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Tesc Gene Detail
Summary
  • Symbol
    Tesc
  • Name
    tescalcin
  • Synonyms
    1010001A17Rik, 2410011K10Rik, TE-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930803
    NCBI Gene: 57816
Location & Maps
more
  • Sequence Map
    Chr5:118027743-118061878 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34136 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 57.84 cM, cytoband F
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TESC, tescalcin
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TESC, tescalcin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CHP3, TSC
  • Links
    NCBI Gene ID: 54997
    neXtProt AC: NX_Q96BS2

  • Chr Location
    12q24.22; chr12:117038923-117099446 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 75158
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: TESC
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Gene trapped
    16
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Tesc
  • Incidental Mutations
Mice homozygous for deletions in this gene display normal morphology and numbers of megakaryocytes. Platelet numbers are also normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021294 VEGA Gene Model | MGI Sequence Detail 34136 C57BL/6J ±  kb
transcript OTTMUST00000050483 VEGA | MGI Sequence Detail 1031 Not Applicable  
polypeptide OTTMUSP00000023573 VEGA | MGI Sequence Detail 214 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    338 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016240 calcineurin B homologous protein 3
  • InterPro Domains
    IPR018247 EF-Hand 1, calcium-binding site
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
Molecular
Reagents
less
  • All nucleic 30
    cDNA 27
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGI:1922844, MGI:1923519
References
more
  • Summaries
    All 39
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:182299 Ukarapong S, et al., Megakaryocyte development is normal in mice with targeted disruption of Tescalcin. Exp Cell Res. 2012 Mar 10;318(5):662-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory