161 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029715
 protein coding gene Chr4:158666021-158677781 (+)
PWK/PhJ MGP_PWKPhJ_G0028087
 protein coding gene Chr4:150005142-150016364 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027921
 protein coding gene Chr4:152916128-152926947 (+)
WSB/EiJ MGP_WSBEiJ_G0028447
 protein coding gene Chr4:158848324-158861358 (+)



Homology
more
  • Human Ortholog
    NOC2L, NOC2 like nucleolar associated transcriptional repressor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOC2L, NOC2 like nucleolar associated transcriptional repressor
  • Synonyms
    NET15, NET7, NIR, PPP1R112
  • Links
    NCBI Gene ID: 26155
    neXtProt AC: NX_Q9Y3T9
    UniProt: Q9Y3T9

  • Chr Location
    1p36.33; chr1:944203-959309 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice lacking expression of this gene display embryonic lethality prior to the tooth bud stage. Mice with an immune cell deletion display impaired T and B cell differentiation with a cell cycle defect.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    35
  • cDNA Data
    9
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000095567 Ensembl Gene Model | MGI Sequence Detail 11698 C57BL/6J ±  kb
    transcript ENSMUST00000179543 Ensembl | MGI Sequence Detail 2785 Not Applicable  
    polypeptide ENSMUSP00000137253 Ensembl | MGI Sequence Detail 750 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2140150, MGI:3528176
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 5
    • Earliest
      J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
    • Latest
      J:260456 Duteil D, et al., The histone acetyltransferase inhibitor Nir regulates epidermis development. Development. 2018 Mar 21;145(6):dev158543
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory