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Acp6 Gene Detail
Summary
  • Symbol
    Acp6
  • Name
    acid phosphatase 6, lysophosphatidic
  • Synonyms
    5730559A09Rik, ACPL1, mPACPL1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931010
    NCBI Gene: 66659
  • Gene Overview
    MyGene.info: ACP6
Location & Maps
more
  • Sequence Map
    Chr3:97158777-97177299 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18523 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 42.04 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ACP6, acid phosphatase 6, lysophosphatidic
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACP6, acid phosphatase 6, lysophosphatidic
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACPL1, LPAP, PACPL1
  • Links
    NCBI Gene ID: 51205
    neXtProt AC: NX_Q9NPH0

  • Chr Location
    1q21; chr1:147629286-147670512 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 41128
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ACP6
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
  • All Mutations and Alleles
    35
  • Chemically induced (other)
    1
  • Gene trapped
    30
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Acp6
  • Incidental Mutations
Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022388 VEGA Gene Model | MGI Sequence Detail 18523 C57BL/6J ±  kb
transcript OTTMUST00000053489 VEGA | MGI Sequence Detail 1754 Not Applicable  
polypeptide OTTMUSP00000025435 VEGA | MGI Sequence Detail 418 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    86 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000003648 lysophosphatidic acid phosphatase type 6
  • EC
  • InterPro Domains
    IPR033379 Histidine acid phosphatase active site
    IPR029033 Histidine phosphatase superfamily
    IPR000560 Histidine phosphatase superfamily, clade-2
Molecular
Reagents
less
  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1913909, MGI:2139897
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory