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Insm2 Gene Detail
Summary
  • Symbol
    Insm2
  • Name
    insulinoma-associated 2
  • Synonyms
    mlt 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930787
    NCBI Gene: 56856
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:55599427-55602086 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 24.05 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930787
protein coding gene Chr12:55598917-55602086 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019751
protein coding gene Chr12:54655131-54658232 (+)
A/J MGP_AJ_G0019710
protein coding gene Chr12:52696276-52699377 (+)
AKR/J MGP_AKRJ_G0019685
protein coding gene Chr12:54356577-54359678 (+)
BALB/cJ MGP_BALBcJ_G0019690
protein coding gene Chr12:53053204-53056305 (+)
C3H/HeJ MGP_C3HHeJ_G0019495
protein coding gene Chr12:54421483-54424581 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020142
protein coding gene Chr12:56291108-56294209 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017762
protein coding gene Chr12:51199065-51202193 (+)
CAST/EiJ MGP_CASTEiJ_G0019047
protein coding gene Chr12:49284598-49287688 (+)
CBA/J MGP_CBAJ_G0019464
protein coding gene Chr12:58281978-58285079 (+)
DBA/2J MGP_DBA2J_G0019580
protein coding gene Chr12:52606479-52609580 (+)
FVB/NJ MGP_FVBNJ_G0019568
protein coding gene Chr12:51903932-51907043 (+)
LP/J MGP_LPJ_G0019652
protein coding gene Chr12:54651361-54654462 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019606
protein coding gene Chr12:59832035-59835134 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020176
protein coding gene Chr12:53804300-53807399 (+)
PWK/PhJ MGP_PWKPhJ_G0018814
protein coding gene Chr12:46958779-46961965 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018607
protein coding gene Chr12:48207333-48210419 (+)
WSB/EiJ MGP_WSBEiJ_G0019098
protein coding gene Chr12:54314134-54317240 (+)



Homology
more
  • Human Ortholog
    INSM2, INSM transcriptional repressor 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    INSM2, INSM transcriptional repressor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IA6, IA-6, mlt1
  • Links
    NCBI Gene ID: 84684
    neXtProt AC: NX_Q96T92
    UniProt: Q96T92

  • Chr Location
    14q13.2; chr14:35534042-35537054 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045440 Ensembl Gene Model | MGI Sequence Detail 2660 C57BL/6J ±  kb
transcript ENSMUST00000051857 Ensembl | MGI Sequence Detail 2660 Not Applicable  
polypeptide ENSMUSP00000061046 Ensembl | MGI Sequence Detail 493 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 26
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:67331 Tateno M, et al., Identification of a novel member of the snail/Gfi-1 repressor family, mlt 1, which is methylated and silenced in liver tumors of SV40 T antigen transgenic mice. Cancer Res. 2001 Feb 1;61(3):1144-53
  • Latest
    J:267715 Wiwatpanit T, et al., Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1. Nature. 2018 Nov;563(7733):691-695

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory