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Edaradd
Gene Detail
Symbol

Name
ID
Edaradd
EDAR (ectodysplasin-A receptor)-associated death domain
MGI:1931001
Synonyms
1810032E07Rik, 5830469M23Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 13
4.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr13:12471209-12520450 bp, - strand
From Ensembl annotation of GRCm38

  49242 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EDARADD
Gene Tree: Edaradd

Human
homologs
EDARADD, EDAR-associated death domain
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 128178
neXtProt AC: NX_Q8WWZ3

Human Synonyms: ECTD11A, ECTD11B, ED3, EDA3

Human Chr (Location): 1q42.3; chr1:236394380-236484708 (+)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human EDARADD

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(2) Chemically induced (other)(1) Gene trapped(2) Spontaneous(2) Targeted(1)
Incidental mutations (data from APF )
 
Spontaneous mutations may lead to a kinked tail, reduced fertility, abnormal respiration and sparse hair. Chemically-induced mutants may show developmental defects in teeth, hair and ectoderm-derived glands, reduced viability and fertility, respiratory disorders, and lipid, myelin and brain defects.
 
Phenotype Images(2)
Interactions
Edaradd interacts with 454 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell differentiation, hair follicle development, ...
Component cytoplasm
Function death receptor binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (118)    Tissues (57)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 116
Northern blot 2
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA EDARADD    NEW 
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(21)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000095105 (Evidence)
Entrez Gene 171211 (Evidence)
UniGene 159671
DFCI TC1612115, TC1695873, TC1596786, TC1584609
DoTS DT.97357259, DT.87033119, DT.101721996
NIA Mouse Gene Index U034515, U324948
Consensus CDS Project CCDS36593.1
International Mouse Phenotyping Consortium Status Edaradd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000095105 Ensembl Gene Model | MGI Sequence Detail 49242 C57BL/6J ±  kb
transcript ENSMUST00000179308 Ensembl | MGI Sequence Detail 8103 Not Applicable 
polypeptide ENSMUSP00000136158 Ensembl | MGI Sequence Detail 208 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(5) UniProt(4)
Polymorphisms
SNPs within 2kb(335 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
Protein Ontology PR:000006889 ectodysplasin-A receptor-associated adapter protein
References
(Earliest) J:64273 Falconer DS, cr - crinkled. Mouse News Lett. 1949;1S:4
(Latest) J:171050 Thiagarajan RD, et al., Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One. 2011;6(2):e17286
All references(68)
Other
accession IDs
MGD-MRK-2121, MGI:1923329, MGI:1923604, MGI:88488

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory