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Edaradd Gene Detail
Summary
  • Symbol
    Edaradd
  • Name
    EDAR (ectodysplasin-A receptor)-associated death domain
  • Synonyms
    1810032E07Rik, 5830469M23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931001
    NCBI Gene: 171211
  • Gene Overview
    MyGene.info: EDARADD
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:12472632-12520438 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 4.77 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    327 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931001
protein coding gene Chr13:12471209-12520704 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020232
protein coding gene Chr13:9235904-9286705 (-)
A/J MGP_AJ_G0020188
protein coding gene Chr13:9057543-9108086 (-)
AKR/J MGP_AKRJ_G0020163
protein coding gene Chr13:9260528-9311186 (-)
BALB/cJ MGP_BALBcJ_G0020171
protein coding gene Chr13:9042520-9092737 (-)
C3H/HeJ MGP_C3HHeJ_G0019975
protein coding gene Chr13:9389613-9446276 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020618
protein coding gene Chr13:9655231-9707246 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018225
protein coding gene Chr13:8888505-8940599 (-)
CAST/EiJ MGP_CASTEiJ_G0019513
protein coding gene Chr13:9100936-9154094 (-)
CBA/J MGP_CBAJ_G0019942
protein coding gene Chr13:9913217-9967165 (-)
DBA/2J MGP_DBA2J_G0020059
protein coding gene Chr13:8877193-8927479 (-)
FVB/NJ MGP_FVBNJ_G0020044
protein coding gene Chr13:8695407-8745204 (-)
LP/J MGP_LPJ_G0020133
protein coding gene Chr13:9335267-9386461 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020080
protein coding gene Chr13:10195831-10248726 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020646
protein coding gene Chr13:9158817-9208790 (-)
PWK/PhJ MGP_PWKPhJ_G0019276
protein coding gene Chr13:8916199-8968850 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019083
protein coding gene Chr13:9142291-9198721 (-)
WSB/EiJ MGP_WSBEiJ_G0019573
protein coding gene Chr13:9124461-9179916 (-)



Homology
more
  • Human Ortholog
    EDARADD, EDAR associated death domain
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EDARADD, EDAR associated death domain
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ECTD11A, ECTD11B, ED3, EDA3
  • Links
    NCBI Gene ID: 128178
    neXtProt AC: NX_Q8WWZ3
    UniProt: Q8WWZ3

  • Chr Location
    1q42.3-q43; chr1:236394380-236484708 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human EDARADD associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    63 phenotypes from 5 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Spontaneous mutations may lead to a kinked tail, reduced fertility, abnormal respiration and sparse hair. Chemically-induced mutants may show developmental defects in teeth, hair and ectoderm-derived glands, reduced viability and fertility, respiratory disorders, and lipid, myelin and brain defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000095105 Ensembl Gene Model | MGI Sequence Detail 47807 C57BL/6J ±  kb
    transcript ENSMUST00000179308 Ensembl | MGI Sequence Detail 6668 Not Applicable  
    polypeptide ENSMUSP00000136158 Ensembl | MGI Sequence Detail 208 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR000488 Death domain
      IPR011029 Death-like domain superfamily
      IPR039200 Ectodysplasin-A receptor-associated adapter protein
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 22

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2121, MGI:1923329, MGI:1923604, MGI:88488
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 32
    • Earliest
      J:13040 Falconer DS, et al., The genetics and development of "crinkled", a new mutant in the house mouse. J Genet. 1951;50:324-344
    • Latest
      J:237866 Azar A, et al., Ectodysplasin signalling deficiency in mouse models of hypohidrotic ectodermal dysplasia leads to middle ear and nasal pathology. Hum Mol Genet. 2016 Aug 15;25(16):3564-3577

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory