About   Help   FAQ
Edaradd
Gene Detail
 Symbol
Name
ID
Edaradd
EDAR (ectodysplasin-A receptor)-associated death domain
MGI:1931001
Synonyms 1810032E07Rik, 5830469M23Rik
Feature Type protein coding gene
Genetic Map
Chromosome 13
4.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)
Sequence Map
Chr13:12471209-12520450 bp, - strand
From NCBI annotation of GRCm38

  49242 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Edaradd

Human
homologs
Human Homolog EDARADD, EDAR-associated death domain
NCBI Gene ID 128178
neXtProt AC  NX_Q8WWZ3
Human Synonyms  ECTD11A, ECTD11B, ED3, EDA3
Human Chr (Location)  1q42.3; chr1:236394380-236484708 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human EDARADD
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(2) Chemically induced (other)(1) Gene trapped(2) Spontaneous(2) Targeted(1)
Incidental mutations (data from APF )
 
Spontaneous mutations may lead to a kinked tail, reduced fertility, abnormal respiration and sparse hair. Chemically-induced mutants may show developmental defects in teeth, hair and ectoderm-derived glands, reduced viability and fertility, respiratory disorders, and lipid, myelin and brain defects.
 
Phenotype Images(2)
Interactions
Edaradd interacts with 454 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell differentiation, hair follicle development, ...
Component cytoplasm
Function death receptor binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (118)    Tissues (57)    Images (26)
Theiler Stages: 20, 22, 23, 26
Assay TypeResults
RNA in situ 116
Northern blot 2
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(21)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000095105 (Evidence)
Entrez Gene171211 (Evidence)
UniGene159671
DFCITC1584609, TC1596786, TC1612115, TC1695873
DoTSDT.101721996, DT.87033119, DT.97357259
NIA Mouse Gene IndexU034515, U324948
Consensus CDS ProjectCCDS36593.1
International Mouse Knockout Project StatusEdaradd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 171211 NCBI Gene Model | MGI Sequence Detail 49242 C57BL/6J ±  kb
transcript NM_133643 RefSeq | MGI Sequence Detail 8103 C57BL/6 
polypeptide Q8VHX2 UniProt | EBI | MGI Sequence Detail 208 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(5) UniProt(4)
Polymorphisms SNPs within 2kb(335 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
Protein Ontology PR:000006889 ectodysplasin-A receptor-associated adapter protein
Graphical View of Protein Domain Structure
References (Earliest) J:64273 Falconer DS, cr - crinkled. Mouse News Lett. 1949;1S:4
(Latest) J:171050 Thiagarajan RD, et al., Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One. 2011;6(2):e17286
All references(68)
Other
accession IDs
MGD-MRK-2121, MGI:1923329, MGI:1923604, MGI:88488

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory