Edaradd
Gene Detail

Symbol Name ID

Edaradd EDAR (ectodysplasin-A receptor)-associated death domain MGI:1931001

Synonyms

1810032E07Rik, 5830469M23Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 13

4.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(20)

Sequence Map

Chr13:12471209-12520450 bp, - strand From NCBI annotation of GRCm38   49242 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:15430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Edaradd

Human homologs

Human Homolog		EDARADD, EDAR-associated death domain
NCBI Gene ID		128178
neXtProt AC		NX_Q8WWZ3
Human Synonyms		ECTD11A, ECTD11B, ED3, EDA3
Human Chr (Location)		1q42.3; chr1:236557680-236648008 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human EDARADD

Alleles and phenotypes

All alleles(8) : Targeted(1) Gene trapped(2) Spontaneous(2) Chemically induced(3)
 

Spontaneous mutations may lead to a kinked tail, reduced fertility, abnormal respiration and sparse hair. Chemically-induced mutants may show developmental defects in teeth, hair and ectoderm-derived glands, reduced viability and fertility, respiratory disorders, and lipid, myelin and brain defects.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	cell differentiation, hair follicle development, ...
Component	cytoplasm
Function	death receptor binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (118)    Tissues (57)    Images (26)
Theiler Stages: 20, 22, 23, 26

Assay Type	Results
RNA in situ	116
Northern blot	2

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(1) cDNA(13)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000095105 (Evidence)
Entrez Gene	171211 (Evidence)
DFCI	TC1584609, TC1596786, TC1612115, TC1695873
DoTS	DT.101721996, DT.87033119, DT.97357259
NIA Mouse Gene Index	U034515, U324948
Consensus CDS Project	CCDS36593.1
International Mouse Knockout Project Status	Edaradd

Sequences

Length	Strain/Species
genomic	171211	NCBI Gene Model | MGI Sequence Detail	49242	C57BL/6J
transcript	NM_133643	RefSeq | MGI Sequence Detail	8103	C57BL/6
polypeptide	Q8VHX2	UniProt | EBI | MGI Sequence Detail	208	Not Applicable

All sequences(31) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(230 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000488	Death
InterPro	IPR011029	DEATH-like
Protein Ontology	PR:000006889	ectodysplasin-A receptor-associated adapter protein

Graphical View of Protein Domain Structure

References

(Earliest) J:64273 Falconer DS, cr - crinkled. Mouse News Lett. 1949;1S:4
(Latest) J:171050 Thiagarajan RD, et al., Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One. 2011;6(2):e17286
All references(67)

Other accession IDs

MGD-MRK-2121, MGI:1923329, MGI:1923604, MGI:88488