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Rrad Gene Detail
Summary
  • Symbol
    Rrad
  • Name
    Ras-related associated with diabetes
  • Synonyms
    Rad, REM3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930943
    NCBI Gene: 56437
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:105354702-105357921 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930943
 protein coding gene Chr8:105354702-105357959 (-)
129S1/SvImJ ENSMUSG00200014535
 protein coding gene Chr8:99652950-99656207 (-)
A/J ENSMUSG00195003932
 protein coding gene Chr8:99936458-99939715 (-)
AKR/J ENSMUSG00220010812
 protein coding gene Chr8:100103571-100106828 (-)
BALB/cJ ENSMUSG00180003920
 protein coding gene Chr8:99961861-99965118 (-)
C3H/HeJ ENSMUSG00175002602
 protein coding gene Chr8:100018623-100021880 (-)
C57BL/6NJ ENSMUSG00215001217
 protein coding gene Chr8:99632932-99636189 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031453
 protein coding gene Chr8:95807902-95811134 (-)
CAST/EiJ ENSTCUG00005022684
 protein coding gene Chr8:99418608-99421872 (-)
CBA/J ENSMUSG00210015003
 protein coding gene Chr8:99947230-99950487 (-)
DBA/2J ENSMUSG00185004945
 protein coding gene Chr8:106055098-106058355 (-)
FVB/NJ ENSMUSG00205010686
 protein coding gene Chr8:98980069-98983326 (-)
JF1/MsJ ENSUMUG00000011950
 protein coding gene Chr8:108388328-108391585 (-)
LP/J ENSMUSG00230008003
 protein coding gene Chr8:109735631-109738888 (-)
NOD/ShiLtJ ENSMUSG00190012031
 protein coding gene Chr8:100085292-100088549 (-)
NZO/HlLtJ ENSMUSG00225020533
 protein coding gene Chr8:113086130-113089387 (-)
PWK/PhJ ENSLUMG00010003865
 protein coding gene Chr8:99902393-99905660 (-)
SPRET/EiJ ENSMSPG00010039967
 protein coding gene Chr8:102020167-102023092 (-)
WSB/EiJ ENSIUOG00005005899
 protein coding gene Chr8:100765322-100768580 (-)



Homology
more
  • Human Ortholog
    RRAD, RRAD, Ras related glycolysis inhibitor and calcium channel regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RRAD, RRAD, Ras related glycolysis inhibitor and calcium channel regulator
  • Synonyms
    RAD, REM3
  • Links
    NCBI Gene ID: 6236
    UniProt: P55042

  • Chr Location
    16q22.1; chr16:66921682-66926308 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RRAD associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are more susceptible to pressure overload-induced cardiac hypertrophy and display weaker left ventricular contractility than control mice at higher doses of dobutamine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    654
  • Tissues
    44
  • cDNA Data
    23
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56437 NCBI Gene Model | MGI Sequence Detail 3220 C57BL/6J ±  kb
    transcript NM_019662 RefSeq | MGI Sequence Detail 1539 C57BL/6  
    polypeptide O88667 UniProt | EBI | MGI Sequence Detail 308 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 23

      Microarray probesets 3
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:19208 Maguire J, et al., Gem: an induced, immediate early protein belonging to the Ras family. Science. 1994 Jul 8;265(5169):241-4
    • Latest
      J:375445 Elmore G, et al., RRAD-reduction reveals efficacy of targeting L-type calcium channel regulation for treatment of heart failure. Cardiovasc Res. 2025 Nov 22;121(14):2204-2221
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory