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Nelfb
Gene Detail
Symbol

Name
ID
Nelfb
negative elongation factor complex member B
MGI:1931035
Synonyms
A730008L03Rik, Cobra1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
17.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:25199712-25211489 bp, - strand
From VEGA annotation of GRCm38

  11778 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121600  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NELFB
Gene Tree: Nelfb

Human
homologs
NELFB, negative elongation factor complex member B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 25920
neXtProt AC: NX_Q8WX92

Human Synonyms: COBRA1, NELF-B

Human Chr (Location): 9q34; chr9:137255307-137273548 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele fail to develop inner cell masses and die between E5 and E13.5.
 
Phenotype Images(2)
Interactions
Nelfb interacts with 137 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (7)    Tissues (3)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 3
RT-PCR 4
cDNA source data(166)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nelfb    NEW 
Molecular
reagents
All nucleic(168) cDNA(167) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000011781 (Evidence)
Ensembl Gene Model ENSMUSG00000013465 (Evidence)
Entrez Gene 58202 (Evidence)
UniGene 116418
DFCI TC1572010, TC1587446
DoTS DT.101386211, DT.101386213, DT.110684001, DT.111160473, DT.490358
NIA Mouse Gene Index U022376
Consensus CDS Project CCDS15751.2
International Mouse Phenotyping Consortium Status Nelfb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011781 VEGA Gene Model | MGI Sequence Detail 11778 C57BL/6J ±  kb
transcript OTTMUST00000027648 VEGA | MGI Sequence Detail 2637 Not Applicable 
polypeptide OTTMUSP00000012561 VEGA | MGI Sequence Detail 580 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(5) UniProt(4)
Polymorphisms
SNPs within 2kb(56 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010405 Cofactor of BRCA1
Protein Ontology PR:000005682 negative elongation factor B
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:211827 Pan H, et al., Negative elongation factor controls energy homeostasis in cardiomyocytes. Cell Rep. 2014 Apr 10;7(1):79-85
All references(35)
Other
accession IDs
MGI:2139041

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory