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Rrad
Gene Detail
Symbol

Name
ID
Rrad
Ras-related associated with diabetes
MGI:1930943
Synonyms
Rad, REM3
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:104628066-104631321 bp, - strand
From Ensembl annotation of GRCm38

  3256 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3071  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RRAD
Protein SuperFamily: GTP-binding protein, GEM type
Gene Tree: Rrad

Human
homologs
RRAD, ras-related associated with diabetes
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6236
neXtProt AC: NX_P55042

Human Synonyms: RAD, RAD1, REM3

Human Chr (Location): 16q22; chr16:66921679-66925536 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are more susceptible to pressure overload-induced cardiac hypertrophy and display weaker left ventricular contractility than control mice at higher doses of dobutamine.
 
Interactions
Rrad interacts with 51 markers (Mir7-1, Mir20a, Mir30a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process negative regulation of cell growth, signal transduction, ...
Component membrane, plasma membrane
Function calmodulin binding, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (34)    Tissues (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 22
Northern blot 12
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rrad ; ZFIN rrad    NEW 
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000031880 (Evidence)
Entrez Gene 56437 (Evidence)
UniGene 29467
DFCI TC1580108
DoTS DT.489059
NIA Mouse Gene Index U030160
Consensus CDS Project CCDS22584.1
International Mouse Phenotyping Consortium Status Rrad
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031880 Ensembl Gene Model | MGI Sequence Detail 3256 C57BL/6J ±  kb
transcript ENSMUST00000034351 Ensembl | MGI Sequence Detail 1575 Not Applicable 
polypeptide ENSMUSP00000034351 Ensembl | MGI Sequence Detail 307 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR017358 Small GTPase superfamily, GEM/REM/Rad
InterPro IPR020849 Small GTPase superfamily, Ras type
Protein Ontology PR:000014296 GTP-binding protein RAD
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:191632 Zhang J, et al., Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor. Cardiovasc Res. 2011 Jul 1;91(1):90-8
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory