Acp6 MGI Mouse Gene Detail - MGI:1931010 - acid phosphatase 6, lysophosphatidic

Symbol

Acp6
Name

acid phosphatase 6, lysophosphatidic
Synonyms

5730559A09Rik, ACPL1, mPACPL1

Feature Type

protein coding gene
IDs

MGI:1931010
NCBI Gene: 66659
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:97066070-97083892 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 42.04 cM
Mapping Data

2 experiments

SNPs within 2kb

480 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1931010	protein coding gene	Chr3:97066070-97084615 (+)
129S1/SvImJ	ENSMUSG00200041521	protein coding gene	Chr3:93692778-93710693 (+)
A/J	ENSMUSG00195047528	protein coding gene	Chr3:94095736-94113533 (+)
AKR/J	ENSMUSG00220038876	protein coding gene	Chr3:92447825-92465622 (+)
BALB/cJ	ENSMUSG00180031288	protein coding gene	Chr3:94042392-94060190 (+)
C3H/HeJ	ENSMUSG00175027547	protein coding gene	Chr3:93654144-93671941 (+)
C57BL/6NJ	ENSMUSG00215017931	protein coding gene	Chr3:94424035-94441830 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025397	protein coding gene	Chr3:91180641-91199258 (+)
CAST/EiJ	ENSTCUG00005018667	protein coding gene	Chr3:94245010-94262899 (+)
CBA/J	ENSMUSG00210050571	protein coding gene	Chr3:94207117-94224914 (+)
DBA/2J	ENSMUSG00185043058	protein coding gene	Chr3:94664394-94682191 (+)
FVB/NJ	ENSMUSG00205013422	protein coding gene	Chr3:93326746-93344613 (+)
JF1/MsJ	ENSUMUG00000029215	protein coding gene	Chr3:93511444-93529151 (+)
LP/J	ENSMUSG00230044876	protein coding gene	Chr3:96624553-96642471 (+)
NOD/ShiLtJ	ENSMUSG00190045845	protein coding gene	Chr3:94758322-94776177 (+)
NZO/HlLtJ	ENSMUSG00225012257	protein coding gene	Chr3:99009530-99027416 (+)
PWK/PhJ	ENSLUMG00010026693	protein coding gene	Chr3:93507029-93524780 (+)
SPRET/EiJ	ENSMSPG00010037220	protein coding gene	Chr3:93795455-93813474 (+)
WSB/EiJ	ENSIUOG00005030275	protein coding gene	Chr3:94160930-94178845 (+)

Human Ortholog

ACP6, acid phosphatase 6, lysophosphatidic

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACP6, acid phosphatase 6, lysophosphatidic
Synonyms

ACPL1, LPAP, PACPL1
Links

HGNC:29609

NCBI Gene ID: 51205

UniProt: Q9NPH0
Chr Location

1q21.2; chr1:147629652-147670531 (-) GRCh38

MGI Vertebrate Homology

Acp6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACP6
Gene Tree

Acp6

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

14
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Acp6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available

Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested.

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All GO Annotations

21
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

96
cDNA Data

13
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acp6

ZFIN acp6

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All Sequences

54
RefSeq

4
UniProt

1
CCDS

CCDS17653.1

Ensembl

ENSMUSG00000028093 (Evidence)
NCBI Gene

66659

			Length	Strain/Species	Flank
genomic	66659	NCBI Gene Model \| MGI Sequence Detail	17823	C57BL/6J	± kb
transcript	NM_019800	RefSeq \| MGI Sequence Detail	1756	C57BL/6
polypeptide	Q8BP40	UniProt \| EBI \| MGI Sequence Detail	418	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003648 lysophosphatidic acid phosphatase type 6

(term hierarchy)
EC

3.1.3.106
InterPro Domains

IPR050645 Histidine Acid Phosphatase

IPR033379 Histidine acid phosphatase active site

IPR029033 Histidine phosphatase superfamily

IPR000560 Histidine phosphatase superfamily, clade-2
GlyGen

Q8BP40 1 site, 1 O-linked glycan (1 site)

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 5

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MGI:1913909, MGI:2139897

Summaries

All 56

Developmental Gene Expression 2

Diseases 1

Gene Ontology 12

Phenotypes 20
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acp6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30784	Chr3:97066083-97066136 (+)	40 bp
Tssr30785	Chr3:97066139-97066161 (+)	80 bp
Tssr30786	Chr3:97066168-97066186 (+)	107 bp
Tssr30787	Chr3:97066326-97066353 (+)	270 bp
Tssr30788	Chr3:97066363-97066380 (+)	302 bp
Tssr30789	Chr3:97066395-97066417 (+)	336 bp
Tssr30790	Chr3:97070305-97070318 (+)	4,242 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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