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Nelfb Gene Detail
Summary
  • Symbol
    Nelfb
  • Name
    negative elongation factor complex member B
  • Synonyms
    A730008L03Rik, Cobra1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931035
    NCBI Gene: 58202
  • Gene Overview
    MyGene.info: NELFB
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25199712-25211489 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 17.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931035
protein coding gene Chr2:25199712-25211489 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025423
protein coding gene Chr2:23063005-23074783 (-)
A/J MGP_AJ_G0025400
protein coding gene Chr2:22164555-22176334 (-)
AKR/J MGP_AKRJ_G0025370
protein coding gene Chr2:22919094-22930875 (-)
BALB/cJ MGP_BALBcJ_G0025396
protein coding gene Chr2:22287276-22299075 (-)
C3H/HeJ MGP_C3HHeJ_G0025157
protein coding gene Chr2:22848298-22860041 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025840
protein coding gene Chr2:23796856-23808600 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023251
protein coding gene Chr2:21097653-21107917 (-)
CAST/EiJ MGP_CASTEiJ_G0024620
protein coding gene Chr2:22731943-22743710 (-)
CBA/J MGP_CBAJ_G0025135
protein coding gene Chr2:24632751-24644528 (-)
DBA/2J MGP_DBA2J_G0025268
protein coding gene Chr2:22020849-22032669 (-)
FVB/NJ MGP_FVBNJ_G0025230
protein coding gene Chr2:21760604-21772278 (-)
LP/J MGP_LPJ_G0025354
protein coding gene Chr2:23009891-23021668 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025261
protein coding gene Chr2:24837678-24849425 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025899
protein coding gene Chr2:22865313-22877118 (-)
PWK/PhJ MGP_PWKPhJ_G0024368
protein coding gene Chr2:21832094-21843811 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024168
protein coding gene Chr2:23015805-23032843 (-)
WSB/EiJ MGP_WSBEiJ_G0024689
protein coding gene Chr2:22936815-22949613 (-)



Homology
more
  • Human Ortholog
    NELFB, negative elongation factor complex member B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NELFB, negative elongation factor complex member B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COBRA1, NELF-B
  • Links
    NCBI Gene ID: 25920
    neXtProt AC: NX_Q8WX92
    UniProt: Q8WX92

  • Chr Location
    9q34.3; chr9:137255300-137273548 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 121600
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NELFB
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    2 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele fail to develop inner cell masses and die between E5 and E13.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 58202 NCBI Gene Model | MGI Sequence Detail 11778 C57BL/6J ±  kb
    transcript NM_001310157 RefSeq | MGI Sequence Detail 2882 C57BL/6  
    polypeptide Q8C4Y3 UniProt | EBI | MGI Sequence Detail 580 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR010405 Cofactor of BRCA1
    Molecular
    Reagents
    less
    • All nucleic 169
      cDNA 168
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2139041
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:262752 Chiang HC, et al., Gene-Specific Genetic Complementation between Brca1 and Cobra1 During Mouse Mammary Gland Development. Sci Rep. 2018 Feb 9;8(1):2731

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory