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Rrad Gene Detail
Summary
  • Symbol
    Rrad
  • Name
    Ras-related associated with diabetes
  • Synonyms
    Rad, REM3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930943
    NCBI Gene: 56437
  • Gene Overview
    MyGene.info: RRAD
Location & Maps
more
  • Sequence Map
    Chr8:104628066-104631321 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3256 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RRAD, RRAD, Ras related glycolysis inhibitor and calcium channel regulator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RRAD, RRAD, Ras related glycolysis inhibitor and calcium channel regulator
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RAD, RAD1, REM3
  • Links
    NCBI Gene ID: 6236
    neXtProt AC: NX_P55042

  • Chr Location
    16q22; chr16:66921679-66925536 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are more susceptible to pressure overload-induced cardiac hypertrophy and display weaker left ventricular contractility than control mice at higher doses of dobutamine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031880 Ensembl Gene Model | MGI Sequence Detail 3256 C57BL/6J ±  kb
transcript ENSMUST00000034351 Ensembl | MGI Sequence Detail 1575 Not Applicable  
polypeptide ENSMUSP00000034351 Ensembl | MGI Sequence Detail 307 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000014296 GTP-binding protein RAD
  • InterPro Domains
    IPR028869 GTP-binding protein Rad
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase superfamily
    IPR017358 Small GTPase superfamily, GEM/REM/Rad
    IPR020849 Small GTPase superfamily, Ras type
Molecular
Reagents
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  • All nucleic 21
    cDNA 21

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory