About   Help   FAQ
Gpr180 Gene Detail
Summary
  • Symbol
    Gpr180
  • Name
    G protein-coupled receptor 180
  • Synonyms
    E130016I23Rik, ITR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930949
    NCBI Gene: 58245
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:118137158-118163261 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 61.78 cM, cytoband E4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    268 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930949
protein coding gene Chr14:118137111-118164232 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021648
protein coding gene Chr14:115702070-115730039 (+)
A/J MGP_AJ_G0021607
protein coding gene Chr14:111295735-111323371 (+)
AKR/J MGP_AKRJ_G0021583
protein coding gene Chr14:114911578-114938835 (+)
BALB/cJ MGP_BALBcJ_G0021613
protein coding gene Chr14:111839864-111865622 (+)
C3H/HeJ MGP_C3HHeJ_G0021391
protein coding gene Chr14:114788824-114814530 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022053
protein coding gene Chr14:120207128-120234577 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019592
protein coding gene Chr14:107367992-107394159 (+)
CAST/EiJ MGP_CASTEiJ_G0020907
protein coding gene Chr14:112619217-112647875 (+)
CBA/J MGP_CBAJ_G0021359
protein coding gene Chr14:124809900-124840795 (+)
DBA/2J MGP_DBA2J_G0021482
protein coding gene Chr14:111220817-111246673 (+)
FVB/NJ MGP_FVBNJ_G0021460
protein coding gene Chr14:109554034-109580713 (+)
LP/J MGP_LPJ_G0021550
protein coding gene Chr14:116741453-116769870 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021487
protein coding gene Chr14:129897536-129929468 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022076
protein coding gene Chr14:114371541-114400876 (+)
PWK/PhJ MGP_PWKPhJ_G0020651
protein coding gene Chr14:108206873-108232518 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020489
protein coding gene Chr14:110623940-110650943 (+)
WSB/EiJ MGP_WSBEiJ_G0020962
protein coding gene Chr14:115170065-115200272 (+)



Homology
more
  • Human Ortholog
    GPR180, G protein-coupled receptor 180
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GPR180, G protein-coupled receptor 180
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ITR
  • Links
    NCBI Gene ID: 160897
    neXtProt AC: NX_Q86V85
    UniProt: Q86V85

  • Chr Location
    13q32.1; chr13:94601850-94634645 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32506
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GPR180
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are resistant to cuff-induced intimal thickening of the femoral artery.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022131 Ensembl Gene Model | MGI Sequence Detail 26104 C57BL/6J ±  kb
    transcript ENSMUST00000022728 Ensembl | MGI Sequence Detail 1875 Not Applicable  
    polypeptide ENSMUSP00000022728 Ensembl | MGI Sequence Detail 441 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 30

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:67314 Roix J, et al., Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14. Genetics. 2001 Feb;157(2):803-15
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory