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Rrad
Gene Detail
Symbol

Name
ID
Rrad
Ras-related associated with diabetes
MGI:1930943
Synonyms
Rad, REM3
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:104628066-104631321 bp, - strand
From Ensembl annotation of GRCm38

  3256 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3071  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: GTP-binding protein, GEM type
Gene Tree: Rrad

Human
homologs
Human Homolog RRAD, ras-related associated with diabetes
NCBI Gene ID 6236
neXtProt AC  NX_P55042
Human Synonyms  RAD, RAD1, REM3
Human Chr (Location)  16q22; chr16:66921679-66925536 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are more susceptible to pressure overload-induced cardiac hypertrophy and display weaker left ventricular contractility than control mice at higher doses of dobutamine.
 
Interactions
Rrad interacts with 51 markers (Mir7-1, Mir20a, Mir30a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process GTP catabolic process, negative regulation of cell growth, ...
Component membrane, plasma membrane
Function calmodulin binding, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (34)    Tissues (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 22
Northern blot 12
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031880 (Evidence)
Entrez Gene56437 (Evidence)
UniGene29467
DFCITC1580108
DoTSDT.489059
NIA Mouse Gene IndexU030160
Consensus CDS ProjectCCDS22584.1
International Mouse Knockout Project StatusRrad
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031880 Ensembl Gene Model | MGI Sequence Detail 3256 C57BL/6J ±  kb
transcript ENSMUST00000034351 Ensembl | MGI Sequence Detail 1575 Not Applicable 
polypeptide ENSMUSP00000034351 Ensembl | MGI Sequence Detail 307 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR017358 Small GTPase superfamily, GEM/REM/Rad
InterPro IPR020849 Small GTPase superfamily, Ras type
Protein Ontology PR:000014296 GTP-binding protein RAD
References
(Earliest) J:66490 Shimizu-Nishikawa K, et al., Identification and characterization of newt rad (ras associated with diabetes), a gene specifically expressed in regenerating limb muscle. Dev Dyn. 2001 Jan;220(1):74-86
(Latest) J:191632 Zhang J, et al., Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor. Cardiovasc Res. 2011 Jul 1;91(1):90-8
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory